Protein Alignment mew and ITGAD

DIOPT Version :10

• Sequence 1: NP_001285196.1
• Gene: mew / 32275
• FlyBaseID: FBgn0004456
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: XP_011544137.1
• Gene: ITGAD / 3681
• HGNCID: 6146
• Length: 1190
• Species: Homo sapiens
• Alignment Length: 1031
• Identity: 240/1031 - (23%)
• Similarity: 401/1031 - (38%)
• Gaps: 302/1031 - (29%)

  Fly   198 QHEDYGLCQAGTSAALL----------DDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYS 252
            |||   :.|.|.|.||.          ..|.:.||:.|.::|.|..::      |......|:.:
Human   347 QHE---MSQEGFSTALTMSLPSPGILSSQDGLFLGAVGSFSWSGGAFL------YPPNMSPTFIN 402

  Fly   253 ---DHSDLNSPVDKYSYLGMSVTGGRFFGHMSYAAGAPRSEGHGQVVIFD-------KSTDNPIP 307
               ::.|:..     ||||.|.....:.|..:...||||.:..|:.|||.       |..:
Human   403 MSQENVDMRD-----SYLGYSTELALWKGVQNLVLGAPRYQHTGKAVIFTQVSRQWRKKAE---- 458

  Fly   308 VHSILDGEQFGSSFGYELATADINGDHRPDLI-VAAPLYFTKTEGGAVYVY-----QNIQ---DT 363
                :.|.|.||.||..|.:.|::.|...||| :.||.|:.:|.||.|.|.     |.:|   |.
Human   459 ----VTGTQIGSYFGASLCSVDVDSDGSTDLILIGAPHYYEQTRGGQVSVCPLPRGQRVQWQCDA 519

  Fly   364 LPMKYTLKLTGPLE---SRFGLALANIGDLNKDNCEDLAVGAP--YEGNGVVYIYLGSSQ-GLNS 422
            :       |.|...   .|||.||..:||:|:|...|:|:|||  .|..|.||::.|:|: |::.
Human   520 V-------LRGEQGHPWGRFGAALTVLGDVNEDKLIDVAIGAPGEQENRGAVYLFHGASESGISP 577

  Fly   423 KPAQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQT 487
            ..:|:|.:|:|.   |.   ::.||.::||..||..:...|:.:||  ....::|.:.|::.:..
Human   578 SHSQRIASSQLS---PR---LQYFGQALSGGQDLTQDGLMDLAVGA--RGQVLLLRSLPVLKVGV 634

  Fly   488 SVQ------RKELHNMDPNTPGCLDDPASNLT-CFTFRACCSIEPYDEKNKELRLAYSVEAETFD 545
            :::      .|.::......|..|:  |.:.| |.|.:. .|::...:....:|...::     |
Human   635 AMRFSPVEVAKAVYRCWEEKPSALE--AGDATVCLTIQK-SSLDQLGDIQSSVRFDLAL-----D 691

  Fly   546 HLKKFSRVFFFDREN---KRTNVLSRVVRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLV 607
            ..:..||..|.:.:|   .|...|.  :.:|      |:.:...:.....|:.:|:...|.:|||
Human   692 PGRLTSRAIFNETKNPTLTRRKTLG--LGIH------CETLKLLLPDCVEDVVSPIILHLNFSLV 748

  Fly   608 EPPLADSALVRLNPIL-----DQTQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITES-SGNEY 666
            ..|:....  .|.|:|     |...|.:.||    |:||.|.|||.:|      .:|.| ||.:.
Human   749 REPIPSPQ--NLRPVLAVGSQDLFTASLPFE----KNCGQDGLCEGDL------GVTLSFSGLQT 801

  Fly   667 TLILDETELEVRINVSNLADSAYEAQLFIAHQAGVSYVATKKPTNATCNSYNTTL-VACSLGNPM 730
            ..:....||.|.:.|.|..:.:|...:.:.:.||:|:   ::.:.|....:.:.| :||.
Human   802 LTVGSSLELNVIVTVWNAGEDSYGTVVSLYYPAGLSH---RRVSGAQKQPHQSALRLACE----- 858

  Fly   731 LRDTTTFVTIRFQPKGLEPSEKIM---LFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWA 792
                    |:..:.:||..|...:   :||..:|.|..:......:..|...::.||
Human   859 --------TVPTEDEGLRSSRCSVNHPIFHEGSNGTFIVTFDVSYKATLGDRMLMRA-------- 907

  Fly   793 IPEQSFYSGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYS 857
                   |.||..|..:::.||                                 .|:.:...|:
Human   908 -------SASSENNKASSSKAT---------------------------------FQLELPVKYA 932

  Fly   858 LYS----DPQSGRPVQYLLYL------------------EQVPTVE-------VSQGECHVAKEY 893
            :|:    .|..|.|:..|.:|                  :::...|       :||.:..::..:
Human   933 VYTMISRCPVPGLPLGPLAFLYAWQEESTKYFNFATSDEKKMKEAEHRYRVNNLSQRDLAISINF 997

  Fly   894 VNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRV 958
            ..|: |.:|.......:.||:|.....|:.:                   ...|||
Human   998 WVPV-LLNGVAVWDVVMEAPSQSLPCVSERK-------------------PPQHSD--------- 1033

  Fly   959 RRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNMPALSEAQVVVKA 1023
               ||.:::|...                    |||:  ..:|::..||:.:.....|....:|.
Human  1034 ---FLTQISRSPM--------------------LDCS--IADCLQFRCDVPSFSVQEELDFTLKG 1073

  Fly  1024 RL---W-NSTLVSEYPRVERVRI-FSTAT-AQIPESYGVEVMDHNNIEV---ETRAYPELRNQQR 1079
            .|   | ..||..:...|....| |.|:. :|:|   |.|......:|:   |...|
Human  1074 NLSFGWVRETLQKKVLVVSVAEITFDTSVYSQLP---GQEAFMRAQMEMVLEEDEVY-------- 1127

  Fly  1080 DTSIPWLIIILG-IVGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGNLEKMNEEKP 1134
             .:||   ||:| .||.||||||:|..|:|:|||||          :.::|.|:||
Human  1128 -NAIP---IIMGSSVGALLLLALITATLYKLGFFKR----------HYKEMLEDKP 1169

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549
		Int_alpha	317..368	CDD:214549	21/59 (36%)
		Int_alpha	378..428	CDD:214549	22/52 (42%)
		Int_alpha	446..491	CDD:214549	11/50 (22%)
		Integrin_alpha2	480..1006	CDD:462478	103/574 (18%)
ITGAD	XP_011544137.1	vWA_integrins_alpha_subunit	149..324	CDD:238746
		Int_alpha	464..>506	CDD:214549	18/41 (44%)
		Int_alpha	528..583	CDD:214549	22/54 (41%)
		Int_alpha	593..>625	CDD:214549	9/33 (27%)
		Integrin_alpha2	628..>933	CDD:462478	77/396 (19%)
		Integrin_alpha	1153..1167	CDD:459778	7/23 (30%)