DRSC/TRiP Functional Genomics Resources

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Protein Alignment mew and ITGA2

DIOPT Version :9

Sequence 1:NP_001285196.1 Gene:mew / 32275 FlyBaseID:FBgn0004456 Length:1243 Species:Drosophila melanogaster
Sequence 2:NP_002194.2 Gene:ITGA2 / 3673 HGNCID:6137 Length:1181 Species:Homo sapiens


Alignment Length:1367 Identity:295/1367 - (21%)
Similarity:479/1367 - (35%) Gaps:470/1367 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 ILIILQCVLTC---YNFNLEQRLPIVK-YGHPHS-HFGYSVATHTIGEANGPNKTNCVLVGAP-- 78
            :|.:.|.:|.|   ||..    ||..| :..|.| .|||:|.     :...| |.|.:|||:|  
Human    16 VLALSQGILNCCLAYNVG----LPEAKIFSGPSSEQFGYAVQ-----QFINP-KGNWLLVGSPWS 70

  Fly    79 -LDQNRQPNTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSN 142
             ..:||.      |.:::||:......||::      |..:. .|.|...|:|.:..:|:.:..|
Human    71 GFPENRM------GDVYKCPVDLSTATCEKL------NLQTS-TSIPNVTEMKTNMSLGLILTRN 122

  Fly   143 PLQANGSGGKVIVCAHRYMYIVRENRYGQGLCYLLTNDLQ----FEEVHEPC------------- 190
                .|:|| .:.|...:........|..|:|..::.|.|    |....:||             
Human   123 ----MGTGG-FLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSASFSPATQPCPSLIDVVVVCDES 182

  Fly   191 -----------------KGRPV------------------------------------------- 195
                             :|..:                                           
Human   183 NSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGG 247

  Fly   196 --------------------------------------------------QRQHED---YGLCQA 207
                                                              |..|::   :|:...
Human   248 DLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVL 312

  Fly   208 G--------------------------------TSAALLD------------------------- 215
            |                                ..||||:                         
Human   313 GYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQIFSIEGTVQGGDNFQME 377

  Fly   216 -------------DDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSDLNSPVDKYSYL 267
                         :|.::||:.|.:.|.|:| |.:....:|...|..:.....|.|..    |||
Human   378 MSQVGFSADYSSQNDILMLGAVGAFGWSGTI-VQKTSHGHLIFPKQAFDQILQDRNHS----SYL 437

  Fly   268 GMSVTGGRFFGHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELATADING 332
            |.||..........:.|||||:...||:|::..:.:..|.|.....|:|.||.||..|.:.|::.
Human   438 GYSVAAISTGESTHFVAGAPRANYTGQIVLYSVNENGNITVIQAHRGDQIGSYFGSVLCSVDVDK 502

  Fly   333 DHRPD-LIVAAPLYFT--KTEGGAVYVYQNIQDTLPMKYTLK---------LTGP--LE-SRFGL 382
            |...| |:|.||:|.:  |.|.|.||:           :|:|         |.||  :| :|||.
Human   503 DTITDVLLVGAPMYMSDLKKEEGRVYL-----------FTIKEGILGQHQFLEGPEGIENTRFGS 556

  Fly   383 ALANIGDLNKDNCEDLAVGAPYE--GNGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRT 445
            |:|.:.|:|.|...|:.||:|.|  .:|.||||.|....:.:|.:|||..|:  |...:  .::.
Human   557 AIAALSDINMDGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKYSQKILGSD--GAFRS--HLQY 617

  Fly   446 FGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPI--ISIQTSVQRKELHNMDPNTPGCLDDP 508
            ||.|:.|..||:.:|..||.||||..  .|.|.::.|  ::|:.|...:::..::.|....|.  
Human   618 FGRSLDGYGDLNGDSITDVSIGAFGQ--VVQLWSQSIADVAIEASFTPEKITLVNKNAQIILK-- 678

  Fly   509 ASNLTCFT--FRACCSIEPYDEKNKELRLAYSV--EAETFDHLKKFSRVF---FFDRENKRTNVL 566
                .||:  ||.       .::|.::.:.|::  :|:.|.     |||.   .|...|:|....
Human   679 ----LCFSAKFRP-------TKQNNQVAIVYNITLDADGFS-----SRVTSRGLFKENNERCLQK 727

