Protein Alignment mew and itga11b

DIOPT Version :10

• Sequence 1: NP_001285196.1
• Gene: mew / 32275
• FlyBaseID: FBgn0004456
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: XP_695559.9
• Gene: itga11b / 567175
• ZFINID: ZDB-GENE-071009-4
• Length: 1186
• Species: Danio rerio
• Alignment Length: 1372
• Identity: 287/1372 - (20%)
• Similarity: 473/1372 - (34%)
• Gaps: 475/1372 - (34%)

  Fly    30 TCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNRQPNTTHSGALW 94
            ||:|.: .:|..::| |...:.|||:|..|   ||:|   ...:|||||.:.:.:..|   |.::
Zfish    22 TCFNID-TRRAKVIK-GSREAQFGYTVQQH---EADG---QKWLLVGAPFETSGEHQT---GDVY 75

  Fly    95 RCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQANGSGGKVIVCAHR 159
            |||:..:..:|.::.. |:       :|.....|.::...:|:|:.:||     .....:.|...
Zfish    76 RCPLESKRTNCTRLHL-GK-------ISLNNVSERRDKMRLGMTLATNP-----KDNSFVACGPL 127

  Fly   160 YMYIVRENRYGQGLC----------------------YL---------------------LTNDL 181
            :.|....:.|..|:|                      |:                     |.|.|
Zfish   128 WSYECGSSYYSTGICSRVDSNFNFTHSIAPAYQRCETYMDIVIVLDGSNSIYPWYEVQDFLINVL 192

  Fly   182 Q-------------------------------FEEVHEPCK------------------------ 191
            |                               .:||....|
Zfish   193 QKFYIGPGQIQVGVVQYGERVVNEFRLDDFRTVDEVVAAAKNIDQRGGEETRTALGINVARTQAF 257

  Fly   192 ---GRP-----------------------VQRQHED----YGLC--------------------- 205
               |||                       |:...:|    ||:.
Zfish   258 KHGGRPDAKKVMIVITDGESHDSPDLKAAVEESEKDNITLYGIAVLGYYNRRGINPEAFLREIKF 322

  Fly   206 -----------------------------------------------QAGTSAALLDDDTMVLGS 223
                                                           |||.|:.:::|..:| |:
Zfish   323 IATDPDEHFFSVTDESALKDIVDALGEKIFSLEGTNQNGTAFGLQMSQAGFSSHIVEDGILV-GA 386

  Fly   224 PGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSDLNSPVDKYSYLGMSVTG--GRFFGHMSYAAGA 286
            .|.|.|.|::......|:.:. .|::|..:..:  ...:..:|||..|:.  ....|.: |.|||
Zfish   387 VGAYDWNGAVLKETRHGKVIP-PKSSYMKEFPE--ELKNHGAYLGYMVSSVVSAHHGQL-YVAGA 447

  Fly   287 PRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELATADINGDHRPD-LIVAAPLYFTK-T 349
            ||....|:||||..:....:.:...|.|:|.||.:|.|||..|::.|...| |:|.||:||.: .
Zfish   448 PRFNHTGKVVIFTLTNSGNLTILYSLYGKQIGSYYGSELAPIDVDDDGLTDLLLVGAPMYFYRGW 512

  Fly   350 EGGAVYVYQ-NIQDTLPMKYTLKLTGPLE----SRFGLALANIGDLNKDNCEDLAVGAPYEGN-- 407
            |.|.||:|. .:|.:.....||   ||.|    ||||.|::.:.|||.|...:|.||||.|.|
Zfish   513 EKGKVYIYTVGLQGSFIPDGTL---GPSEHSHDSRFGAAMSALPDLNGDGFSELVVGAPLEDNHR 574

  Fly   408 GVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSS 472
            |.:|::.|....:.:|..|:|...||.   |.   :|.||.|:.|..||:.:...|:.:|:|  .
Zfish   575 GAIYLFYGLKNSIQTKYKQRISGIELA---PG---LRYFGRSVHGMMDLNGDGLVDLSVGSF--G 631

