DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and itga10

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_003200204.1	Gene:	itga10 / 572348	ZFINID:	ZDB-GENE-100922-54	Length:	1170	Species:	Danio rerio

Alignment Length:	1365	Identity:	279/1365 - (20%)
Similarity:	463/1365 - (33%)	Gaps:	479/1365 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ILIILQCVLTCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNRQP 85
            |.|:|:.:..|  ||::.:.|.:..|...:.||:||..|   :.||   ...:|||||.|   .|
Zfish    12 ITILLKGLCEC--FNIDVKRPRIFSGPEDALFGFSVLQH---DDNG---EKLLLVGAPWD---GP 65

  Fly    86 NTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQANGSG 150
            .....|.:::|.:.....:|.:| ..|...|.:.      :..:|... :|:|:  .|..::|
Zfish    66 QNNRKGDIYKCIVEDENSNCSKV-NLGENAFQNV------SRNLKNSH-LGMTL--TPTDSDG-- 118

  Fly   151 GKVIVCAHRYMYIVRENRYGQGLCYLLTNDLQFEEVHEPCKGR---------------------- 193
              .:.||..:......:.:..|:|..:|:|::..:|..|...|
Zfish   119 --FLACAPLWSQECGTSLFSTGICASVTSDMEPNDVIAPTAQRCTTYMDIVIVLDGSNSIYPWYE 181

  Fly   194 ---------------PVQRQ-----------HE-------------------------------- 200
                           |.|.|           ||
Zfish   182 VQNFLSNILSKFHISPEQMQVGVLQYGEISVHEWSLRDYQTTADVVEAAKNISRQEGRETRTAYA 246

  Fly   201 -----------DYGLCQAGT--------------------------------------------- 209
                       |.|..:..|
Zfish   247 IQMACTEAFSPDRGAREGATKVMIVVTDGESHDGEDLPEALIECEKRNITRYAIAVLGHYIRRQQ 311

  Fly   210 --------------------------SAALLD--------------------------------- 215
                                      .|||.|
Zfish   312 DPETFINEIKYISSDPDEKYFFNVTDEAALNDIVDALGDRIFSLEGTLGYNESAFLMEMSQIGFS 376

  Fly   216 ----DDTMVLGSPGPYTWRGSIWVTQVGG------EYLQRDKTTYYSDHSDLNSPVDKYSYLGMS 270
                ||.::.|..|.|.|.|.|......|      |..:::......:|:         :|||.:
Zfish   377 THILDDGILFGMVGAYDWEGGILKESKEGQLMPPREAFEKEFPLELKNHA---------AYLGYT 432

  Fly   271 VTG---GRFFGHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELATADING 332
            |:.   |.:  ...|.|||||.:..|:|::||.:.:..:.:...|:|||.||.||.|:...|::.
Zfish   433 VSSVVVGNW--RRLYVAGAPRFKHKGKVILFDLTPEGDVIITQALNGEQIGSYFGSEVCVVDVDQ 495

  Fly   333 DHRPD-LIVAAPLYF--TKTEGGAVYVY----------------QNIQDTLPMKYTLKLTGPLES 378
            |...| |::|||::.  ...|.|.|||:                |..||               :
Zfish   496 DGITDILLIAAPMFLGAGNKETGKVYVFCLDGDGFAPNGTLHSQQKAQD---------------A 545

  Fly   379 RFGLALANIGDLNKDNCEDLAVGAPYEGN--GVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQ 441
            |||.|:|...|||.|...||.||||.|.:  |.:|||.|....:..:..|:|..|.|      ..
Zfish   546 RFGYAMAVAPDLNHDGYTDLLVGAPLEDDHQGALYIYHGDEYYIIPQYKQRISGSSL------ST 604

  Fly   442 PIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPNTPGCL- 505
            .:|.||.|:|...|||.:...|:.:||  ..:||:|.:|.|:.|..|:..:. |:::.....||
Zfish   605 GLRYFGRSLSALLDLDGDELLDLAVGA--QGSAVLLKSRSIVQINVSLSFQP-HSINVIQKNCLR 666

