DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mew and ITGA9

DIOPT Version :9

Sequence 1:NP_001285196.1 Gene:mew / 32275 FlyBaseID:FBgn0004456 Length:1243 Species:Drosophila melanogaster
Sequence 2:NP_002198.2 Gene:ITGA9 / 3680 HGNCID:6145 Length:1035 Species:Homo sapiens


Alignment Length:1235 Identity:319/1235 - (25%)
Similarity:518/1235 - (41%) Gaps:298/1235 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 RLRQNLGILIILQCVLTCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAP 78
            |||..|..|::.......|  ||:.:.|:...|...|.|||:|..|.      .:.|..||||||
Human    12 RLRALLLALVVAGIPAGAY--NLDPQRPVHFQGPADSFFGYAVLEHF------HDNTRWVLVGAP 68

  Fly    79 -LDQNRQPNTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGND----------EIKED 132
             .|....|:....||:::|          :|.|:..|.. :|:....|.:          |.::|
Human    69 KADSKYSPSVKSPGAVFKC----------RVHTNPDRRC-TELDMARGKNRGTSCGKTCREDRDD 122

  Fly   133 QWMGVTVRSNPLQANGSGGKVIVCAHRY--MYIVRENRYGQGLCYLLTNDLQFE-EVHEPCKGRP 194
            :||||::...|    .:.|:|:.||||:  :|...::....|.||::.::||.: ....||....
Human   123 EWMGVSLARQP----KADGRVLACAHRWKNIYYEADHILPHGFCYIIPSNLQAKGRTLIPCYEEY 183

  Fly   195 VQRQHEDYGLCQAGTSAALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSDLNS 259
            .::..|::|.||||. |....::.:|:|:||.:.|.|:|.|       |.....||..    ||.
Human   184 KKKYGEEHGSCQAGI-AGFFTEELVVMGAPGSFYWAGTIKV-------LNLTDNTYLK----LND 236

  Fly   260 PV---DKYSYLGMSVTGGRFFGHMS---YAAGAPRSEGHGQVVIF--DKSTDNPIPVHSILDGEQ 316
            .|   .:|:|||.:||.|. |.|.|   ...|||:.:|.|:|.||  |:.:...|.:.. ..|::
Human   237 EVIMNRRYTYLGYAVTAGH-FSHPSTIDVVGGAPQDKGIGKVYIFRADRRSGTLIKIFQ-ASGKK 299

  Fly   317 FGSSFGYELATADINGDHRPDLIVAAPLYFTKTEGGAVYVYQNIQDTLPMKYTLKLT--GPLESR 379
            .||.||..|...|:|||...||:|.||::....:.|.|.||.| :....::..|.||  |...:.
Human   300 MGSYFGSSLCAVDLNGDGLSDLLVGAPMFSEIRDEGQVTVYIN-RGNGALEEQLALTGDGAYNAH 363

  Fly   380 FGLALANIGDLNKDNCEDLAVGAPYEGN--GVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQP 442
            ||.::|::.||:.|...|:|:|||.|.:  |.||||.|.:.|:..:.:.|:...::...      
Human   364 FGESIASLDDLDNDGFPDVAIGAPKEDDFAGAVYIYHGDAGGIVPQYSMKLSGQKINPV------ 422

  Fly   443 IRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPNTPGCLD- 506
            :|.||.||||..|:|.|.||||.:|||.|.:.|:|.|||:|::..|:......|:  ..|.|.| 
Human   423 LRMFGQSISGGIDMDGNGYPDVTVGAFMSDSVVLLRARPVITVDVSIFLPGSINI--TAPQCHDG 485

  Fly   507 -DPASNL---TCFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLK-KFSRVFFFDRENKRTNVL 566
             .|.:.|   |||:|..       .....|:.|.|.:.|:.....| :..||:|           
Human   486 QQPVNCLNVTTCFSFHG-------KHVPGEIGLNYVLMADVAKKEKGQMPRVYF----------- 532

  Fly   567 SRVVRVHTNGR-TE----------CQAVTGYIKANTRDIQTPVRFRLKYSLVE----------PP 610
              |:...|.|: ||          |:....::|...:|:.:|:.|...|||.|          ||
Human   533 --VLLGETMGQVTEKLQLTYMEETCRHYVAHVKRRVQDVISPIVFEAAYSLSEHVTGEEERELPP 595

