DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and itga2b

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001003857.1	Gene:	itga2b / 445380	ZFINID:	ZDB-GENE-051031-1	Length:	1037	Species:	Danio rerio

Alignment Length:	1184	Identity:	315/1184 - (26%)
Similarity:	483/1184 - (40%)	Gaps:	262/1184 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LGILIILQCVLTCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNR 83
            |.|||....:   ..|||:.....|..|...|:||:||..:     ...:|:..|:||||.....
Zfish    12 LSILIFTNHI---RGFNLDLNQYTVFSGPEDSYFGFSVDFY-----QSSSKSVSVVVGAPRANTN 68

  Fly    84 QPNTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEI----------KEDQWMGVT 138
            |...:|.|:::.||...|...|:.:      |||.:     |::.|          |.:||:|.:
Zfish    69 QSGVSHGGSVFMCPWATRGQSCQTL------NFDQK-----GDENITFGNMLLMAHKSNQWLGAS 122

  Fly   139 VRSNPLQANGSGGKVIVCA---HRYMYIVRENRYGQ--GLCYLL---TNDLQFEEVHEPCKGRPV 195
            ||:       ....::.||   |..:.:.:|.....  |.|.||   |.:|   ..:.||:...|
Zfish   123 VRT-------YNNYILACAPLFHWNVLVDQEEAMNTPVGNCQLLNMKTGEL---ANYAPCREEYV 177

  Fly   196 ----QRQHEDYGLCQAGTSAALLDDDTMVLGSPGPYTWRGSIWVTQV------GGEYLQR----- 245
                .|.:.|...|:||.:..:..:..:|||:||.|.::|.|....:      |..:..:
Zfish   178 YAIYTRGYPDRRYCEAGFTTDITKNGRVVLGAPGGYYFQGQIITASLVNIMSSGSSFTPKHSMNG 242

  Fly   246 -DKTTYYSDHSDLNSPVDKYSYLGMSVTGGRFFGH--MSYAAGAPRSEGH--GQVVIFDKSTDNP 305
             .||....|:.||        |||.||..|:|...  ..|..|.| ::.|  |.|.|.:.:| .|
Zfish   243 ETKTPQRRDYYDL--------YLGYSVAAGKFNNDNIPDYVVGVP-NDLHTAGSVKIINGAT-VP 297

  Fly   306 IPVHSILDGEQFGSSFGYELATADINGDHRPDLIVAAPLYFTK------TEGGAVYVYQNIQD-T 363
            :.:...:.|.|..|.||:.:|..|||.|...|:::.|||:..:      .|.|.||||....| :
Zfish   298 LQIMKAISGTQIASYFGHSVAVTDINRDGWDDILIGAPLFMEQLSTQKFREVGQVYVYLQRNDFS 362

  Fly   364 LPMKYTLKLTGPLE-SRFGLALANIGDLNKDNCEDLAVGAP--YEGNGVVYIYLGSSQGLNSKPA 425
            ...:....|.|... .|||.|:|.:|||:.|...|:|||||  .:| |.|:||||.|.||:::..
Zfish   363 FASRPNQILAGTYAYGRFGSAIAPLGDLDHDGFNDVAVGAPGSVDG-GKVFIYLGKSGGLSTQYV 426

  Fly   426 QKIQASELGGTIPNGQPIRT------FGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIIS 484
            |.|::           |.|:      ||.||.|.||:|||.|||::|||:.:|..|...|:.::.
Zfish   427 QVIES-----------PFRSLIDPPMFGFSIRGGTDIDDNGYPDLIIGAWGASKVVTYRAQAVVR 480

  Fly   485 IQTSVQ-RKELHNMDPNTPGC-LDDPASNLTCFTFRACCSIEPYDEK-----NKELRLAYSVEAE 542
            .|..:. ..:|  ::|....| |....:.:||||..||..:..:...     |.||:|
Zfish   481 TQARLSFFPDL--LNPEDKFCQLQQSGTYITCFTIMACIRVSGHRIPQQIVFNTELQL------- 536