  Fly   506 ---DDPASNLT-CFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKKFSRVFFFDRENKRTNVL 566
               |....|.| ||   ...|..|   .::.......|.|...|  :|.|....||..::|..::
Zfish   667 AGRDSACLNATVCF---LALSRSP---GSRGTYFDMQVGAMLDD--RKISARALFDSNSQRQTLM 723

  Fly   567 SRVVRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSALVRLNPILDQTQAHVD 631
            |..|||   |.|:|..:..:: .:|.|...|:.|.|::.:.:        ....|:||
Zfish   724 SISVRV---GETKCYILPFHV-FDTADYIRPISFTLRFKIND--------TESGPVLD------- 769

  Fly   632 FEG---------TFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRINVSNLADS 687
             ||         .|.||||:||:|.::|:::...:|:.:....|.:......|.|.:.:.|..::
Zfish   770 -EGWPTTHKKSIPFFKDCGEDDVCVTDLVLQAHMDISGTRQVPYVIRSPRRRLAVEVQLQNKLEN 833

  Fly   688 AYEAQLFIAHQAGVSYVATKKPTNA----TCNSYNTTLVACSLGNPMLRD------------TTT 736
            ||...|.:.:...:.:.......:|    .|.:..:...:|::..|:.|.            :.|
Zfish   834 AYNTSLTLHYSKNLHFSTLSIREDAQFKIECTALGSNSHSCNVSYPVFRSQSKVNFMLEFEFSCT 898

  Fly   737 FVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFYSG 801
            .:..:.|.:.:..|:.:......::.|.:|....:.|.||.:.                    |.
Zfish   899 SLISKVQMRLIASSDSVEREGTLSDNTVQLQSIVQYEPDLFIT--------------------SD 943

  Fly   802 SSVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGR 866
            |::.....:...|..||.||        :.:..|.:.|.|......:::.:..|
Zfish   944 SNLNRYEVHPTRTASEGTGP--------EFYTHFRVQNLGCYAVSNLELSVSLP----------- 989

  Fly   867 PVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSL 931
                                           .:|||.|...|.:.|
Zfish   990 -------------------------------AVASGDRVFAAVVDA------------------- 1004

  Fly   932 IHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNK 996
                     .||          |.:.|..:.:..:::|:....|....:..:.||.:::    |.
Zfish  1005 ---------FSH----------NASGVNCTIVNDISKLKSSQRDVRPLHPEDMKKTELM----NC 1046

  Fly   997 GATNCVRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDH 1061
            .::.||.:.|.|..:.....|.:.:..|:.:|..        |...|...|  |..||.:...:.
Zfish  1047 SSSWCVEVMCHIQQLLKGQTALIRITRRIHDSFF--------RQAKFKAVT--IVGSYQLSARES 1101

  Fly  1062 NNIEVETRAYPELRNQQ----RDTSIP---WLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTD 1119
            |.|.:...|.  ||...    :..|||   | |:|..|:||||||||:.::|||:|||.|.:..|
Zfish  1102 NLITMGNAAL--LRETTLEVLKGRSIPISLW-ILIGSIIGGLLLLALLVFILWKLGFFTRKQRKD 1163

Fly 1120 1119
Zfish 1164 1163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	18/62 (29%)
		Int_alpha	317..368	CDD:214549	20/69 (29%)
		Int_alpha	378..428	CDD:214549	22/51 (43%)
		Int_alpha	446..491	CDD:214549	17/44 (39%)
		Integrin_alpha2	479..1006	CDD:285619	97/556 (17%)
itga10	XP_003200204.1	Int_alpha	38..88	CDD:214549	17/58 (29%)
		vWA_integrins_alpha_subunit	164..344	CDD:238746	11/179 (6%)
		Int_alpha	480..>523	CDD:214549	16/42 (38%)
		Int_alpha	543..597	CDD:214549	24/68 (35%)
		Integrin_alpha2	640..1056	CDD:285619	97/556 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574894
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740