DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mew and ITGA5

DIOPT Version :9

Sequence 1:NP_001285196.1 Gene:mew / 32275 FlyBaseID:FBgn0004456 Length:1243 Species:Drosophila melanogaster
Sequence 2:NP_002196.4 Gene:ITGA5 / 3678 HGNCID:6141 Length:1049 Species:Homo sapiens


Alignment Length:1155 Identity:305/1155 - (26%)
Similarity:481/1155 - (41%) Gaps:236/1155 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 FNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNRQPNTTHSGALWRCPM 98
            |||:...|.|..|.|.|.||:||..:..| .:|.:    ||||||.....||.....||::.||.
Human    42 FNLDAEAPAVLSGPPGSFFGFSVEFYRPG-TDGVS----VLVGAPKANTSQPGVLQGGAVYLCPW 101

  Fly    99 TQRFDDCEQVITD--GRRNFDSEILSPPGND--EIKEDQWMGVTVRSNPLQANGSGGKVIVCAHR 159
            ......|..:..|  |.|..:|.:.|..|.:  |.|..||.|.|||::       |..::.||..
Human   102 GASPTQCTPIEFDSKGSRLLESSLSSSEGEEPVEYKSLQWFGATVRAH-------GSSILACAPL 159

  Fly   160 YMYIVRENRYGQ--GLCYLLTNDLQFEEVHEPCKGRPVQRQHEDY------GLCQAGTSAALLDD 216
            |.:...:.....  |.|||.|::......:.||:        .|:      |.||.|.||.....
Human   160 YSWRTEKEPLSDPVGTCYLSTDNFTRILEYAPCR--------SDFSWAAGQGYCQGGFSAEFTKT 216

  Fly   217 DTMVLGSPGPYTWRGSI----------------WVTQVGGEYLQRDKTTYYSDHSDLNSPVDKYS 265
            ..:|||.||.|.|:|.|                .:..|.|:...|..::.|.|           |
Human   217 GRVVLGGPGSYFWQGQILSATQEQIAESYYPEYLINLVQGQLQTRQASSIYDD-----------S 270

  Fly   266 YLGMSVTGGRFFGH--MSYAAGAPRSE-GHGQVVIFDKSTDNPIPVHSI--LDGEQFGSSFGYEL 325
            |||.||..|.|.|.  ..:.||.|:.. .:|.|.|.:.|     .:.|:  ..|||..|.|||.:
Human   271 YLGYSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTILNGS-----DIRSLYNFSGEQMASYFGYAV 330

  Fly   326 ATADINGDHRPDLIVAAPLYFTKT------EGGAVYVYQNIQDTLPMKYTLKLTGPLE-SRFGLA 383
            |..|:|||...||:|.|||...:|      |.|.||||......:....||.|||..| .|||.:
Human   331 AATDVNGDGLDDLLVGAPLLMDRTPDGRPQEVGRVYVYLQHPAGIEPTPTLTLTGHDEFGRFGSS 395

  Fly   384 LANIGDLNKDNCEDLAVGAPYEG---NGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRT 445
            |..:|||::|...|:|:|||:.|   .|||:::.|...||.|||:|.:|........|:     .
Human   396 LTPLGDLDQDGYNDVAIGAPFGGETQQGVVFVFPGGPGGLGSKPSQVLQPLWAASHTPD-----F 455

  Fly   446 FGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQ-RKELHNMDPNTPGCLDDPA 509
            ||.::.|..|||.|.|||:::|:|....||:...|||:|...|:. ...:.|.:..:.....:| 
Human   456 FGSALRGGRDLDGNGYPDLIVGSFGVDKAVVYRGRPIVSASASLTIFPAMFNPEERSCSLEGNP- 519

  Fly   510 SNLTCFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKK---FSRVFFFDRENKRTNVLSRVVR 571
              :.|.....|.:.   ..|:....:.::||.: .|..|:   ..|..|.   ..|...|::.:.
Human   520 --VACINLSFCLNA---SGKHVADSIGFTVELQ-LDWQKQKGGVRRALFL---ASRQATLTQTLL 575

