DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and itga6l

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_021336955.1	Gene:	itga6l / 555254	ZFINID:	ZDB-GENE-040914-57	Length:	786	Species:	Danio rerio

Alignment Length:	926	Identity:	257/926 - (27%)
Similarity:	386/926 - (41%)	Gaps:	256/926 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 GHMSYAAGAPRSEGHGQVVIF---DKSTDNPIPVHSILDGEQFGSSFGYELATADINGDHRPDLI 339
            |.::..||||||...|:|::.   |::....:.|..||.|....|||||:|...|:|.|...|::
Zfish     7 GELNVVAGAPRSNHSGEVLLLRPEDRTEARNLKVEHILRGPGLASSFGYDLTILDLNADGWDDIV 71

  Fly   340 VAAPLYFTKT----EGGAVYVYQN---------IQDTLPMKYTLKLTGPLESRFGLALANIGDLN 391
            |.||.:.:|.    .|||||:|.|         ||...       |.|..:|.||||:|::||||
Zfish    72 VGAPEFSSKNMDDDVGGAVYIYINQAEGQHWSHIQPVC-------LYGKKDSMFGLAVAHVGDLN 129

  Fly   392 KDNCEDLAVGAPYE--GNGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISISGNT 454
            :|..:|.|..||.|  |.|.||||.||:.|.:.||. .:.|.:        ..|:.||.|::||.
Zfish   130 QDGYQDFASSAPNEDSGRGRVYIYHGSAAGFHHKPT-VLDAGD--------HSIKLFGYSLAGNM 185

  Fly   455 DLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPNTPGCLDDPASNL------- 512
            |:|.|.||::.:|:| |...:|...:|:|:|:.::..         ||..:|..|.:.
Zfish   186 DMDSNGYPELAVGSF-SDTVLIYRTKPVINIEKTLTL---------TPNKIDFKAQDCKRKPCII 240

  Fly   513 ---TCFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKKFSRVFFFDRENKRTNVLSRVVRVHT 574
               :|||:    :.|| ...|.:||:.|.:||:|.               .:...:.||||.|::
Zfish   241 TAQSCFTY----TTEP-QTYNPKLRIEYKLEADTV---------------RRERGLPSRVVFVNS 285

  Fly   575 ---NGRTECQA------------VTGYIKANTRDIQTPVRFRLKYSLV--EPPLADSALVRLNPI 622
               |||.:.:|            :.|.|    :|..|.:...|..||.  .|......|..|.|:
Zfish   286 DAANGRQQLKAQRQKSCVQTKLRLLGEI----QDKLTSISISLSVSLPSDNPKQTIRNLPDLEPV 346

  Fly   623 LDQTQ-----AHVDFEGTFQKDCGDDDLCESNLIIR-----------------VEPNITESSGNE 665
            |:..|     |.|.|   ....||.|::|:|||.::                 :|..:...|..:
Zfish   347 LNTLQEKTSKAEVSF---LNSGCGSDNICQSNLQLQYSFCTKDQQQDQCDPLAMENGVPVISPGD 408

  Fly   666 YTLILDETELEVRINVSNL-ADSAYEAQLF-----IAHQAGVSYVATKK--PTNATCN-SYNTTL 721
            ..:.|:       :.|:|. .|.|:..||:     :.|   ::.|..||  .|...|| :.|.|.
Zfish   409 VNIALE-------VTVTNTGGDDAHHTQLYVMFPEVLH---LTSVVPKKNSVTQVQCNPNENRTQ 463

  Fly   722 VACSLGNPMLRD--TTTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERPERDLRVN----V 780
            ..|.||||:.||  .:.|:.:.        :||:.|....||.|..|       :.:.:.    |
Zfish   464 ADCQLGNPLKRDAEVSFFLMLN--------TEKLSLRVTAANVTLAL-------KTISIQDVPIV 513

  Fly   781 VRRAK------LNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFN 839
            |..||      ||..|.|.|.|.|:.|     .|.:..|...|       |||||.|.:.|.|||
Zfish   514 VAEAKIIFELHLNIIGLAKPSQLFFGG-----EVKDERAMKAE-------DDVGSLVQYEFRIFN 566

  Fly   840 EGP--STAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPL--NLA 900
            .|.  .:.....:.|.|       |::.:..:.||||.|:.....:...| ...|.:|.|  |:|
Zfish   567 IGRPLKSFGSAVLNIQW-------PKATKAGKRLLYLMQITDRGKNIIHC-TPSEAINTLRFNMA 623

  Fly   901 S--GSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFL 963
            |  |.||                ..|.|..|:|..:...:                      .||
Zfish   624 SSRGKRE----------------LERESGLKALASTSDFF----------------------PFL 650

  Fly   964 ERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNMPAL-SEAQVVVKARLWN 1027
                                |.|:....|.| ....:||.:.|.   :.|| |.|.:::.|||||
Zfish   651 --------------------GNKRKYKTLTC-ADELSCVELRCP---LEALDSSAVILLHARLWN 691

  Fly  1028 STLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYPELRNQQRDTSIPWLIIILGI 1092
            :|.:.||..:..:.|...|:..:..:.|...|..::.:|:...:.| |.....:.:||.:|:|.:
Zfish   692 NTFLQEYSSLNYLDIILNASLTLNGTQGNIGMQPSDTKVKLTVFAE-RRPALLSRVPWWLILLSV 755

  Fly  1093 VGGLLLLALVTYVLWK 1108
            |..||||||:.|:|||
Zfish   756 VTALLLLALLFYLLWK 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549
		Int_alpha	317..368	CDD:214549	23/63 (37%)
		Int_alpha	378..428	CDD:214549	27/51 (53%)
		Int_alpha	446..491	CDD:214549	17/44 (39%)
		Integrin_alpha2	479..1006	CDD:285619	140/602 (23%)
itga6l	XP_021336955.1	Int_alpha	51..108	CDD:214549	23/56 (41%)
		Int_alpha	115..159	CDD:214549	24/43 (56%)
		VCBS	127..197	CDD:316075	32/78 (41%)
		Integrin_alpha2	209..672	CDD:312071	140/602 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5161
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1884
OMA	1	1.010	-	-		QHG46425
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	1	1.000	-	-		FOG0001200
OrthoInspector	1	1.000	-	-		otm26039
orthoMCL	1	0.900	-	-		OOG6_102503
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X929
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980