Protein Alignment mew and itga1

DIOPT Version :9

• Sequence 1: NP_001285196.1
• Gene: mew / 32275
• FlyBaseID: FBgn0004456
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: XP_021334930.1
• Gene: itga1 / 570868
• ZFINID: ZDB-GENE-091118-115
• Length: 1183
• Species: Danio rerio
• Alignment Length: 1391
• Identity: 325/1391 - (23%)
• Similarity: 513/1391 - (36%)
• Gaps: 497/1391 - (35%)

  Fly    19 LGILIILQCVLTCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNR 83
            |..|:.|...|:|:|.:.:.|:..  .|.....|||:|......|.      ..||:|:||  ..
Zfish    10 LAALLALLPWLSCFNVDEKNRMSF--SGPVEDMFGYTVQQFENSEG------KWVLIGSPL--TG 64

  Fly    84 QPNTTHSGALWRCPMTQRFDD-CEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQAN 147
            || ...:|.::||.:....|. ||:.:.       ||..:.|..:|:||:..||.|:..||   :
Zfish    65 QP-AKRTGDVYRCRVGSNSDSKCEKFLL-------SENTTIPNINEVKENMTMGTTLVVNP---D 118

  Fly   148 GSGGKVIVCAHRYMYIVRENRYGQGLC------YLLTNDL------------------------- 181
            |:|  .:.|..:|.|:..:.:|..|:|      :.:.|.:
Zfish   119 GNG--FLACGPQYGYMCGKQQYITGICSNVSSSFKVLNSIAPTVRECSQDMDIVIVLDGSNSIYP 181

  Fly   182 --------------------------------------QFEEVHEPCKGRPVQRQ---------- 198
                                                  ||....|..|.....||
Zfish   182 WDHITDFLVKFLQNIEIGPARVGIVSYGDDVGHVFNLSQFSNTKELVKNAADIRQRTGHKTMTAL 246

  Fly   199 --------------------------------HEDYGL------CQAG----TSAALLDD----- 216
                                            |:.:.|      ||..    .:.|:|.|
Zfish   247 GIDTARKEAFTVERGARPGVKKVMVIVTDGESHDHHNLKSVIDQCQEDGIERFAVAVLGDYNRQN 311

  Fly   217 --------------------------------------DTM------------------------ 219
                                                  ||:
Zfish   312 KSIDEIKKFIEEIEYIASETKSDHFFNVSDERALVTIVDTLGSKIFALEATSGKHTSSFEMEMSQ 376

  Fly   220 ------------VLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSDLNSPVDKY----SYLG 268
                        :||:.|.:.|.|:: |.|.|.|::...|.|::      |..|.:|    .|:|
Zfish   377 AGFSAHTSKAGVMLGAVGAFDWNGTV-VMQAGNEFVVPKKNTFH------NPSVQRYEGMAGYVG 434

  Fly   269 MSVTGGRFFGHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELATADINGD 333
            ..|........:.|..||||....|:|.::....:| :.:...|.|||.||.||..|.|.||:||
Zfish   435 YDVQSAYTPNGVLYITGAPRFNHSGRVTVYRFDGEN-VTIVQTLKGEQIGSYFGSVLQTHDIDGD 498

  Fly   334 HRPD-LIVAAPLYF--TKTEGGAVYVYQ-NIQDTLPMKYTLKLTG-------------------P 375
            :..| |:||||::.  .:.|.|.||||: |.......:.|||...                   |
Zfish   499 NYTDILLVAAPMFMGPERDEQGQVYVYKLNESGLFEHEMTLKPVNQTCCSGHSHNNCKIVSKNEP 563

  Fly   376 LESRFGLALANIGDLNKDNCEDLAVGAPYEGN--GVVYIYLGSSQGLNSKPAQKIQASELGGTIP 438
            ..:|||.|:|.:.|||.|...|:.:|:|.|.:  |.||||.||.:.:..|..|:|.|   ||
Zfish   564 CGARFGTAIAAVPDLNLDKFSDIVIGSPLENDHRGAVYIYHGSQKSIKEKYVQRIAA---GG--- 622

  Fly   439 NGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSA------AVILLAR----PI-ISIQTSVQRK 492
            :|:.::.||.||.|..||:|:...||.||....:|      ...|||.    || |::|.:.|
Zfish   623 DGESMKFFGQSIHGIMDLNDDGIIDVTIGGIGGAALYWSRDVAELLAEMTFDPIKINLQHTCQ-- 685