  Fly   572 VHTNGRTECQAVTGYIK--ANTRDIQTPVRFRLKYSLVEPPLADSALVRLNPILD-QTQAHVDFE 633
            :....|.:|:.:..|::  :..||..:|:...|.:||......||.  .|.|.|. |:::.::.:
Human   576 IQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPQAPVDSH--GLRPALHYQSKSRIEDK 638

  Fly   634 GTFQKDCGDDDLCESNLIIRV--EPNITESSGNEYTLILDETELEVRINVSNLAD-SAYEAQLFI 695
            .....|||:|::|..:|.:.|  |.|        :..:.|:..|.:..:..|:.: .||||:|.:
Human   639 AQILLDCGEDNICVPDLQLEVFGEQN--------HVYLGDKNALNLTFHAQNVGEGGAYEAELRV 695

  Fly   696 AHQAGVSYVA-TKKPTN---ATCNSY---NTTLVACSLGNPMLRDTTTFVTIRFQPKGLEPSEKI 753
            .......|.. .:.|.|   .:|:.:   .:.|:.|.|||||....:.:..:||....|..::|.
Human   696 TAPPEAEYSGLVRHPGNFSSLSCDYFAVNQSRLLVCDLGNPMKAGASLWGGLRFTVPHLRDTKKT 760

  Fly   754 MLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEG 818
            :.|. |...:..|...:......|::|..:|::...|.:.||       :|...|::....|   
Human   761 IQFD-FQILSKNLNNSQSDVVSFRLSVEAQAQVTLNGVSKPE-------AVLFPVSDWHPRD--- 814

  Fly   819 HGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVS 883
             .|...:|:|..|||::.:.|:|||:..:..:.:..|.:|..        |.|||:.:|..:..:
Human   815 -QPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQALEG--------QQLLYVTRVTGLNCT 870

  Fly   884 QGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHS 948
            ..         :|:|              |..:.:.|..|.|       |.|:            
Human   871 TN---------HPIN--------------PKGLELDPEGSLH-------HQQK------------ 893

  Fly   949 DDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNMPA 1013
                      |.:              |..|:|::|.:    .|.|.:  ..|.|:.|::..:..
Human   894 ----------REA--------------PSRSSASSGPQ----ILKCPE--AECFRLRCELGPLHQ 928

  Fly  1014 LSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYPELRNQQ 1078
            .....:.:..|:|..|.:.        |.....:.|....|....|.:   .:..|..|: :.:|
Human   929 QESQSLQLHFRVWAKTFLQ--------REHQPFSLQCEAVYKALKMPY---RILPRQLPQ-KERQ 981

  Fly  1079 RDTSIPWL-----------IIILGIVGGLLLLALVTYVLWKVGFFKRIRP 1117
            ..|::.|.           ||||.|:.|||||.|:.|:|:|:|||||..|
Human   982 VATAVQWTKAEGSYGVPLWIIILAILFGLLLLGLLIYILYKLGFFKRSLP 1031

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mewNP_001285196.1 Int_alpha 48..111 CDD:214549 21/62 (34%)
Int_alpha 317..368 CDD:214549 22/56 (39%)
Int_alpha 378..428 CDD:214549 24/52 (46%)
Int_alpha 446..491 CDD:214549 19/45 (42%)
Integrin_alpha2 479..1006 CDD:285619 111/543 (20%)
ITGA5NP_002196.4 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 43..108 25/69 (36%)
Int_alpha 56..114 CDD:214549 21/62 (34%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 128..188 18/66 (27%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 192..245 17/60 (28%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 259..311 19/67 (28%)
Int_alpha 268..>310 CDD:214549 17/57 (30%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 312..377 26/64 (41%)
Int_alpha 322..379 CDD:214549 22/56 (39%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 378..437 26/58 (45%)
Int_alpha 389..443 CDD:214549 24/53 (45%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 441..504 22/67 (33%)
Int_alpha 455..498 CDD:214549 18/42 (43%)
Integrin_alpha2 490..921 CDD:312071 111/542 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 877..907 11/72 (15%)
Interaction with HPS5 1021..1028 4/6 (67%)
GFFKR motif 1024..1028 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11211
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D325432at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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