DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itga9

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_038938627.1	Gene:	Itga9 / 685004	RGDID:	1311191	Length:	1036	Species:	Rattus norvegicus

Alignment Length:	1192	Identity:	312/1192 - (26%)
Similarity:	518/1192 - (43%)	Gaps:	250/1192 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNRQPNTTHS-GALWRCP 97
            :|::.:.|:...|.|.|.|||:|..|.      .:.|..||||||...::...:..| ||:::|.
  Rat    31 YNIDAQRPVRFQGPPGSFFGYAVLEHF------HDNTRWVLVGAPKADSKYSTSVKSPGAVFKCR 89

  Fly    98 MTQRFD-DCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQANGSGGKVIVCAHRY- 160
            :....| .|.::.....||...........|  ::|:||||::...|    .:.|:|:.||||:
  Rat    90 VHTNPDRRCTELDMARERNRGESCGKTCRGD--RDDEWMGVSLARQP----KADGRVLACAHRWK 148

  Fly   161 -MYIVRENRYGQGLCYLLTNDLQFE-EVHEPCKGRPVQRQHEDYGLCQAGTSAALLDDDTMVLGS 223
             :|...::....|.|||:.::||.: .:..||.....::..|::|.||||. |....::.:::|:
  Rat   149 NIYYETDHILPHGFCYLIPSNLQAKGRMLIPCYEEYKKKYGEEHGSCQAGI-AGFFTEELVIMGA 212

  Fly   224 PGPYTWRGSIWVTQVGGEYLQRDKTTYY--SDHSDLNSPVDKYSYLGMSVTGGRFFGHMS---YA 283
            ||.:.|.|::.|       |.....||:  :|.:.:|.   :|:|||.:||.|. |.|.|   ..
  Rat   213 PGSFYWAGTLKV-------LNLTDNTYFKLNDDAIMNR---RYTYLGYAVTAGH-FSHPSVTDVV 266

  Fly   284 AGAPRSEGHGQVVIF--DKSTDNPIPVHSILDGEQFGSSFGYELATADINGDHRPDLIVAAPLYF 346
            .|||:.||.|:|.||  |:.:...|.:.. ..|::.||.||..|...|:|.|...||:|.||::.
  Rat   267 GGAPQDEGIGKVYIFRADRRSGTLIKIFQ-ASGKKMGSYFGSSLCAVDLNMDGLSDLLVGAPMFS 330

  Fly   347 TKTEGGAVYVYQNIQDTLPMKYTLKLTG--PLESRFGLALANIGDLNKDNCEDLAVGAPYEGN-- 407
            ...:.|.|.||.| |....::..|.|||  ...:.||.::|::|||:.|...|:|||||.|.:
  Rat   331 EIRDEGQVTVYLN-QGHGVLEEQLTLTGDAAYNAHFGESIASLGDLDDDGFPDVAVGAPMEDDFA 394

  Fly   408 GVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPI-RTFGISISGNTDLDDNSYPDVVIGAFNS 471
            |.||||.|.:||:..:.:.|:...::       .|| :.||.||||..|:|.|.||||.:|||.|
  Rat   395 GTVYIYHGDAQGIVPQYSMKLSGRKI-------NPILQMFGQSISGGIDMDGNGYPDVTVGAFLS 452

  Fly   472 SAAVILLARPIISIQTSVQRKELHNMDPNTPGCLD--DPAS--NLT-CFTFRACCSIEPYDEKN- 530
            .:.|:|.|||:|::..|:......|:  ..|.|.|  .|.:  |:| ||.|..         ||
  Rat   453 DSVVLLRARPVITVDVSIFLPGSINI--TAPQCHDGQQPVNCLNVTVCFRFHG---------KNV 506

  Fly   531 -KELRLAYSVEAETFDHLK-KFSRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANTRD 593
             .|:.|.|::.|:.....| :..||:|.........|..|:...|.:  ..|.....::|...:|
  Rat   507 PGEIGLNYNLTADVAQKEKGQLPRVYFVLLGETAGQVSERLQLTHMD--EVCHHYVAHVKRRVQD 569