  Fly   493 ELHNMDPNTPGCLDDPASNLTCFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKKFSRVFFFD 557
             :|.   .|..|:    ....||.:|    |:...|.|....:.||:   |.|.|:..:|..|.:
Zfish   686 -VHG---KTTVCV----KTRVCFKYR----IKSVKEMNTGTVIRYSL---TLDSLRAVARGRFNE 735

  Fly   558 RENKR----TNVLSRVVRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEP---PLADSA 615
            .|::|    .::.::..|.||           :..::..|.:.|:...|::.|.:.   |:.|.
Zfish   736 TEDRRLQKNESIRNKFCREHT-----------FYTSDKLDFRDPIMVTLEFGLADEDKGPVLDG- 788

  Fly   616 LVRLNPILDQTQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLIL--DETELEVR 678
              .|...|::|.|.|        |||.::.|.:||.::...||:       :|::  ::.:..|.
Zfish   789 --ELPTSLNKTIALV--------DCGSNEKCVANLHLQASANIS-------SLLIKSNQEKFYVN 836

  Fly   679 INVSNLADSAYEAQLFIAHQAGVSYVATKKPTNATCNSYNTTLVACSLGNPML--RDTTTFVTIR 741
            |::.|..|:||..::.::|...::||.. :|.:..|.: |.|.:.|::|.|.|  :|..|| .|:
Zfish   837 IDIKNTGDNAYNTKVTLSHTENINYVKV-EPKDKDCET-NHTRIVCAVGYPFLKTKDRETF-KIQ 898

  Fly   742 FQPKGLEPS--EKIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSV 804
            |:|   .||  .|.::.::.|.|.|     |:.:..|        |.||....||.:...|....
Zfish   899 FEP---NPSLIRKDIVINVTATTDS-----EQSDSAL--------KRNFETIIIPVRHEASMRFT 947

  Fly   805 AN-----------------SVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVI 852
            ||                 ||.|..:.            :|.:|...:||..:....:|.|::.|
Zfish   948 ANKYMKEDHIILKEKETIPSVFNHTSV------------IGDEVKISYTIEKDPDMPSPPVKLTI 1000

  Fly   853 HWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQG-ECHVAKEYVNPLNLASGSRENPAYLSAPAQM 916
            .:||...:.       .:||||..   :..:.| .|  :.:::|||.:.
Zfish  1001 MFPYQTSAK-------NFLLYLTD---LSYTAGIRC--SADWINPLKIQ---------------- 1037

  Fly   917 RMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNA 981
               ||:. ||.|                                      |:.|.|
Zfish  1038 ---PSKP-HSLN--------------------------------------TKKETL--------- 1051

  Fly   982 ANGKKQDIVELDCNKGATNCVRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTA 1046
                  .|..|.|.:....|....|.|   |:....|:....|||..|.:    :.|...|....
Zfish  1052 ------SIYLLSCKEKENPCQSFSCFI---PSGDFNQINTTFRLWRPTFI----KGEFSTIHMAV 1103

  Fly  1047 TAQI-PESYGVEVMDHNNIEVETRAYPELRNQ-QRD--TSIPWLIIILGIVGGLLLLALVTYVLW 1107
            .|:: .::..:.|::.|   ::||   |:|.| .:|  |.||..||||.|:.|||:||||.:.||
Zfish  1104 DAKLETQNTDLFVLNEN---IKTR---EVRIQVTKDIRTGIPLWIIILSILIGLLILALVIFALW 1162

  Fly  1108 KVGFFKRIRPTDPTLSGNLEKMNEEK 1133
            |.|||||         .::|:|||:|
Zfish  1163 KAGFFKR---------KSVEEMNEDK 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	18/63 (29%)
		Int_alpha	317..368	CDD:214549	23/54 (43%)
		Int_alpha	378..428	CDD:214549	22/51 (43%)
		Int_alpha	446..491	CDD:214549	20/55 (36%)
		Integrin_alpha2	479..1006	CDD:285619	119/562 (21%)
itga1	XP_021334930.1	vWFA	167..348	CDD:320736	13/180 (7%)
		Int_alpha	482..532	CDD:214549	23/49 (47%)
		Int_alpha	565..618	CDD:214549	22/52 (42%)
		Integrin_alpha2	661..1070	CDD:312071	121/570 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574976
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740