  Fly   543 TFDHLKK--FSRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYS 605
              |.:|:  ..|....|.....||.   .:.|..|.|..|:..|.|:....:|..:|:...:.||
Zfish   537 --DRMKQSMARRTLLLDSNQPYTNF---QISVDRNSRDVCRNFTAYLLPEFKDKLSPIFISVNYS 596

  Fly   606 LVEPPLADSALVRLNPILDQTQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLIL 670
                 ||||.    |.:|......|. :.....:||.|::|..:|.::.   :|.:   |..||.
Zfish   597 -----LADSQ----NAVLHGQSVAVG-QTRIILNCGPDNVCIPDLQLKA---VTST---EPILIG 645

  Fly   671 DETELEVRINVSNLADSAYEAQLFIAHQAGVSY-------------VATKKPTNATCNSYNTTLV 722
            ||....:.|...|..:.|||.:|:|:..|...|             |..:|..|      .:.:|
Zfish   646 DENPALLIIEAENQGEGAYETELYISPPANTHYQGVLSNHEDFSALVCGQKKEN------GSVIV 704

  Fly   723 ACSLGNPMLRDTTTFVTIRFQPKGLEPSEKIMLFHI------FANTTSKLVGPERPERDLRVNVV 781
            .|.||||:.........:.|....||..|..:.|.:      ..|:.|.||       .|:|||.
Zfish   705 VCDLGNPLEAGQQLKAGLYFSMGDLEQVENHITFQMQIRSKNSQNSDSNLV-------QLQVNVT 762

  Fly   782 RRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAP 846
            ..|.|..||          .||..:.|...:..:.:.: |..:|:||..:.|::.:.|.|||..
Zfish   763 AVASLEMRG----------VSSPVDCVLPISKWESKDY-PEDLDEVGPLIEHVYELRNRGPSPV- 815

  Fly   847 KVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLS 911
            .|::.:.:|.|        :...||||:....:.|:.  .|......::|..|......|.....
Zfish   816 NVKLTLEFPVS--------QNESYLLYVFANASEELI--SCQTDYANIDPRRLVKQESTNITVAE 870

  Fly   912 APAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDP 976
            .            |.|||.               |.|..|::.:
Zfish   871 V------------HHFNKR---------------DLSQKTENEQ--------------------- 887

  Fly   977 ESSNAANGKKQDIVELDCNKGATNCVRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVR 1041
                    :.|..|.::|: .:..||..:|....:.....|.|.|.:|||..|.:.. |.|..|
Zfish   888 --------QWQHTVHVNCS-SSEQCVVFDCVAAGLQRDERAIVRVMSRLWVQTFLKR-PYVNYV- 941

  Fly  1042 IFSTA---TAQIPESYGVEVMDHNNIEVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVT 1103
            :.|||   ...:|.....:|:.....|..|:......:.|.:..:.|  |::.||.||||||.::
Zfish   942 LHSTAHYEVMNVPSKIQPDVLPTGKAETHTKIIWRSPDGQEEVPLWW--IVVSIVAGLLLLAALS 1004

  Fly  1104 YVLWKVGFFKRIRP 1117
            .:.||:|||||.||
Zfish  1005 TIFWKMGFFKRNRP 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	18/62 (29%)
		Int_alpha	317..368	CDD:214549	19/57 (33%)
		Int_alpha	378..428	CDD:214549	26/51 (51%)
		Int_alpha	446..491	CDD:214549	20/45 (44%)
		Integrin_alpha2	479..1006	CDD:285619	121/554 (22%)
itga2b	NP_001003857.1	Int_alpha	256..>293	CDD:214549	14/37 (38%)
		Int_alpha	309..>358	CDD:214549	18/48 (38%)
		Int_alpha	376..429	CDD:214549	26/53 (49%)
		Int_alpha	441..>480	CDD:214549	19/38 (50%)
		Integrin_alpha2	475..908	CDD:285619	121/554 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574983
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750