DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mew and ITGAX

DIOPT Version :9

Sequence 1:NP_001285196.1 Gene:mew / 32275 FlyBaseID:FBgn0004456 Length:1243 Species:Drosophila melanogaster
Sequence 2:NP_001273304.1 Gene:ITGAX / 3687 HGNCID:6152 Length:1169 Species:Homo sapiens


Alignment Length:1141 Identity:264/1141 - (23%)
Similarity:421/1141 - (36%) Gaps:348/1141 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   108 VITDGRRNFDS----EILSPPGNDEIKEDQWMGVTVRSNPLQANGSGGKVIVCAHRYMYIVRENR 168
            |||||::..||    :::                     |: |:.:|            |:   |
Human   256 VITDGKKEGDSLDYKDVI---------------------PM-ADAAG------------II---R 283

  Fly   169 YGQGLCYLLTNDLQFEEVHEPCKGRPVQRQH----EDYG-------------------------- 203
            |..|:.....|...::|::: ...:|.| :|    ||:.                          
Human   284 YAIGVGLAFQNRNSWKELND-IASKPSQ-EHIFKVEDFDALKDIQNQLKEKIFAIEGTETTSSSS 346

  Fly   204 ----LCQAGTSAALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYS---DHSDLNSPV 261
                :.|.|.||....|.. |||:.|.:||.|..::      |......|:.:   ::.|:..  
Human   347 FELEMAQEGFSAVFTPDGP-VLGAVGSFTWSGGAFL------YPPNMSPTFINMSQENVDMRD-- 402

  Fly   262 DKYSYLGMSVTGGRFFGHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELA 326
               ||||.|.....:.|..|...||||.:..|:.|||.: ......:.:.:.|.|.||.||..|.
Human   403 ---SYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQ-VSRQWRMKAEVTGTQIGSYFGASLC 463

  Fly   327 TADINGDHRPDLI-VAAPLYFTKTEGGAVYVYQNIQDTLPMKY--------TLKLTGPLESRFGL 382
            :.|::.|...||: :.||.|:.:|.||.|.|.     .||..:        .....|....|||.
Human   464 SVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVC-----PLPRGWRRWWCDAVLYGEQGHPWGRFGA 523

  Fly   383 ALANIGDLNKDNCEDLAVGAP--YEGNGVVYIY---LGSSQGLNSKPAQKIQASELGGTIPNGQP 442
            ||..:||:|.|...|:.:|||  .|..|.||::   ||.|  ::...:|:|..|:|...      
Human   524 ALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPS--ISPSHSQRIAGSQLSSR------ 580

  Fly   443 IRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQ-------RKELHNMDPN 500
            ::.||.::||..||..:...|:.:||  ....::|..||::.:..|:|       |....     
Human   581 LQYFGQALSGGQDLTQDGLVDLAVGA--RGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFE----- 638

  Fly   501 TPGCLDDPASNLTCFTFRACCSIEPYDEKNKEL----RLAYSVEAE-TFDHLKKFSRVFFFDREN 560
               |.:...|..|......|..|   |:::|.|    .|..||..: ..|..:...|..|.:.:|
Human   639 ---CREQVVSEQTLVQSNICLYI---DKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKN 697

  Fly   561 KRTNVLSRV----VRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSALVRLNP 621
            :.   ||||    ::.|      |:.....:.:...|..||:..||.::||..||.  |...|.|
Human   698 RS---LSRVRVLGLKAH------CENFNLLLPSCVEDSVTPITLRLNFTLVGKPLL--AFRNLRP 751

  Fly   622 IL-DQTQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRINVSNLA 685
            :| ...|.:......|:|:||.|.:|:.||.|..     ...|.:..|:....||...:.|.|..
Human   752 MLAADAQRYFTASLPFEKNCGADHICQDNLGISF-----SFPGLKSLLVGSNLELNAEVMVWNDG 811

  Fly   686 DSAYEAQLFIAHQAGVS--YVA------TKKPTNATCN-----SYNTTLVACSLGNPMLR---DT 734
            :.:|...:..:|.||:|  |||      ..:..:.||:     |..|...:|.:.:.:.|   ..
Human   812 EDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQI 876

  Fly   735 TTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFY 799
            |...|....||.: ..::::|   .||.:|:            .|..|.:|..|: ..:|.:  |
Human   877 TFLATFDVSPKAV-LGDRLLL---TANVSSE------------NNTPRTSKTTFQ-LELPVK--Y 922

  Fly   800 SGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQS 864
            :..:|.:|                        |..||                            
Human   923 AVYTVVSS------------------------HEQFT---------------------------- 935

  Fly   865 GRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLS--APAQMRMFPSQSRHSF 927
                :||.:.|.      .:.|.|||.......||  |.|:.|..::  .|.::    :|.....
Human   936 ----KYLNFSES------EEKESHVAMHRYQVNNL--GQRDLPVSINFWVPVEL----NQEAVWM 984

  Fly   928 NKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVEL 992
            :..:.|.|                    |...|...|::.       .|.|...|:.:|..:  |
Human   985 DVEVSHPQ--------------------NPSLRCSSEKIA-------PPASDFLAHIQKNPV--L 1020

  Fly   993 DCNKGATNCVRIECDILNMPALSEAQVVVKARL---WNSTLVSEYPRVERVRIFSTATAQIPESY 1054
            ||:  ...|:|..||:.:.....|....:|..|   |...::.     ::|.:.|.|        
Human  1021 DCS--IAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQ-----KKVSVVSVA-------- 1070

  Fly  1055 GVEVMDHNNIEVETRAYPELRNQQ-----RDTSI--------PWLIIILGIVGGLLLLALVTYVL 1106
                    .|..:|..|.:|..|:     :.|::        |..:|:...:||||||||:|.||
Human  1071 --------EITFDTSVYSQLPGQEAFMRAQTTTVLEKYKVHNPTPLIVGSSIGGLLLLALITAVL 1127

  Fly  1107 WKVGFFKRIRPTDPTLSGNLEKMNEEKPFLAPSKNT 1142
            :|||||||         ...|.|.|....:||...|
Human  1128 YKVGFFKR---------QYKEMMEEANGQIAPENGT 1154

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mewNP_001285196.1 Int_alpha 48..111 CDD:214549 2/2 (100%)
Int_alpha 317..368 CDD:214549 19/51 (37%)
Int_alpha 378..428 CDD:214549 21/54 (39%)
Int_alpha 446..491 CDD:214549 14/51 (27%)
Integrin_alpha2 479..1006 CDD:285619 116/561 (21%)
ITGAXNP_001273304.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 23..78
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 79..138
vWA_integrins_alpha_subunit 150..325 CDD:238746 21/107 (20%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 340..391 14/57 (25%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 392..443 16/56 (29%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 444..504 21/64 (33%)
Int_alpha 454..504 CDD:214549 19/54 (35%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 507..565 21/59 (36%)
Int_alpha 517..>558 CDD:214549 17/40 (43%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 570..630 18/67 (27%)
Int_alpha 582..628 CDD:214549 14/47 (30%)
Integrin_alpha2 615..1032 CDD:285619 116/561 (21%)
Integrin_alpha 1129..1143 CDD:278771 9/22 (41%)
GFFKR motif 1131..1135 3/3 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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