  Fly   473 AAVILLARPIISIQTSV----QRKELHNMDPNTPGCLDDPASNLTCFTFRACCSIEP----YDEK 529
            |||:|.:|.::.:...|    .:..:.|.|     |:.. ...::|.....|.::..    .|.|
Zfish   632 AAVLLWSRSVVRVGIGVHFEPSKINVFNKD-----CIRG-GREVSCMLATVCLNVTARTPMTDPK 690

  Fly   530 NKELRLAYSVEAETFDHLKKFSRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANTRDI 594
            ...||.::.     |:....|.|......|..| :|..|....|      ||.:..::...| |.
Zfish   691 RVALRYSFG-----FEETGYFPRAVLDSTEESR-DVTLRPAAQH------CQQLHFHVHEVT-DY 742

  Fly   595 QTPVRFRLKYSLVEPPLADSALVRLNPILDQ-TQAHVDFEGTFQKDCGDDDLCESNLI------- 651
            ..|:.|.:...|..   ||.     .|:||. ....:..|..|...|.:||.|..|||
Zfish   743 TRPLTFTVNVGLQR---ADE-----GPVLDDGWPTSLRSELPFWNGCDNDDQCVPNLILQSSSDL 799

  Fly   652 -----------------------IRVEPNITESSGNEYTLILDETELEVRINVSNLADSAYEAQL 693
                                   |:....:.|||..:   ::.||.||      |..::||.:.|
Zfish   800 LDLREFCSRDERSSWPPCVDQSSIKTPERLVESSRRK---VVVETHLE------NRGENAYNSIL 855

  Fly   694 FIAHQAGV--SYVATKKPTNAT--C-NSYNTTLV-ACSLGNPMLR-DTTTFVTIRFQPKGLEPSE 751
            .|.|...:  |.:..|.|::..  | ||.:|:|. .|::..|.:| ....:..:.|:
Zfish   856 HITHSPNLHFSSLVVKAPSDIAIECPNSDDTSLYRTCNVSAPFMRASAQVYFRLEFE-------- 912

  Fly   752 KIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDI 816
                                                           :|.|...|.|..:.....
Zfish   913 -----------------------------------------------FSRSVFLNYVNISLRVSS 930

  Fly   817 EGHGPMGMDDVGSQVHH--------MFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLY 873
            ||......|:: :.:||        :||                          :...|.::.:.
Zfish   931 EGEEMFPEDNI-NNIHHNLRYEADILFT--------------------------RDSSPSRFEIK 968

  Fly   874 LEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSY 938
            .||..:|.|..|.         |.|| |...:|         :.:|| .|...|..::....|..
Zfish   969 PEQAHSVSVGSGP---------PFNL-SYQIQN---------LGLFP-VSELLFTLNVFAVTRKA 1013

  Fly   939 YSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDC--NKGATNC 1001
            .:..|..|              .:::::.  ..|...|....|.:..:::.:.|:.  |...::.
Zfish  1014 NTLLHLSD--------------LYIQQMP--GSLCSFPRVITAGSSSQEEDLSLNAHMNASTSDA 1062

  Fly  1002 VRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPES-----YGVEVMDH 1061
            :..:|. .|:...::..:.|...|...||::  .:.:|:.:..|||.::..|     :....|.|
Zfish  1063 LLAQCR-FNLSPQADVSITVTGWLNLHTLLA--VKFKRLDLVMTATVELSPSNPMFLHEERPMRH 1124

  Fly  1062 NNIEVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGNL 1126
            ..:|:         .::.|..||..:||...:|||.||||:...|||:|||.|.:........|
Zfish  1125 IILEI---------RKEEDYRIPVWVIIGSTLGGLQLLALLVLALWKLGFFHRQKRKRDEQEAN- 1179

  Fly  1127 EKMNEEK 1133
            ||..|::
Zfish  1180 EKTAEDR 1186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	19/62 (31%)
		Int_alpha	317..368	CDD:214549	21/53 (40%)
		Int_alpha	378..428	CDD:214549	21/51 (41%)
		Int_alpha	446..491	CDD:214549	15/48 (31%)
		Integrin_alpha2	480..1006	CDD:462478	100/581 (17%)
itga11b	XP_695559.9	None