DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and itga11b

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_695559.7	Gene:	itga11b / 567175	ZFINID:	ZDB-GENE-071009-4	Length:	1219	Species:	Danio rerio

Alignment Length:	1372	Identity:	288/1372 - (20%)
Similarity:	473/1372 - (34%)	Gaps:	475/1372 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNRQPNTTHSGALW 94
            ||:|.: .:|..::| |...:.|||:|..|   ||:|   ...:|||||.:.:.:..|   |.::
Zfish    55 TCFNID-TRRAKVIK-GSREAQFGYTVQQH---EADG---QKWLLVGAPFETSGEHQT---GDVY 108

  Fly    95 RCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQANGSGGKVIVCAHR 159
            |||:..:..:|.::.. |:       :|.....|.::...:|:|:.:||     .....:.|...
Zfish   109 RCPLESKRTNCTRLHL-GK-------ISLNNVSERRDKMRLGMTLATNP-----KDNSFVACGPL 160

  Fly   160 YMYIVRENRYGQGLC----------------------YL---------------------LTNDL 181
            :.|....:.|..|:|                      |:                     |.|.|
Zfish   161 WSYECGSSYYSTGICSRVDSNFNFTHSIAPAYQRCETYMDIVIVLDGSNSIYPWYEVQDFLINVL 225

  Fly   182 Q-------------------------------FEEVHEPCK------------------------ 191
            |                               .:||....|
Zfish   226 QKFYIGPGQIQVGVVQYGERVVNEFRLDDFRTVDEVVAAAKNIDQRGGEETRTALGINVARTQAF 290

  Fly   192 ---GRP-----------------------VQRQHED----YGLC--------------------- 205
               |||                       |:...:|    ||:.
Zfish   291 KHGGRPDAKKVMIVITDGESHDSPDLKAAVEESEKDNITLYGIAVLGYYNRRGINPEAFLREIKF 355

  Fly   206 -----------------------------------------------QAGTSAALLDDDTMVLGS 223
                                                           |||.|:.:::|..:| |:
Zfish   356 IATDPDEHFFSVTDESALKDIVDALGEKIFSLEGTNQNGTAFGLQMSQAGFSSHIVEDGILV-GA 419

  Fly   224 PGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSDLNSPVDKYSYLGMSVTG--GRFFGHMSYAAGA 286
            .|.|.|.|::......|:.:. .|::|..:..:  ...:..:|||..|:.  ....|.: |.|||
Zfish   420 VGAYDWNGAVLKETRHGKVIP-PKSSYMKEFPE--ELKNHGAYLGYMVSSVVSAHHGQL-YVAGA 480

  Fly   287 PRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELATADINGDHRPD-LIVAAPLYFTK-T 349
            ||....|:||||..:....:.:...|.|:|.||.:|.|||..|::.|...| |:|.||:||.: .
Zfish   481 PRFNHTGKVVIFTLTNSGNLTILYSLYGKQIGSYYGSELAPIDVDDDGLTDLLLVGAPMYFYRGW 545

  Fly   350 EGGAVYVYQ-NIQDTLPMKYTLKLTGPLE----SRFGLALANIGDLNKDNCEDLAVGAPYEGN-- 407
            |.|.||:|. .:|.:.....||   ||.|    ||||.|::.:.|||.|...:|.||||.|.|
Zfish   546 EKGKVYIYTVGLQGSFIPDGTL---GPSEHSHDSRFGAAMSALPDLNGDGFSELVVGAPLEDNHR 607

  Fly   408 GVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSS 472
            |.:|::.|....:.:|..|:|...||.   |.   :|.||.|:.|..||:.:...|:.:|:|  .
Zfish   608 GAIYLFYGLKNSIQTKYKQRISGIELA---PG---LRYFGRSVHGMMDLNGDGLVDLSVGSF--G 664

  Fly   473 AAVILLARPIISIQTSV----QRKELHNMDPNTPGCLDDPASNLTCFTFRACCSIEP----YDEK 529
            |||:|.:|.::.:...|    .:..:.|.|     |:.. ...::|.....|.::..    .|.|
Zfish   665 AAVLLWSRSVVRVGIGVHFEPSKINVFNKD-----CIRG-GREVSCMLATVCLNVTARTPMTDPK 723

