DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and ITGA2B

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_000410.2	Gene:	ITGA2B / 3674	HGNCID:	6138	Length:	1039	Species:	Homo sapiens

Alignment Length:	1195	Identity:	314/1195 - (26%)
Similarity:	494/1195 - (41%)	Gaps:	258/1195 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ILIILQCVL-TCYNFNLEQRLPIVKYGHPH-SHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNR 83
            :|::..|.. ..:..||:. :.:..|..|: |.||:|:..|.  :::|   ...::||||  :..
Human    18 LLLLGPCAAPPAWALNLDP-VQLTFYAGPNGSQFGFSLDFHK--DSHG---RVAIVVGAP--RTL 74

  Fly    84 QPNTTHSGALWRCPMTQRFDDCEQVITDGR---RNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQ 145
            .|:...:|.::.||.......|..::.|.|   ||..|:.|     ...|..|.:|.:|.|
Human    75 GPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTL-----QTFKARQGLGASVVS---- 130

  Fly   146 ANGSGGKVIVCAHRYMYIVRE-----NRYGQGLCYLLTNDLQFEEVHEPCKGRPVQRQHE----- 200
               ....::.||....:.|.|     .:...|.|:|...:......:.||:|..:.|.:.
Human   131 ---WSDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFS 192

  Fly   201 -DYGLCQAGTSAALLDDDTMVLGSPGPYTWRGSIW---VTQVGGEYLQRDKTTYYSDHS---DLN 258
             |...|:||.|:.:.....:|||:||.|.:.|.:.   |..:...|.......:.|..|   |.:
Human   193 WDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSS 257

  Fly   259 SPVDKYSYLGMSVTGGRFFGHMS---YAAGAPR-SEGHGQVVIFDKSTDNPIPVHSILDGEQFGS 319
            :|.....|.|.||..|.|.|.::   |..|||. |...|.|.|.|.....   :|. |.|||..|
Human   258 NPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQR---LHR-LRGEQMAS 318

  Fly   320 SFGYELATADINGDHRPDLIVAAPLYFTK------TEGGAVYVYQNIQDTLPMKY---TLKLTG- 374
            .||:.:|..|:|||.|.||:|.||||...      .|.|.||::  :|...|...   :|.|||
Human   319 YFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLF--LQPRGPHALGAPSLLLTGT 381

  Fly   375 PLESRFGLALANIGDLNKDNCEDLAVGAPY---EGNGVVYIYLGSSQGLNSKPAQKIQASELGGT 436
            .|..|||.|:|.:|||::|...|:||.|||   .|.|.|.::||.|:||.|:|:|     .|...
Human   382 QLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQ-----VLDSP 441

  Fly   437 IPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPII--SIQTSVQRKELHNMDP 499
            .|.|.   .||.|:.|..|:|||.|||:::||:.::...:..|:|::  |:|..||    .:::|
Human   442 FPTGS---AFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQLLVQ----DSLNP 499

  Fly   500 NTPGC-LDDPASNLTCFTFRACCSIEPYDEKNKELRLAYSVEAE-TFDHLKKFSRVFFFDRENKR 562
            ....| |....:.::||..:.|.....::...|     .|:.|| ..|..|        .|:.:|
Human   500 AVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQK-----LSLNAELQLDRQK--------PRQGRR 551

  Fly   563 TNVL-----SRVVRVHTNGRTE--CQAVTGYIK--ANTRDIQTPVRFRLKYSLVEPP----LADS 614
            ..:|     ...:.:...|:..  |.....:::  |:.||..:|:...|..||  ||    :|.:
Human   552 VLLLGSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSL--PPTEAGMAPA 614

  Fly   615 ALVRLNPILDQTQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRI 679
            .::       ....||..:.....|||:||:|...|      .:|.|......|:..:..||:::
Human   615 VVL-------HGDTHVQEQTRIVLDCGEDDVCVPQL------QLTASVTGSPLLVGADNVLELQM 666

  Fly   680 NVSNLADSAYEAQLFIAHQAGVSYVATKKPTNA----TCN---SYNTTLVACSLGNPMLRDTTTF 737
            :.:|..:.||||:|.:....|..|:........    .||   ...|.:|.|.|||||.::....
Human   667 DAANEGEGAYEAELAVHLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCELGNPMKKNAQIG 731

  Fly   738 VTIRFQPKGLEPSEKIMLFHI------FANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQ 796
            :.:......||.:.:.:.|.:      ..|..||:|..:.|.|       ..|::..||.:.|
Human   732 IAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVR-------AEAQVELRGNSFP-- 787

  Fly   797 SFYSGSSVANSVANTAATDIEGHGPM-GMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWP----- 855
                        |:......||.... .:|..|.:|.|.:.:.|.||.|...:.:.||.|
Human   788 ------------ASLVVAAEEGEREQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQP 840

  Fly   856 ----YSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQM 916
                |.|...||.|     |....|.|               ||||.:..|       |..|:..
Human   841 SDLLYILDIQPQGG-----LQCFPQPP---------------VNPLKVDWG-------LPIPSPS 878

  Fly   917 RMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNA 981
            .:.|:.                    |:.|.           |:.||.          :||..:
Human   879 PIHPAH--------------------HKRDR-----------RQIFLP----------EPEQPS- 901

  Fly   982 ANGKKQDIVELDCNKGATNCVRIECDILNMPALSEAQVVVKARLWNSTLVSEYPR-VERVRIFST 1045
               :.||.|.:.|:  :..|..::||:..|.....|.|.|.|.||   |.|.|.| :::..:.|.
Human   902 ---RLQDPVLVSCD--SAPCTVVQCDLQEMARGQRAMVTVLAFLW---LPSLYQRPLDQFVLQSH 958

  Fly  1046 A---TAQIPESYGVEVMDHNNIEVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLW 1107
            |   .:.:|  |.|..:  :....|.:.:.:|.....:.:||...:::|::||||||.::...:|
Human   959 AWFNVSSLP--YAVPPL--SLPRGEAQVWTQLLRALEERAIPIWWVLVGVLGGLLLLTILVLAMW 1019

  Fly  1108 KVGFFKRIRPTDPTLSGNLEKMNEE 1132
            |||||||.||.       ||:.:||
Human  1020 KVGFFKRNRPP-------LEEDDEE 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	16/63 (25%)
		Int_alpha	317..368	CDD:214549	22/56 (39%)
		Int_alpha	378..428	CDD:214549	26/52 (50%)
		Int_alpha	446..491	CDD:214549	18/46 (39%)
		Integrin_alpha2	479..1006	CDD:285619	120/566 (21%)
ITGA2B	NP_000410.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	35..96		16/68 (24%)
		Int_alpha	46..102	CDD:214549	15/62 (24%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	110..173		14/74 (19%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	187..238		13/50 (26%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	251..305		19/53 (36%)
		Int_alpha	262..>302	CDD:214549	15/39 (38%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	306..371		27/70 (39%)
		Int_alpha	316..367	CDD:214549	21/52 (40%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	373..432		28/58 (48%)
		Int_alpha	384..438	CDD:214549	26/58 (45%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	435..496		23/72 (32%)
		Int_alpha	445..>485	CDD:214549	16/42 (38%)
		Integrin_alpha2	481..921	CDD:285619	120/566 (21%)
		Integrin_alpha	1020..1034	CDD:278771	11/20 (55%)
		GFFKR motif	1022..1026		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142043
Domainoid	1	1.000	54	1.000	Domainoid score	I11211
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750