DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and ITGAL

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_002200.2	Gene:	ITGAL / 3683	HGNCID:	6148	Length:	1170	Species:	Homo sapiens

Alignment Length:	1352	Identity:	281/1352 - (20%)
Similarity:	471/1352 - (34%)	Gaps:	506/1352 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NFNLEQRLPIVKYGHPHS--HFGYSVATHTIGEANGPNKTNCVLVGAPLDQNRQPNTTHSGALWR 95
            ::||:.| ....:..|.:  ||||.|.  .:|        |.|:||||.:.|      .:|:|::
Human    25 SYNLDVR-GARSFSPPRAGRHFGYRVL--QVG--------NGVIVGAPGEGN------STGSLYQ 72

  Fly    96 C--------PMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQANGSGGK 152
            |        |:|.|           ..|:.|              :::|:|:.::|     :.|.
Human    73 CQSGTGHCLPVTLR-----------GSNYTS--------------KYLGMTLATDP-----TDGS 107

  Fly   153 VIVCAHRYMYIVRENRYGQGLCYLLTNDLQFEEVHEPCKGRP----------------------- 194
            ::.|.........:|.|..|||||...:||...:    :|||
Human   108 ILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPML----QGRPGFQECIKGNVDLVFLFDGSMSLQ 168

  Fly   195 -------------------------------------------VQR-------QHEDYGLCQAGT 209
                                                       |:|       :|..:.|....|
Human   169 PDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNT 233

  Fly   210 SAAL--------------LDDDT--MVLGSPGPYTWRGSI--------WVTQVGGEYLQRD--KT 248
            ..|:              ..|.|  :::.:.|..|..|:|        ::..:|..:..::  :|
Human   234 FGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQET 298

  Fly   249 TY----------------YSDHSDLNSPVDKYSYL---------------------------GMS 270
            .:                :....||.:.:.|..|:                           |.:
Human   299 LHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHA 363

  Fly   271 VTG--------GRFF-----------------------GHMSY--------------AAGAPRSE 290
            |.|        |.|.                       |::.|              |:||||.:
Human   364 VVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQ 428

  Fly   291 GHGQVVIFDKSTDNPIPVH----SILDGEQFGSSFGYELATADINGDHRPD-LIVAAPLYFTKTE 350
            ..|:|::|.:.....   |    ..:.|.|.||.||.||...|::.|...: |::.|||::.:..
Human   429 HMGRVLLFQEPQGGG---HWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQR 490

  Fly   351 GGAVYVYQNIQDTLPMKYTLKLTG----PLESRFGLALANIGDLNKDNCEDLAVGAPYEGNGVVY 411
            ||.|::||..|  |..:...:|.|    || .|||.|:..:.|:|.|...|:|||||.|..|.||
Human   491 GGRVFIYQRRQ--LGFEEVSELQGDPGYPL-GRFGEAITALTDINGDGLVDVAVGAPLEEQGAVY 552

  Fly   412 IYLGSSQGLNSKPAQKIQASE-LGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAV 475
            |:.|...||:.:|:|:|:.:: |.|       |:.||.||.|..||:.:...||.:||  .|..:
Human   553 IFNGRHGGLSPQPSQRIEGTQVLSG-------IQWFGRSIHGVKDLEGDGLADVAVGA--ESQMI 608

  Fly   476 ILLARPIISIQT----SVQRKELHNMD--PNTPGCLDDPASNLTCFTFRACCSIEPYDEKNKELR 534
            :|.:||::.:.|    |.....:|.::  .:|...:.:..:...||..:   |:.|..:......
Human   609 VLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIK---SLIPQFQGRLVAN 670

  Fly   535 LAYSVEAETFDHLKKFSRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANTRDIQTPVR 599
            |.|:::.:  .|..:...:|...|...|.|     :.|.|:  ..|...:.:.....:|:.:|:.
Human   671 LTYTLQLD--GHRTRRRGLFPGGRHELRRN-----IAVTTS--MSCTDFSFHFPVCVQDLISPIN 726

  Fly   600 FRLKYSLVE---PPLADSALVR-LNPILDQTQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITE 660
            ..|.:||.|   .|....|..: :.|||..:.....:|..|:|:||:|..||:||.:...|  ..
Human   727 VSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSP--AR 789

  Fly   661 SSGNEYTLILDETELEVRINVSNLADSAYEAQLFIAHQAGVSY--VATKKPTN---ATCNSYN-- 718
            |.....|..   ..|.|.:::|||.:.||..||.:....|:|:  |...||.:   .:|....
Human   790 SRALRLTAF---ASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEE 851

  Fly   719 ----TTLVACSLGNPMLRDTTTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERPERDLRVN 779
                :..::|::.:|:.:   ...::..|          |:|:...|::
Human   852 SRLLSRALSCNVSSPIFK---AGHSVALQ----------MMFNTLVNSS---------------- 887

  Fly   780 VVRRAKLNFRGWAIPEQSFYSGSSV---ANSVANTAATD-IEGHG---------PMGM---DDVG 828
                       |         |.||   ||...|...:| :|.:.         |:.:   |...
Human   888 -----------W---------GDSVELHANVTCNNEDSDLLEDNSATTIIPILYPINILIQDQED 932

  Fly   829 SQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEY 893
            |.::..||      ...||:..|.|. |.:...|.        ::...:||:|
Human   933 STLYVSFT------PKGPKIHQVKHM-YQVRIQPS--------IHDHNIPTLE------------ 970

  Fly   894 VNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRV 958
                          |.:..|..    ||:..       |..|.|.........|.:|
Human   971 --------------AVVGVPQP----PSEGP-------ITHQWSVQMEPPVPCHYED-------- 1002

  Fly   959 RRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNMPALSEAQVVVKA 1023
                      ||||   |:::.            .|..||         :...|.:...:::|:.
Human  1003 ----------LERL---PDAAE------------PCLPGA---------LFRCPVVFRQEILVQV 1033

  Fly  1024 RLWNSTLVSEYPRVERVRIFSTATAQIPES-----YG-----VEVMDHNNIEVETRAYPELRNQQ 1078
             :....||.|........:.|:.:.....|     ||     .:|:...::..|.:
Human  1034 -IGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQ--------- 1088

  Fly  1079 RDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGNL-EKM 1129
                :.:|.::.|| ||||||.|:..||:|||||||          || |||
Human  1089 ----MLYLYVLSGI-GGLLLLLLIFIVLYKVGFFKR----------NLKEKM 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	20/72 (28%)
		Int_alpha	317..368	CDD:214549	19/51 (37%)
		Int_alpha	378..428	CDD:214549	23/49 (47%)
		Int_alpha	446..491	CDD:214549	17/48 (35%)
		Integrin_alpha2	479..1006	CDD:285619	105/563 (19%)
ITGAL	NP_002200.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	31..82		18/67 (27%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	83..141		18/87 (21%)
		vWA_integrins_alpha_subunit	155..323	CDD:238746	14/167 (8%)
		I-domain (insertion domain)	170..349		18/178 (10%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	390..445		10/57 (18%)
		Int_alpha	402..451	CDD:214549	11/51 (22%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	446..506		21/61 (34%)
		Int_alpha	456..503	CDD:214549	18/48 (38%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	507..563		25/56 (45%)
		Int_alpha	517..569	CDD:214549	25/52 (48%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	567..627		22/68 (32%)
		Int_alpha	579..>603	CDD:214549	9/23 (39%)
		Integrin_alpha2	612..983	CDD:285619	92/481 (19%)
		GFFKR motif	1115..1119		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1128..1170
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141998
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740