  Fly   567 SRVVRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSALVRLNPILD-QTQAHV 630
            :.||    |....|.....||: ...|:...:..|:..||..|        ..:|.|: .::...
Human   728 NMVV----NQAQSCPEHIIYIQ-EPSDVVNSLDLRVDISLENP--------GTSPALEAYSETAK 779

  Fly   631 DFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRINVSNLADSAYEAQLFI 695
            .|...|.||||:|.||.|:|::.|. .|..:....:.:......|...:.:.|..:|||...:.:
Human   780 VFSIPFHKDCGEDGLCISDLVLDVR-QIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTGIVV 843

  Fly   696 AHQAGVSYVATKKP---TNATCN-SYNTTLVACSLGNPMLR---DTTTFVTIRFQPKGLEPSEKI 753
            .....:.:.:...|   |..||. :.:...|||.:|.|.|:   ..|..:...|..:.|: ::..
Human   844 DFSENLFFASFSLPVDGTEVTCQVAASQKSVACDVGYPALKREQQVTFTINFDFNLQNLQ-NQAS 907

  Fly   754 MLFHIFA-----NTTSKLVGPERP-ERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVAN--SVAN 810
            :.|...:     |....||..:.| ..|..:::.|...:|          ||..||..|  |:.:
Human   908 LSFQALSESQEENKADNLVNLKIPLLYDAEIHLTRSTNIN----------FYEISSDGNVPSIVH 962

  Fly   811 TAATDIEGHGPMGMDDVGSQVHHMFTI-FNEGPSTAPKVQMVIHWP-YSLYSDPQSGRPVQYLLY 873
            :            .:|||.:  .:|:: ...|........::||.| |:...:|        |:|
Human   963 S------------FEDVGPK--FIFSLKVTTGSVPVSMATVIIHIPQYTKEKNP--------LMY 1005

  Fly   874 LEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSY 938
            |..|.|.:.....|:..   :|||.:...|                              |..|:
Human  1006 LTGVQTDKAGDISCNAD---INPLKIGQTS------------------------------SSVSF 1037

  Fly   939 YSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVR 1003
            .|.:.|  |:.                                         ||:|.  ..:|..
Human  1038 KSENFR--HTK-----------------------------------------ELNCR--TASCSN 1057

  Fly  1004 IECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQI----PESYGVEVMDHNNI 1064
            :.|.:.::....|..|.|..|:||.|..|.  ..:.|::  ||.|:|    ||.|   |::.|.:
Human  1058 VTCWLKDVHMKGEYFVNVTTRIWNGTFASS--TFQTVQL--TAAAEINTYNPEIY---VIEDNTV 1115

  Fly  1065 EVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGNLEKM 1129
            .:...    :........:|..:||..|:.|:|||..:..:|||:|||||          ..|||
Human  1116 TIPLM----IMKPDEKAEVPTGVIIGSIIAGILLLLALVAILWKLGFFKR----------KYEKM 1166

  Fly  1130 NE 1131
            .:
Human  1167 TK 1168

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mewNP_001285196.1 Int_alpha 48..111 CDD:214549 20/66 (30%)
Int_alpha 317..368 CDD:214549 18/53 (34%)
Int_alpha 378..428 CDD:214549 21/51 (41%)
Int_alpha 446..491 CDD:214549 18/46 (39%)
Integrin_alpha2 479..1006 CDD:285619 106/553 (19%)
ITGA2NP_002194.2 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 34..92 21/69 (30%)
Int_alpha 47..95 CDD:214549 18/59 (31%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 101..161 15/64 (23%)
vWA_integrins_alpha_subunit 173..353 CDD:238746 9/179 (5%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 366..420 9/54 (17%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 423..475 16/55 (29%)
Int_alpha 433..475 CDD:214549 14/45 (31%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 477..539 23/72 (32%)
Int_alpha 487..>532 CDD:214549 18/55 (33%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 540..598 23/57 (40%)
Int_alpha 551..604 CDD:214549 21/52 (40%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 602..664 23/67 (34%)
Int_alpha 614..>642 CDD:214549 12/27 (44%)
Integrin_alpha2 655..1060 CDD:285619 105/547 (19%)
Interaction with HPS5 1155..1161 4/5 (80%)
GFFKR motif 1157..1161 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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