Protein Alignment mew and itga3a

DIOPT Version :9

• Sequence 1: NP_001285196.1
• Gene: mew / 32275
• FlyBaseID: FBgn0004456
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: XP_017210291.1
• Gene: itga3a / 407685
• ZFINID: ZDB-GENE-090805-3
• Length: 1073
• Species: Danio rerio
• Alignment Length: 1190
• Identity: 315/1190 - (26%)
• Similarity: 508/1190 - (42%)
• Gaps: 269/1190 - (22%)

  Fly    19 LGILIILQCVLTCYNFNLEQRLPIVKYGH-PHSHFGYSVATH--TIGEANGPNKTNCVLVGAPLD 80
            |.::.:|.....|..|||:....:||.|. ..|.||.|||.|  .:.|     |.:.:|||||.:
Zfish    11 LTLVFVLSAARLCQAFNLDVSFAVVKEGKTAGSLFGLSVALHEQVVNE-----KRHMLLVGAPKE 70

  Fly    81 QNRQP-NTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIK----EDQWMGVTV- 139
            :.... :...:|.::.||::....||      .|.|..|.  :|....::|    :..|:||::
Zfish    71 KAESGLSANETGDVYACPISADSKDC------ARLNLISS--NPEDKPDLKNYVIDGMWLGVSIV 127

  Fly   140 -RSNPLQANGSGGKVIVCAHRYMYIVRENRYGQGLCYLLTNDL-------QFEEVHEPCKGRPVQ 196
             :|.|      ||:|:.|.|||:.....|....|.||:..|||       |::...|.|..|..|
Zfish   128 SQSQP------GGRVVACGHRYIRNFTSNFRMIGRCYVRGNDLQLNLSDYQWQSYDEICDPREAQ 186

  Fly   197 RQHEDYGLCQAGTSAALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSDLNSPV 261
            ...   |:|..|.|||:...: :..|:||.:.|:|:|:                    |..::|.
Zfish   187 NSE---GMCLLGMSAAVTFSE-IFFGAPGCFNWQGNIF--------------------SKWHNPA 227

  Fly   262 DKY----SYLGMSVTGGRFFGHM-------------SYAAGAPRSEGHGQVV---IFDKSTDNPI 306
            |::    |.|..|..|..:.|:.             :...||||.|..|.|:   :........:
Zfish   228 DEFHLLKSKLPDSRKGNIYIGYSTIVDQDVLVKGKDTVVTGAPRDEAKGSVMMAEVLKSGGSGEV 292

  Fly   307 PVHSILDGEQFGSSFGYELATADINGDHRPDLIVAAPLYFTK--TEGGAVYVYQNIQDTLPMKYT 369
            .:...:.|||.||.||..:|..|:|.|...||||.||.||.:  .:|||||||.|...:...|..
Zfish   293 KIKVTVTGEQVGSYFGNSVAVVDLNNDGWKDLIVGAPFYFDRKMDKGGAVYVYMNQNGSFRNKSD 357

  Fly   370 LKLTGPLESRFGLALANIGDLNKDNCEDLAVGAPYEGNGVVYIYLGSSQGLNSKPAQKIQASELG 434
            :.||||.:|.||:::..|||:|:|..:|.||||||...|.|.|:.||..|::.:|:|.|.    |
Zfish   358 VVLTGPKDSGFGMSVVAIGDVNQDGFQDFAVGAPYHSTGRVSIWTGSKTGISQEPSQVID----G 418

  Fly   435 GTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDP 499
            ..||.| ..:|||.|||...|:|.|.|||:.:|:.: ...|:|.:||:|.:      |....:.|
Zfish   419 KDIPGG-GFQTFGYSISRGLDVDRNGYPDIAVGSLD-DRVVLLRSRPVIHL------KNTFTVTP 475

  Fly   500 ---NTPGCLDDPASNLTCFTFRACCSIEPYD----EKNKELRLAYSVEAETFDHLKKFSRVFFFD 557
               |...|       :.|...:.|.|. .|.    ...|.:.|.|:|||:  ....:..||.|.|
Zfish   476 MVINLEDC-------VACIEAKVCFSY-TYSTGTASSQKAVTLQYTVEAD--QQSSRSPRVSFLD 530

