DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and itga5

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001004288.2	Gene:	itga5 / 386787	ZFINID:	ZDB-GENE-031116-52	Length:	1053	Species:	Danio rerio

Alignment Length:	1171	Identity:	315/1171 - (26%)
Similarity:	498/1171 - (42%)	Gaps:	233/1171 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LGILIILQCVLTCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNR 83
            |.:||:|...:.   |||:...|.|..|...|:|||||..:.      .:.:..::||||.....
Zfish    21 LSLLILLPLSVA---FNLDVENPAVYNGPSGSYFGYSVDFYM------TDSSVSIIVGAPKANTS 76

  Fly    84 QPNTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQANG 148
            ||..|..|:::.||.:.....|..:..|...:.:..:.......|.|..||.|.|||.:.
Zfish    77 QPKITEGGSVFYCPWSLSQSQCSSIEFDRLGDLNMSVNDTDHQGEFKSHQWFGATVRVHQ----- 136

  Fly   149 SGGKVIVCAHRYMYIVRE---NRYGQGLCYL-LTNDLQFEEVHEPCKGRPVQRQHEDYGLCQAGT 209
              ..|:.||..|.:..:|   :....|.|:: :.|..:|.| :.||  |...|..:..|.||.|.
Zfish   137 --DSVLACAPLYSWRTKEDTPHADTTGSCFMSVKNFTKFVE-YAPC--RTEFRGRKGQGYCQGGF 196

  Fly   210 SAALLDDDTMVLGSPGPYTWRGSI----------------WVTQVGGEYLQRDKTTYYSDHSDLN 258
            ||....:..:|||.||.|.|:|.:                ::|.|||:...:.:.....|.
Zfish   197 SADFTQEGKVVLGGPGSYFWQGQVITAFKQEIVKAYYPGYFLTSVGGQIQTKQRKEIRFDD---- 257

  Fly   259 SPVDKYSYLGMSVTGGRFFG--HMSYAAGAPRS-EGHGQVVIFDKSTDNPIPVHSILDGEQFGSS 320
                  :|:|.||..|.|.|  ...:..|.||. ..||||.|.:.|.|    |..:..|||.||.
Zfish   258 ------TYMGYSVAVGEFTGDDDEDFVTGVPRGVRLHGQVSILNSSLD----VLKMFTGEQMGSY 312

  Fly   321 FGYELATADINGDHRPDLIVAAPLYFTK------TEGGAVYVY--QNIQDTLPMKYTLKLTG-PL 376
            :||.:|..|||.|...||:|.||::..:      .|.|.||||  :...|.:|.  ...||| .:
Zfish   313 YGYSVAATDINNDGMMDLLVGAPMFMVRDSDGRLEELGRVYVYMQKGPLDLIPQ--LPHLTGTQM 375

  Fly   377 ESRFGLALANIGDLNKDNCEDLAVGAPYEG---NGVVYIYLGSSQGLNSKPAQKIQ---ASELGG 435
            .:|||.::..:||||:|...|:|:.:|:.|   .|:|.||.|::.||..||:|.|.   ||....
Zfish   376 FARFGSSITPLGDLNQDGYNDVAISSPFGGEDKQGLVLIYNGNAGGLREKPSQVISGQWASAGLS 440

  Fly   436 TIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPN 500
            .||     .:||.::.|..|||:|.|||:::|||.:..||:..:|||::....:....: .::|.
Zfish   441 AIP-----ASFGYALRGGKDLDNNGYPDLIVGAFGADKAVLYRSRPIVNTSAILNVYPI-MINPE 499

  Fly   501 TPGCL---DDPASNLTCFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKK-----FSRVFFFD 557
            ...|.   .:...:::|.....|.|.   :.|:....|.::||.: .|.||:     ..|..|.:
Zfish   500 EKVCAISRGNETLHVSCVNLSFCLSA---NGKHLPNHLEFNVEVQ-LDRLKQQQKGAVRRALFLE 560