  Fly   611 LADSALVRLNPIL-----------DQTQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGN 664
                    |.|:|           :||        .|:::|..:| |.::|  :::..:..||.:
Human   596 --------LTPVLRWKKGQKIAQKNQT--------VFERNCRSED-CAADL--QLQGKLLLSSMD 641

  Fly   665 EYTLIL---DETELEVRINVSNLADSAYEA--------QLFIAHQAGVSYVATKKPTNATCNSYN 718
            |.||.|   ....:.:.|::|||.|.||:|        :||..:      :..|:....:|....
Human   642 EKTLYLALGAVKNISLNISISNLGDDAYDANVSFNVSRELFFIN------MWQKEEMGISCELLE 700

  Fly   719 TTLVACSLGNPMLRDTTTF-VTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERPE--RD----L 776
            :..:.||:|.|.:|..:.: .::.|....|...|:::.|.:    |::....||.|  .|    |
Human   701 SDFLKCSVGFPFMRSKSKYEFSVIFDTSHLSGEEEVLSFIV----TAQSGNTERSESLHDNTLVL 761

  Fly   777 RVNVVRRAKLNFRGWAIPEQSFYSGSSV--ANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFN 839
            .|.::.....:..|...| .||..|.||  ||.:   ...|:|.|        ...::....::|
Human   762 MVPLMHEVDTSITGIMSP-TSFVYGESVDAANFI---QLDDLECH--------FQPINITLQVYN 814

  Fly   840 EGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSR 904
            .||||.|...:.|.:|..|.|.......||.::       |...:|.|...|             
Human   815 TGPSTLPGSSVSISFPNRLSSGGAEMFHVQEMV-------VGQEKGNCSFQK------------- 859

  Fly   905 ENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRL 969
             ||.....|.:            .:::.|:..::::.|                           
Human   860 -NPTPCIIPQE------------QENIFHTIFAFFTKS--------------------------- 884

  Fly   970 ERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNMPALS--EAQVVVKARLWNSTLVS 1032
                          |:|    .|||.|...:|:...|   |..||:  |::.:....|.|:.::.
Human   885 --------------GRK----VLDCEKPGISCLTAHC---NFSALAKEESRTIDIYMLLNTEILK 928

  Fly  1033 EYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYPELRN-QQRDTSIPWLIIILGIVGGL 1096
            : .....::..|.|..::..:..|..:.|.|.|..|..:..|.| :.|...:.| ||.:.::.|:
Human   929 K-DSSSVIQFMSRAKVKVDPALRVVEIAHGNPEEVTVVFEALHNLEPRGYVVGW-IIAISLLVGI 991

  Fly  1097 LLLALVTYVLWKVGFFKRIRPTDPTLSGNLEKMNEEKPFLAPSKNTHHVFXQEGTVGWDLVRRRR 1161
            |:..|:..:|||:|||:|                ..|..:...||     .:|....||.|::.:
Human   992 LIFLLLAVLLWKMGFFRR----------------RYKEIIEAEKN-----RKENEDSWDWVQKNQ 1035

  Fly  1162  1161
            Human  1036  1035

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mewNP_001285196.1 Int_alpha 48..111 CDD:214549 19/63 (30%)
Int_alpha 317..368 CDD:214549 19/50 (38%)
Int_alpha 378..428 CDD:214549 19/51 (37%)
Int_alpha 446..491 CDD:214549 24/44 (55%)
Integrin_alpha2 479..1006 CDD:285619 123/584 (21%)
ITGA9NP_002198.2 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 35..96 22/76 (29%)
Int_alpha 44..101 CDD:214549 22/73 (30%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 111..174 19/66 (29%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 182..232 17/57 (30%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 233..289 22/60 (37%)
Int_alpha 244..294 CDD:214549 20/50 (40%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 290..349 21/60 (35%)
Int_alpha 300..347 CDD:214549 19/47 (40%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 351..408 23/56 (41%)
Int_alpha 361..414 CDD:214549 19/52 (37%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 411..474 26/68 (38%)
Int_alpha 425..>466 CDD:214549 23/40 (58%)
Integrin_alpha2 459..903 CDD:285619 123/584 (21%)
GFFKR motif 1005..1009 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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