DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and ITGAV

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_002201.2	Gene:	ITGAV / 3685	HGNCID:	6150	Length:	1048	Species:	Homo sapiens

Alignment Length:	1190	Identity:	307/1190 - (25%)
Similarity:	507/1190 - (42%)	Gaps:	212/1190 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PNCRLRQN-LGILIILQCVL--TCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTN- 71
            |..|||.. .|:.::|..:|  .|..|||:...|....|...|:||::|....      |:.::
Human     5 PRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFV------PSASSR 63

  Fly    72 -CVLVGAPLDQNRQPNTTHSGALWRC--PMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQ 133
             .:|||||.....||.....|.:.:|  ..|:|   |:.:..|...|.|.....|.   |.|..|
Human    64 MFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRR---CQPIEFDATGNRDYAKDDPL---EFKSHQ 122

  Fly   134 WMGVTVRSNPLQANGSGGKVIVCAHRYMY--IVRENRYGQGLCYLLTNDLQFEEVHEPCKGRPVQ 196
            |.|.:|||..       .|::.||..|.:  .:::.|...|.|:|.......|  :.||:.:.:.
Human   123 WFGASVRSKQ-------DKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVE--YAPCRSQDID 178

  Fly   197 RQHEDYGLCQAGTSAALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSD----- 256
            .  :..|.||.|.|......|.::||.||.:.|:|.:...||.....:.|...|...:::
Human   179 A--DGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATR 241

  Fly   257 LNSPVDKYSYLGMSVTGGRFFGH--MSYAAGAPR-SEGHGQVVIFDKSTDNPIPVHSILDGEQFG 318
            ....:...||||.||..|.|.|.  ..:.:|.|| :...|.|.|:|..  |...::: ..|||..
Human   242 TAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGK--NMSSLYN-FTGEQMA 303

  Fly   319 SSFGYELATADINGDHRPDLIVAAPLYFTKTEGGAVYVYQNIQDTLPMK----YTLKLTG-PLES 378
            :.||:.:|..|||||...|:.:.|||:..:...|.:.....:..:|...    .|.||.| .:.:
Human   304 AYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFA 368

  Fly   379 RFGLALANIGDLNKDNCEDLAVGAPYEG---NGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNG 440
            |||.|:|.:|||::|...|:|:.|||.|   .|:|||:.|.|.|||:.|:|.::......::|
Human   369 RFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMP-- 431

  Fly   441 QPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQ-RKELHNMDPNTPGC 504
               .:||.|:.|.||:|.|.|||:::|||....|::..|||:|::...:: ...:.|.|..|  |
Human   432 ---PSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKT--C 491

  Fly   505 -LDDPASNLTCFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKKFSRV----FFFDRENKRTN 564
             |...|..::||..|.|...:......::|.  :.||. ..|.||:...:    |.:.|....
Human   492 SLPGTALKVSCFNVRFCLKADGKGVLPRKLN--FQVEL-LLDKLKQKGAIRRALFLYSRSPSH-- 551

  Fly   565 VLSRVVRVHTNGRTECQAVTGYIK--ANTRDIQTPVRFRLKYSLVEPPLADSALVRLNPILDQ-T 626
              |:.:.:...|..:|:.:..|::  :..||..||:...::|.|.....||:  ..|.|||:| |
Human   552 --SKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADT--TGLQPILNQFT 612

  Fly   627 QAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRINVSNLADSAYEA 691
            .|::..:.....|||:|::|:..|.:.|:      |..:...|.|:..|.:.:...|..:.||||
Human   613 PANISRQAHILLDCGEDNVCKPKLEVSVD------SDQKKIYIGDDNPLTLIVKAQNQGEGAYEA 671

  Fly   692 QLFIAHQAGVSYVATKKPTNA----TC---NSYNTTLVACSLGNPMLRDTTTFVTIRF---QPKG 746
            :|.::......::...:...|    :|   ....|..|.|.|||||...|.....:||   |...
Human   672 ELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSE 736

  Fly   747 LEPSEKIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANT 811
            ::.|.|..|    ...:|.|.....|....:|::...|.:..||.:.|:..|.       .:.|.
Human   737 MDTSVKFDL----QIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFL-------PIPNW 790

  Fly   812 AATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQ 876
            ...:    .|...:|||..|.|::.:.|.|||:..|..:.:.|||...::.        |||:
Human   791 EHKE----NPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNT--------LLYI-- 841

  Fly   877 VPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSS 941
                        :..:...|:|..|....||..:..                            |
Human   842 ------------LHYDIDGPMNCTSDMEINPLRIKI----------------------------S 866

  Fly   942 SHRDDHSDDT---QSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVR 1003
            |.:....:||   |..|:.:       :|:.:..:           .:.||..|.|  |...|::
Human   867 SLQTTEKNDTVAGQGERDHL-------ITKRDLAL-----------SEGDIHTLGC--GVAQCLK 911

  Fly  1004 IECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVET 1068
            |.|.:..:.....|.:.||:.||..|.:::..:.....:.|:|      |:.|....:.|:.:|
Human   912 IVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSA------SFNVIEFPYKNLPIE- 969

  Fly  1069 RAYPELRN------------QQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPT 1121
                ::.|            |.....:|..:|||.::.||||||::.:|::::|||||:||
Human   970 ----DITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRP---- 1026

  Fly  1122 LSGNLEKMNEEKPFLAPSKN 1141
                 .:..:|:..|.|.:|
Human  1027 -----PQEEQEREQLQPHEN 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	17/66 (26%)
		Int_alpha	317..368	CDD:214549	14/54 (26%)
		Int_alpha	378..428	CDD:214549	26/52 (50%)
		Int_alpha	446..491	CDD:214549	19/45 (42%)
		Integrin_alpha2	479..1006	CDD:285619	121/548 (22%)
ITGAV	NP_002201.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	32..98		20/74 (27%)
		Int_alpha	46..103	CDD:214549	17/65 (26%)
		WD40 repeat	51..120	CDD:293791	19/80 (24%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	109..170		19/72 (26%)
		WD40 repeat	126..183	CDD:293791	14/67 (21%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	173..225		14/53 (26%)
		WD40 repeat	188..248	CDD:293791	13/59 (22%)
		VCBS	221..271	CDD:316075	11/49 (22%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	237..291		16/55 (29%)
		Int_alpha	248..>288	CDD:214549	15/39 (38%)
		WD40 repeat	254..298	CDD:293791	13/46 (28%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	292..357		17/65 (26%)
		Int_alpha	302..355	CDD:214549	14/52 (27%)
		WD40 repeat	307..362	CDD:293791	15/54 (28%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	358..415		27/56 (48%)
		Int_alpha	367..421	CDD:214549	26/53 (49%)
		WD40 repeat	371..422	CDD:293791	24/50 (48%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	419..482		21/67 (31%)
		Int_alpha	434..476	CDD:214549	19/41 (46%)
		Integrin_alpha2	467..914	CDD:312071	121/548 (22%)
		GFFKR motif	1019..1023		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1027..1048		4/15 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141979
Domainoid	1	1.000	54	1.000	Domainoid score	I11211
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750