  Fly   558 -RENKRTNVLSRVVRVHTNGRTECQAVTGYIKANT-RDIQTPVRFRLKYSLVEPPLADSALVR-- 618
             .:.|.|..:|    |:.:|  :|.::...:.:.| :|..:.:.|:|..|:|:||.:...::.
Zfish   531 NNKGKYTGKMS----VNPSG--DCHSLKLELASKTIQDKVSAIIFQLSVSVVDPPPSGGKMLEDL 589

  Fly   619 -LNPILDQTQA-------HVDFEGTFQKDCGDDDLCESNLII-------RVEPNITESSGNEYTL 668
             ..|::.|..|       |:      ||.||.|:.|||||.:       :..|.:.:.....:..
Zfish   590 SAFPVISQRDALTGRAEIHI------QKACGLDNKCESNLQMTAAFTDEKNTPFLMQEDHQIFNY 648

  Fly   669 ILDETELEVRINVSNL------ADSAYEAQLFIAHQAGVSYVATKKPTNATCN---SYNTTLVAC 724
            ..|..:|::.:||||:      |:.||.|.|.|...:.:|:.:......:|.|   |...:.:.|
Zfish   649 TTDIKKLKLLVNVSNVPSEGRKAEDAYNAILNITIPSSLSFSSLNPKLPSTLNGDPSSGGSYLLC 713

  Fly   725 SLGNPMLRDTTTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERPERDLR------------ 777
            :||:|...:....:.|.|:..|:....:.:...:..:|.|       .:.|||
Zfish   714 TLGDPFKSNQRVEIEITFETSGISIDMQEIETELQLSTLS-------DQNDLRPLSRVLLVEYIL 771

  Fly   778 ---VNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFN 839
               .|::...:..|.|..:.|.:..|.|.:.:.|....:.||.|. |:|               |
Zfish   772 QPLFNLIPYFRAEFSGNVVGESAMKSTSDIGSPVEFNISVDISGK-PLG---------------N 820

  Fly   840 EGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSR 904
            .|     .:::|..||.::.::       ::||||.::.....|:..| |||..||||||....|
Zfish   821 LG-----FLEVVFQWPSAVANE-------KWLLYLSEIQMTGTSESFC-VAKGIVNPLNLTVSER 872

  Fly   905 ENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRL 969
            :               |:.|          :|....|..:...|..|:..:|:.|.
Zfish   873 K---------------SRRR----------KRDEVLSESKLAMSQKTRQGQNKPRE--------- 903

  Fly   970 ERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNMPALSEAQVVVKARLWNSTLVSEY 1034
                                 .|:|.||...|....|.:..|.  :.|.:.|:||:||||::.:|
Zfish   904 ---------------------VLNCTKGTARCQTFSCPLSAMK--TSAMLTVRARVWNSTMLEDY 945

  Fly  1035 PRVERVRIFSTATAQIPESYGVEVMDHN----NIEVETRAYPELRNQQRDTSIPWLIIILGIVGG 1095
             |.:.|.:..:....:........|::|    .:|::.....||..:     .|..|||:.::.|
Zfish   946 -RAKGVSVQGSVMLTLKTDKKNIKMNNNIREFTVEIDPAVAEELPYE-----APLWIIIVSVLSG 1004

  Fly  1096 LLLLALVTYVLWKVGFFKRI 1115
            :::|.::..:|||.|||.||
Zfish  1005 VVMLGVIVILLWKSGFFTRI 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	19/65 (29%)
		Int_alpha	317..368	CDD:214549	24/52 (46%)
		Int_alpha	378..428	CDD:214549	23/49 (47%)
		Int_alpha	446..491	CDD:214549	17/44 (39%)
		Integrin_alpha2	479..1006	CDD:285619	124/576 (22%)
itga3a	XP_017210291.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574980
Domainoid	1	1.000	70	1.000	Domainoid score	I9498
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1884
OMA	1	1.010	-	-		QHG46425
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	1	1.000	-	-		FOG0001200
OrthoInspector	1	1.000	-	-		otm26039
orthoMCL	1	0.900	-	-		OOG6_102503
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X929
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770