  Fly   558 RENKRTNVLSRVVRVHTNGRTECQAVTGYIK--ANTRDIQTPVRFRLKYSLVEPPLADSALVRLN 620
            .:   ...|.|.:.| .||...|.....|::  .:.||..:|:...|.:||.....||..  .|.
Zfish   561 TQ---LPALHRTLTV-PNGARVCSDTKIYLRDEKDFRDKLSPIFVALNFSLNPQAAADRH--GLQ 619

  Fly   621 PILD-QTQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRINVSNL 684
            |||: ||...::.:.....|||:|::|..:|.:.|..:..|      ..:.|:..|.:..|..|.
Zfish   620 PILNYQTAELIEQKAQILLDCGEDNICVPDLKLSVHGDRKE------VYMGDDNSLTLTFNAKND 678

  Fly   685 ADSAYEAQLFIA--HQAGVSYVA--TKKPTNATCNSY----NTTLVACSLGNPMLRDTTTFVTIR 741
            ...||||:|::.  .:|..|.:|  .:..|..|| ||    .|..::|.|||||...|:.:..:|
Zfish   679 GGGAYEAELYVVLPPEADYSGIARNNESLTQLTC-SYETENQTRYLSCDLGNPMKSGTSLWAGLR 742

  Fly   742 FQPKGLEPSEKIMLFHIFA------NTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFYS 800
            |....|:.:...:.|.:..      |:.|::|       ..::.||.|:.:..:|.:.|::.|:.
Zfish   743 FTVPRLKDTHNFVQFDLQIRSKNENNSQSEVV-------PYKLEVVVRSDVILQGVSRPDKVFFP 800

  Fly   801 GSS--VANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQ 863
            ..:  :..:|             |...:||..|.|.:.:.|.|||......:.:..|..|:|:
Zfish   801 PPNWKLTKNV-------------MVEQNVGPSVQHTYELVNNGPSRISHTLLQLKCPMRLHSN-- 850

  Fly   864 SGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLN--LASGSRENPAYLSAPAQMRMFPSQSRHS 926
                 :::..||......|:   | .....:||||  |...|.|.|     |.:    .|...|.
Zfish   851 -----RFIYPLEVTTEGPVN---C-TTHNIINPLNLKLQQSSTEQP-----PVR----DSGHEHH 897

  Fly   927 FNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVE 991
            ..|              ||.|                                   .|:...:..
Zfish   898 IEK--------------RDTH-----------------------------------KGELSQLTN 913

  Fly   992 LDCNKGATNCVRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGV 1056
            |.|:  :.:|..:.|::..:...:.|.:.|::|:|..|.:.        ..:.....:...||.|
Zfish   914 LSCS--SVDCWTLMCNVGLLERGTSAILHVRSRIWAETFME--------NTYKNFILECHASYKV 968

  Fly  1057 EVMDHNNIEVET------RAYPELRNQQRDTS--IPWLIIILGIVGGLLLLALVTYVLWKVGFFK 1113
            |.|.:..:...|      ...|.:.|:. |:|  :|..||||.|:.|||||||:.|||:|:||||
Zfish   969 EKMPYAILPKVTPSGSKKMVTPVVWNKP-DSSYAVPLWIIILAILAGLLLLALLIYVLYKLGFFK 1032

  Fly  1114 R 1114
            |
Zfish  1033 R 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	17/62 (27%)
		Int_alpha	317..368	CDD:214549	22/58 (38%)
		Int_alpha	378..428	CDD:214549	22/52 (42%)
		Int_alpha	446..491	CDD:214549	18/44 (41%)
		Integrin_alpha2	479..1006	CDD:285619	120/555 (22%)
itga5	NP_001004288.2	Int_alpha	47..104	CDD:214549	17/62 (27%)
		VCBS	269..332	CDD:290251	27/66 (41%)
		Int_alpha	309..>357	CDD:214549	20/47 (43%)
		Int_alpha	375..430	CDD:214549	22/54 (41%)
		Int_alpha	446..>484	CDD:214549	18/37 (49%)
		Integrin_alpha2	479..926	CDD:285619	120/555 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820