DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and ITGAM

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001139280.1	Gene:	ITGAM / 3684	HGNCID:	6149	Length:	1153	Species:	Homo sapiens

Alignment Length:	989	Identity:	234/989 - (23%)
Similarity:	381/989 - (38%)	Gaps:	271/989 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 QHEDYGLCQAGTSAALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYS---DHSDLNS 259
            :||   :.|.|.|||:..:..: |.:.|.|.|.|.:::      |..::|:|:.:   ..||:|.
Human   347 EHE---MSQEGFSAAITSNGPL-LSTVGSYDWAGGVFL------YTSKEKSTFINMTRVDSDMND 401

  Fly   260 PVDKYSYLGMS---VTGGRFFGHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSF 321
                 :|||.:   :...|.   .|...||||.:..|.|.:|.::| .....::.:.|.|.|:.|
Human   402 -----AYLGYAAAIILRNRV---QSLVLGAPRYQHIGLVAMFRQNT-GMWESNANVKGTQIGAYF 457

  Fly   322 GYELATADINGDHRPDLI-VAAPLYFTKTEGGAVYVYQNIQDTLPMKYTLKL---------TGPL 376
            |..|.:.|::.:...||: :.||.|:.:|.||.|.|.     .||.....:.         .|..
Human   458 GASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVC-----PLPRGQRARWQCDAVLYGEQGQP 517

  Fly   377 ESRFGLALANIGDLNKDNCEDLAVGAPYE--GNGVVYIYLGSS-QGLNSKPAQKIQASELGGTIP 438
            ..|||.||..:||:|.|...|:|:|||.|  ..|.||::.|:| .|::...:|:|..|:|.   |
Human   518 WGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLS---P 579

  Fly   439 NGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDP---- 499
            .   ::.||.|:||..||..:...|:.:||  ....::|.::|::.:      |.:...:|
Human   580 R---LQYFGQSLSGGQDLTMDGLVDLTVGA--QGHVLLLRSQPVLRV------KAIMEFNPREVA 633

  Fly   500 -NTPGCLDDPASNLTCFTFRACCSIEPYDEKNKELRLAYSVEAETFDHL----KKFSRVFFFDRE 559
             |...|.|...........|.|..::  ......||........|:|..    :..||..|.:.:
Human   634 RNVFECNDQVVKGKEAGEVRVCLHVQ--KSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETK 696

  Fly   560 N---KRTNVLSRVVRVHTNGRTE-CQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSALVRLN 620
            |   ::|.||         |.|: |:.:...:.....|..:|:..||.:|||..||  ||...|.
Human   697 NSTRRQTQVL---------GLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVGTPL--SAFGNLR 750

  Fly   621 PIL-DQTQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLIL-DETELEVRINVSN 683
            |:| :..|........|:|:||:|::|:.:|      :||.|..:...|:: ...|..|.:.|.|
Human   751 PVLAEDAQRLFTALFPFEKNCGNDNICQDDL------SITFSFMSLDCLVVGGPREFNVTVTVRN 809

  Fly   684 LADSAYEAQLFIAHQAGVSY--VAT------KKPTNATCNSYNTTLV-------ACSLGNPMLRD 733
            ..:.:|..|:.......:||  |:|      ::.....|.|.::|.|       :||:.:|:..:
Human   810 DGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWRLACESASSTEVSGALKSTSCSINHPIFPE 874

  Fly   734 TT--TF-VTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPE 795
            .:  || :|.....|. ....|::|   .||.||:            .|:.|..|..|:.....:
Human   875 NSEVTFNITFDVDSKA-SLGNKLLL---KANVTSE------------NNMPRTNKTEFQLELPVK 923

  Fly   796 QSFY---SGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYS 857
            .:.|   :...|:....|..|:          ::....:.|.:.:.|.|..:.| :.:|...|..
Human   924 YAVYMVVTSHGVSTKYLNFTAS----------ENTSRVMQHQYQVSNLGQRSLP-ISLVFLVPVR 977

  Fly   858 LYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQ 922
            |.......||        ||...|.....||..:.                          .||
Human   978 LNQTVIWDRP--------QVTFSENLSSTCHTKER--------------------------LPS- 1007

  Fly   923 SRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQ 987
                                    |||            ||                  |..:|.
Human  1008 ------------------------HSD------------FL------------------AELRKA 1018

  Fly   988 DIVELDCNKGATNCVRIECDILNMPALSEAQVVVKARL---WNSTLVSEYPRVERVRIFSTATAQ 1049
            .:|    |.....|.||:|||.......|....:|..|   |       |.:.....:...:||
Human  1019 PVV----NCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDW-------YIKTSHNHLLIVSTA- 1071

  Fly  1050 IPESYGVEVMDHNNI-------------EVETRAYP-ELRNQQRDTSIPWLIIILGIVGGLLLLA 1100
                   |::.::::             :.||:..| |:.|       |..:|:...||||||||
Human  1072 -------EILFNDSVFTLLPGQGAFVRSQTETKVEPFEVPN-------PLPLIVGSSVGGLLLLA 1122

  Fly  1101 LVTYVLWKVGFFKR 1114
            |:|..|:|:|||||
Human  1123 LITAALYKLGFFKR 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549
		Int_alpha	317..368	CDD:214549	17/51 (33%)
		Int_alpha	378..428	CDD:214549	22/52 (42%)
		Int_alpha	446..491	CDD:214549	12/44 (27%)
		Integrin_alpha2	479..1006	CDD:285619	111/562 (20%)
ITGAM	NP_001139280.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	18..75
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	76..135
		vWA_integrins_alpha_subunit	149..324	CDD:238746
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	339..390		15/52 (29%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	391..442		16/59 (27%)
		Int_alpha	453..>495	CDD:214549	15/46 (33%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	507..565		22/57 (39%)
		Int_alpha	517..563	CDD:214549	20/45 (44%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	570..630		18/73 (25%)
		Integrin_alpha2	615..979	CDD:285619	89/415 (21%)
		Integrin_alpha	1130..1144	CDD:278771	6/7 (86%)
		GFFKR motif	1132..1136		3/3 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142041
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740