DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itgad

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001025043.3	Gene:	Itgad / 381924	MGIID:	3578624	Length:	1202	Species:	Mus musculus

Alignment Length:	1033	Identity:	245/1033 - (23%)
Similarity:	384/1033 - (37%)	Gaps:	316/1033 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 QHEDYGLCQAGTSAALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYS---DHSDLNS 259
            |||   :.|.|.|:| |..|..|||:.|.::|.|..::      |....::|:.:   ::.|:..
Mouse   390 QHE---MSQEGFSSA-LSMDGPVLGAVGSFSWSGGAFL------YPSNMRSTFINMSQENEDMRD 444

  Fly   260 PVDKYSYLGMSVTGGRFFGHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYE 324
                 :|||.|.....:.|..|...||||.:..|:||||.:.:.:..| .|.:.|.|.||.||..
Mouse   445 -----AYLGYSTALAFWKGVHSLILGAPRHQHTGKVVIFTQESRHWRP-KSEVRGTQIGSYFGAS 503

  Fly   325 LATADINGDHRPDLI-VAAPLYFTKTEGGAVYVYQNIQDTLPM-----KYTLKLT-----GPLES 378
            |.:.|::.|...||: :..|.|:..|.||.|.|       .||     ::....|     |....
Mouse   504 LCSVDMDRDGSTDLVLIGVPHYYEHTRGGQVSV-------CPMPGVRSRWHCGTTLHGEQGHPWG 561

  Fly   379 RFGLALANIGDLNKDNCEDLAVGAP--YEGNGVVYIYLGSS-QGLNSKPAQKIQASELGGTIPNG 440
            |||.||..:||:|.|:..|:|:|||  .|..|.|||:.|:| |.:...|:|::..|:|      .
Mouse   562 RFGAALTVLGDVNGDSLADVAIGAPGEEENRGAVYIFHGASRQDIAPSPSQRVTGSQL------F 620

  Fly   441 QPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQ------RKELHNMDP 499
            ..::.||.|:||..||..:...|:.:||  ....::|.:.|::.:..|::      .|.::....
Mouse   621 LRLQYFGQSLSGGQDLTQDGLVDLAVGA--QGHVLLLRSLPLLKVGISIRFAPSEVAKTVYQCWG 683

  Fly   500 NTPGCLDDPASNLT-CFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKKFSRVFFFDRENKRT 563
            .||..|:  |...| |.|.|. .|.:...:....:|  |.:   ..|..:..||..|.:.:|
Mouse   684 RTPTVLE--AGEATVCLTVRK-GSPDLLGDVQSSVR--YDL---ALDPGRLISRAIFDETKN--- 737

  Fly   564 NVLSRVVRVHTNGRTE-CQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSALVR-LNPILD-Q 625
               ..:.|..|.|..: |:.:...:.....|..||:..||..||.    .|||..| |.|:|. .
Mouse   738 ---CTLTRRKTLGLGDHCETMKLLLPDCVEDAVTPIILRLNLSLA----GDSAPSRNLRPVLAVG 795

  Fly   626 TQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRINVSNLADSAYE 690
            :|.||.....|:|:|..:.|||.||.:..     ..||.:...:....||.|.:.|.|..:.:|.
Mouse   796 SQDHVTASFPFEKNCKQELLCEGNLGVSF-----NFSGLQVLEVGSSPELTVTVTVWNEGEDSYG 855

  Fly   691 AQLFIAHQAGVSYVATKK-------PTNATCNSYNT-----TLVACSLGNPMLRD--TTTFVTIR 741
            ..:...:.|.:||....:       |....|.:..|     ...:||:.:|:.|:  ..||:
Mouse   856 TLIKFYYPAELSYRRVTRAQQPHPYPLRLACEAEPTGQESLRSSSCSINHPIFREGAKATFM--- 917

  Fly   742 FQPKGLEPSEKIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVAN 806
                                              :..:|..:|.|..|
Mouse   918 ----------------------------------ITFDVSYKAFLGDR----------------- 931

  Fly   807 SVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYL 871
             :...|:...|.:.|                  |...||.::::                ||:|.
Mouse   932 -LLLRASASSENNKP------------------ETSKTAFQLEL----------------PVKYT 961

  Fly   872 LYLEQVPTV-------------EVSQGECHVAKEY------VNPLNLA-----------SGSREN 906
            :|     ||             ..|.||.....|:      ::||.||           :|....
Mouse   962 VY-----TVISRQEDSTKHFNFSSSHGERQKEAEHRYRVNNLSPLTLAISVNFWVPILLNGVAVW 1021

  Fly   907 PAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLER 971
            ...|.:|||                   ..|..|......|||               .:|:::
Mouse  1022 DVTLRSPAQ-------------------GVSCVSQREPPQHSD---------------LLTQIQ- 1051

  Fly   972 LMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNMPALSEAQVVVKARL---WNSTLVSE 1033
                        |:.    .|||  ...:|:.:.|||.::..|.|...::|..|   |.|..:.
Mouse  1052 ------------GRS----VLDC--AIADCLHLRCDIPSLGTLDELDFILKGNLSFGWISQTLQ- 1097

  Fly  1034 YPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYPELRNQ------QRDTSI-------PW 1085
                ::|.:.|.|                .|...|..|.:|..|      |..|.:       |.
Mouse  1098 ----KKVLLLSEA----------------EITFNTSVYSQLPGQEAFLRAQVSTMLEEYVVYEPV 1142

  Fly  1086 LIIILGIVGGLLLLALVTYVLWKVGFFKR-------IRPTDPTLSGNLEKMNEEKPFL 1136
            .:::...|||||||||:|..|:|:|||||       :...||..:|..:..:|..|.|
Mouse  1143 FLMVFSSVGGLLLLALITVALYKLGFFKRQYKEMLDLPSADPDPAGQADSNHETPPHL 1200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549
		Int_alpha	317..368	CDD:214549	18/56 (32%)
		Int_alpha	378..428	CDD:214549	24/52 (46%)
		Int_alpha	446..491	CDD:214549	13/50 (26%)
		Integrin_alpha2	479..1006	CDD:285619	108/580 (19%)
Itgad	NP_001025043.3	vWA_integrins_alpha_subunit	156..367	CDD:238746
		Int_alpha	496..546	CDD:214549	18/56 (32%)
		Int_alpha	559..614	CDD:214549	24/54 (44%)
		Int_alpha	624..>648	CDD:214549	8/23 (35%)
		Integrin_alpha2	666..>1003	CDD:285619	89/453 (20%)
		Integrin_alpha	1165..1178	CDD:278771	6/12 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740