  Fly   594 IQTPVRFRLKYSLVEPPLA--DSALVRLNPIL-----------DQTQAHVDFEGTFQKDCGDDDL 645
            :.:|:.|...|||.|..:.  |..|..|.|:|           :||        .|:::|..:|
  Rat   570 VISPIVFEAAYSLGEHVIGEEDRELPDLTPVLRWKKGQRIAQKNQT--------VFERNCRSED- 625

  Fly   646 CESNLIIRVEPNITESSGNEYT--LILDETE-LEVRINVSNLADSAYEA--------QLFIAHQA 699
            |.::|.:|  ..:..||.:|.|  |.|...: :.:.|::|||.|.||:|        :||..:
  Rat   626 CAADLQLR--GKLLLSSVDEKTTHLALGAVKNISLNISISNLGDDAYDANVSFNVSRELFFIN-- 686

  Fly   700 GVSYVATKKPTNATCNSYNTTLVACSLGNPMLRDTTTF-VTIRFQPKGLEPSEKIMLFHIFANTT 763
                :..|:....:|....:..:.||:|.|.:|..:.: .::.|....|...|:|:.|.:.|.:.
  Rat   687 ----MWQKEEMGISCELLESDFLKCSVGFPFMRSKSKYEFSVIFDTSHLSGEEEILSFIVTAQSG 747

  Fly   764 SKLVGPERPER------DLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGPM 822
            :.    ||.|.      .|.:.:|.....:..|...| .||..|.||      .|:..|:
  Rat   748 NM----ERSEALHDNTLTLTIPLVHEVDTSITGIVSP-TSFVYGESV------DASNFIQ----- 796

  Fly   823 GMDDVGSQVHHM-----FTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEV 882
             :||  .:.|..     ..::|.||||.|...:.|.:|..|  .|....       :.||..:.|
  Rat   797 -LDD--QECHFQPVNITLQVYNMGPSTLPGSSVSISFPSRL--SPGGAE-------MFQVQDMVV 849

  Fly   883 SQ--GECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRD 945
            ||  |.|.:              :.||.....|.:            .:::.|:..:::|.|
  Rat   850 SQEKGNCSL--------------QRNPTPCIIPQE------------QENIFHTIFAFFSKS--- 885

  Fly   946 DHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILN 1010
                                                  |:|    .|||.|..:.|:.:.|::..
  Rat   886 --------------------------------------GRK----VLDCEKTGSFCLTLHCNLSA 908

  Fly  1011 MPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYPELR 1075
            :|. .|::.:....|.|:.::.: .....::..:.|..::..:..|..:.:.|.|.....:..|.
  Rat   909 LPK-EESRAIDLYMLLNTEILKK-DSSSVIQFMARAKVKVEPALRVVEIANGNPEETLVVFEALH 971

  Fly  1076 N-QQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGNLEKMNEEKPFLAPS 1139
            | :.|...:.| ||.:.::.|:|:..|:..:|||:|||:|                ..|..:...
  Rat   972 NLEPRGYVVGW-IIAISLLVGILIFLLLAVLLWKMGFFRR----------------RYKEIIEAE 1019

  Fly  1140 KNTHHVFXQEGTVGWDLVRRRR 1161
            ||      :|....||.|::.:
  Rat  1020 KN-----RKENEEAWDWVQKNQ 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	20/64 (31%)
		Int_alpha	317..368	CDD:214549	19/50 (38%)
		Int_alpha	378..428	CDD:214549	22/51 (43%)
		Int_alpha	446..491	CDD:214549	24/44 (55%)
		Integrin_alpha2	479..1006	CDD:285619	126/572 (22%)
Itga9	XP_038938627.1	Int_alpha	45..102	CDD:214549	20/62 (32%)
		Int_alpha	245..295	CDD:214549	21/50 (42%)
		Int_alpha	301..347	CDD:214549	19/46 (41%)
		Int_alpha	362..415	CDD:214549	22/52 (42%)
		Int_alpha	425..>467	CDD:214549	23/41 (56%)
		Integrin_alpha2	460..904	CDD:400650	126/572 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910