Protein Alignment mew and ITGA2B

DIOPT Version :10

• Sequence 1: NP_001285196.1
• Gene: mew / 32275
• FlyBaseID: FBgn0004456
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: XP_011523051.2
• Gene: ITGA2B / 3674
• HGNCID: 6138
• Length: 1056
• Species: Homo sapiens
• Alignment Length: 1191
• Identity: 309/1191 - (25%)
• Similarity: 481/1191 - (40%)
• Gaps: 284/1191 - (23%)

  Fly    21 ILIILQCVL-TCYNFNLEQRLPIVKYGHPH-SHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNR 83
            :|::..|.. ..:..||:. :.:..|..|: |.||:|:..|.  :::|   ...::||||  :..
Human    69 LLLLGPCAAPPAWALNLDP-VQLTFYAGPNGSQFGFSLDFHK--DSHG---RVAIVVGAP--RTL 125

  Fly    84 QPNTTHSGALWRCPMTQRFDDCEQVITDGR---RNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQ 145
            .|:...:|.::.||.......|..::.|.|   ||..|:.|     ...|..|.:|.:|.|
Human   126 GPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTL-----QTFKARQGLGASVVS---- 181

  Fly   146 ANGSGGKVIVCAHRYMYIVRE-----NRYGQGLCYLLTNDLQFEEVHEPCKGRPVQRQHE----- 200
               ....::.||....:.|.|     .:...|.|:|...:......:.||:|..:.|.:.
Human   182 ---WSDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFS 243

  Fly   201 -DYGLCQAGTSAALLDDDTMVLGSPGPYTWRGSIW---VTQVGGEYLQRDKTTYYSDHS---DLN 258
             |...|:||.|:.:.....:|||:||.|.:.|.:.   |..:...|.......:.|..|   |.:
Human   244 WDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSS 308

  Fly   259 SPVDKYSYLGMSVTGGRFFGHMS---YAAGAPR-SEGHGQVVIFDKSTDNPIPVHSILDGEQFGS 319
            :|.....|.|.||..|.|.|.::   |..|||. |...|.|.|.|.....   :|. |.|||..|
Human   309 NPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQR---LHR-LRGEQMAS 369

  Fly   320 SFGYELATADINGDHRPDLIVAAPLYFTK------TEGGAVYVYQNIQDTLPMKY---TLKLTG- 374
            .||:.:|..|:|||.|.||:|.||||...      .|.|.||::  :|...|...   :|.|||
Human   370 YFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLF--LQPRGPHALGAPSLLLTGT 432

  Fly   375 PLESRFGLALANIGDLNKDNCEDLAVGAPY---EGNGVVYIYLGSSQGLNSKPAQKIQASELGGT 436
            .|..|||.|:|.:|||::|...|:||.|||   .|.|.|.::||.|:||.|:|:|     .|...
Human   433 QLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQ-----VLDSP 492

  Fly   437 IPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPII--SIQTSVQRKELHNMDP 499
            .|.|.   .||.|:.|..|:|||.|||:::||:.::...:..|:|::  |:|..||    .:::|
Human   493 FPTGS---AFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQLLVQ----DSLNP 550

  Fly   500 NTPGC-LDDPASNLTCFTFRACCSIEPYDEKNKELRLAYSVEAE-TFDHLKKFSRVFFFDRENKR 562
            ....| |....:.::||..:.|.....::...|     .|:.|| ..|..|        .|:.:|
Human   551 AVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQK-----LSLNAELQLDRQK--------PRQGRR 602

  Fly   563 TNVL-----SRVVRVHTNGRTE--CQAVTGYIK--ANTRDIQTPVRFRLKYSLVEPP----LADS 614
            ..:|     ...:.:...|:..  |.....:::  |:.||..:|:...|..||  ||    :|.:
Human   603 VLLLGSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSL--PPTEAGMAPA 665

  Fly   615 ALVRLNPILDQTQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRI 679
            .::       ....||..:.....|||:||:|...|      .:|.|......|:..:..||:::
Human   666 VVL-------HGDTHVQEQTRIVLDCGEDDVCVPQL------QLTASVTGSPLLVGADNVLELQM 717

  Fly   680 NVSNLADSAYEAQLFIAHQAGVSYVATKKPTNA----TCN---SYNTTLVACSLGNPMLRDTTTF 737
            :.:|..:.||||:|.:....|..|:........    .||   ...|.:|.|.|||||.::....
Human   718 DAANEGEGAYEAELAVHLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCELGNPMKKNAQIG 782

  Fly   738 VTIRFQPKGLEPSEKIMLFHI------FANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQ 796
            :.:......||.:.:.:.|.:      ..|..||:|..:.|.|       ..|::..||.:.|
Human   783 IAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVR-------AEAQVELRGNSFP-- 838

  Fly   797 SFYSGSSVANSVANTAATDIEGHGPM-GMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWP----- 855
                        |:......||.... .:|..|.:|.|.:.:.|.||.|...:.:.||.|
Human   839 ------------ASLVVAAEEGEREQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQP 891

  Fly   856 ----YSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQM 916
                |.|...||.|     |....|.|               ||||.:..|       |..|:..
Human   892 SDLLYILDIQPQGG-----LQCFPQPP---------------VNPLKVDWG-------LPIPSPS 929

  Fly   917 RMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNA 981
            .:.|:.                    |:.|.           |:.||.          :||..:
Human   930 PIHPAH--------------------HKRDR-----------RQIFLP----------EPEQPS- 952

  Fly   982 ANGKKQDIVELDCNKGATNCVRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTA 1046
               :.||.|.:.|:  :..|..::||:..|.....|.|.|.|.||..:|...:.::.|.
Human   953 ---RLQDPVLVSCD--SAPCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQVWTQLLRA------ 1006

  Fly  1047 TAQIPESYGVEVMDHNNIEVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGF 1111
                               :|.||.|          |.|  :::|::||||||.::...:|||||
Human  1007 -------------------LEERAIP----------IWW--VLVGVLGGLLLLTILVLAMWKVGF 1040

  Fly  1112 FKRIRPTDPTLSGNLEKMNEE 1132
            |||.||.       ||:.:||
Human  1041 FKRNRPP-------LEEDDEE 1054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	16/63 (25%)
		Int_alpha	317..368	CDD:214549	22/56 (39%)
		Int_alpha	378..428	CDD:214549	26/52 (50%)
		Int_alpha	446..491	CDD:214549	18/46 (39%)
		Integrin_alpha2	480..1006	CDD:462478	119/565 (21%)
ITGA2B	XP_011523051.2	Int_alpha	97..153	CDD:214549	15/62 (24%)
		Int_alpha	313..>353	CDD:214549	15/39 (38%)
		Int_alpha	367..418	CDD:214549	21/52 (40%)
		Int_alpha	435..489	CDD:214549	26/58 (45%)
		Int_alpha	496..>536	CDD:214549	16/42 (38%)
		Integrin_alpha2	533..972	CDD:462478	119/565 (21%)
		Integrin_alpha	1037..1051	CDD:459778	11/20 (55%)