  Fly   530 NKELRLAYSVEAETFDHLKKFSRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANTRDI 594
            ...||.::.     |:....|.|......|..| :|..|....|      ||.:..::...| |.
Zfish   724 RVALRYSFG-----FEETGYFPRAVLDSTEESR-DVTLRPAAQH------CQQLHFHVHEVT-DY 775

  Fly   595 QTPVRFRLKYSLVEPPLADSALVRLNPILDQ-TQAHVDFEGTFQKDCGDDDLCESNLI------- 651
            ..|:.|.:...|..   ||.     .|:||. ....:..|..|...|.:||.|..|||
Zfish   776 TRPLTFTVNVGLQR---ADE-----GPVLDDGWPTSLRSELPFWNGCDNDDQCVPNLILQSSSDL 832

  Fly   652 -----------------------IRVEPNITESSGNEYTLILDETELEVRINVSNLADSAYEAQL 693
                                   |:....:.|||..:   ::.||.||      |..::||.:.|
Zfish   833 LDLREFCSRDERSSWPPCVDQSSIKTPERLVESSRRK---VVVETHLE------NRGENAYNSIL 888

  Fly   694 FIAHQAGV--SYVATKKPTNAT--C-NSYNTTLV-ACSLGNPMLR-DTTTFVTIRFQPKGLEPSE 751
            .|.|...:  |.:..|.|::..  | ||.:|:|. .|::..|.:| ....:..:.|:
Zfish   889 HITHSPNLHFSSLVVKAPSDIAIECPNSDDTSLYRTCNVSAPFMRASAQVYFRLEFE-------- 945

  Fly   752 KIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDI 816
                                                           :|.|...|.|..:.....
Zfish   946 -----------------------------------------------FSRSVFLNYVNISLRVSS 963

  Fly   817 EGHGPMGMDDVGSQVHH--------MFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLY 873
            ||......|:| :.:||        :||                          :...|.::.:.
Zfish   964 EGEEMFPEDNV-NNIHHNLRYEADLLFT--------------------------RDSSPSRFEIK 1001

  Fly   874 LEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSY 938
            .||..:|.|..|.         |.|| |...:|         :.:|| .|...|..::....|..
Zfish  1002 PEQAQSVSVGSGP---------PFNL-SYQIQN---------LGLFP-VSELLFTLNVFAVTRKA 1046

  Fly   939 YSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDC--NKGATNC 1001
            .:..|..|              .:::::.  ..|...|....|.:..:::.:.|:.  |...::.
Zfish  1047 NTLLHLSD--------------LYIQQMP--GSLCSFPRVITAGSSSQEEDLSLNAHMNASTSDA 1095

  Fly  1002 VRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPES-----YGVEVMDH 1061
            :..:|. .|:...::..:.|...|...||::  .:.:|:.:..|||.::..|     :....|.|
Zfish  1096 LLAQCR-FNLSPQADVSITVTGWLNLHTLLA--VKFKRLDLVMTATVELSPSNPMFLHEERPMRH 1157

  Fly  1062 NNIEVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGNL 1126
            ..:|:         .::.|..||..:||...:|||.||||:...|||:|||.|.:........|
Zfish  1158 IILEI---------RKEEDYRIPVWVIIGSTLGGLQLLALLVLALWKLGFFHRQKRKRDEQEAN- 1212

  Fly  1127 EKMNEEK 1133
            ||..|::
Zfish  1213 EKTAEDR 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	19/62 (31%)
		Int_alpha	317..368	CDD:214549	21/53 (40%)
		Int_alpha	378..428	CDD:214549	21/51 (41%)
		Int_alpha	446..491	CDD:214549	15/48 (31%)
		Integrin_alpha2	479..1006	CDD:285619	101/582 (17%)
itga11b	XP_695559.7	Int_alpha	73..123	CDD:214549	19/58 (33%)
		vWA_integrins_alpha_subunit	199..376	CDD:238746	14/176 (8%)
		Int_alpha	574..628	CDD:214549	21/53 (40%)
		Int_alpha	639..>665	CDD:214549	9/27 (33%)
		Integrin_alpha2	671..1071	CDD:312071	98/553 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810