DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and ITGA1

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_852478.1	Gene:	ITGA1 / 3672	HGNCID:	6134	Length:	1179	Species:	Homo sapiens

Alignment Length:	1386	Identity:	316/1386 - (22%)
Similarity:	486/1386 - (35%)	Gaps:	477/1386 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PNCRLRQNLGI------LIILQCVLTCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNK 69
            |..|.|..:.:      .::|:|   |.:||::.:..:...|.....|||:|..:...|.
Human     3 PRPRARPGVAVACCWLLTVVLRC---CVSFNVDVKNSMTFSGPVEDMFGYTVQQYENEEG----- 59

  Fly    70 TNCVLVGAPL---DQNRQPNTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKE 131
             ..||:|:||   .:||      :|.:::||: .|.:....|..|...|     .|.|...|:||
Human    60 -KWVLIGSPLVGQPKNR------TGDVYKCPV-GRGESLPCVKLDLPVN-----TSIPNVTEVKE 111

  Fly   132 DQWMGVTVRSNPLQANGSGGKVIVCAHRYMYIVRENRYGQGLC---------------------- 174
            :...|.|:.:||      .|..:.|...|.|......|..|:|
Human   112 NMTFGSTLVTNP------NGGFLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSIAPVQECSTQ 170

  Fly   175 -------------------YLLTNDL--------------------------------------- 181
                               ....|||
Human   171 LDIVIVLDGSNSIYPWDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLV 235

  Fly   182 -----------------------------------------------------QFEEVHEPCKGR 193
                                                                 :.::|.:.|:..
Human   236 AAKKIVQRGGRQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNHRLKKVIQDCEDE 300

  Fly   194 PVQR--------------------------------QH-----EDYGL---------------CQ 206
            .:||                                :|     ::..|               ..
Human   301 NIQRFSIAILGSYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKTLGERIFALEAT 365

  Fly   207 AGTSAALLD-------------DDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSDLN 258
            |..|||..:             .|.::||:.|.|.|.|:: |.|...:.:....||:..:.:..|
Human   366 ADQSAASFEMEMSQTGFSAHYSQDWVMLGAVGAYDWNGTV-VMQKASQIIIPRNTTFNVESTKKN 429

  Fly   259 SPVDKYSYLGMSVTGG-RFFGHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFG 322
            .|:  .||||.:|... ...|.:.|.||.||....|||:|: :..|..|.:...|.|||.||.||
Human   430 EPL--ASYLGYTVNSATASSGDVLYIAGQPRYNHTGQVIIY-RMEDGNIKILQTLSGEQIGSYFG 491

  Fly   323 YELATADINGDHRPD-LIVAAPLYF--TKTEGGAVYVYQNIQDTL-------PMKYTL------- 370
            ..|.|.||:.|...| |:|.||:|.  .|.|.|.||||...|...       |:|.|.
Human   492 SILTTTDIDKDSNTDILLVGAPMYMGTEKEEQGKVYVYALNQTRFEYQMSLEPIKQTCCSSRQHN 556

  Fly   371 -----KLTGPLESRFGLALANIGDLNKDNCEDLAVGAPYEGN--GVVYIYLGSSQGLNSKPAQKI 428
                 ....|..:|||.|:|.:.|||.|...|:.:|||.|.:  |.||||.||.:.:..:.||:|
Human   557 SCTTENKNEPCGARFGTAIAAVKDLNLDGFNDIVIGAPLEDDHGGAVYIYHGSGKTIRKEYAQRI 621

  Fly   429 QASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSA-------AVILLARPIISIQ 486
            .:   ||   :|:.::.||.||.|..||:.:...||.||....:|       ||:.:.......:
Human   622 PS---GG---DGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWSRDVAVVKVTMNFEPNK 680

  Fly   487 TSVQRKELHNMDPNTPGCLDDPASNLT-CFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKKF 550
            .::|:|..| |:.....|:     |.| ||..:    ::..::...|..|.|.|   |.|.|::.
Human   681 VNIQKKNCH-MEGKETVCI-----NATVCFDVK----LKSKEDTIYEADLQYRV---TLDSLRQI 732

  Fly   551 SRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSA 615
            ||.||...:.:      :|.|..|..::||...:.|: .:..|.|..||..|.::|.:|
Human   733 SRSFFSGTQER------KVQRNITVRKSECTKHSFYM-LDKHDFQDSVRITLDFNLTDP------ 784

  Fly   616 LVRLNPILDQTQAHVDFEG-TFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLIL---DETELE 676
              ...|:||.:..:...|. .|.||||:.:.|.|:|.:.|       :..|..|::   ...:..
Human   785 --ENGPVLDDSLPNSVHEYIPFAKDCGNKEKCISDLSLHV-------ATTEKDLLIVRSQNDKFN 840

  Fly   677 VRINVSNLADSAYEAQLFIAHQAGVSYVATKKPTNATCNSYNTTLVACSLGNPMLR--DTTTFVT 739
            |.:.|.|..||||..:..:.:...:.:...:.....:|.|.:.  :.|.:|.|.||  :..|| .
Human   841 VSLTVKNTKDSAYNTRTIVHYSPNLVFSGIEAIQKDSCESNHN--ITCKVGYPFLRRGEMVTF-K 902

  Fly   740 IRFQPKGLEPSEKIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQ-----SFY 799
            |.||.......|.:.   |:.:.||   ..|.|...|..|||        ..:||.:     .||
Human   903 ILFQFNTSYLMENVT---IYLSATS---DSEEPPETLSDNVV--------NISIPVKYEVGLQFY 953

  Fly   800 SGSSV--ANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDP 862
            |.:|.  .:..||....::..    ..:|:|::::..:.|...|....|::::.|.:|    :..
Human   954 SSASEYHISIAANETVPEVIN----STEDIGNEINIFYLIRKSGSFPMPELKLSISFP----NMT 1010

  Fly   863 QSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSREN--PAYLSAPAQMRMFPSQSRH 925
            .:|.||.|                         |..|:|....|  |.....|..
Human  1011 SNGYPVLY-------------------------PTGLSSSENANCRPHIFEDPFS---------- 1040

  Fly   926 SFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIV 990
                  |:|.:...:|:   ||               |:|.|
Human  1041 ------INSGKKMTTST---DH---------------LKRGT----------------------- 1058

  Fly   991 ELDCN--KGATNCVRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPES 1053
            .||||  |.||    |.|   |:.:...:||.|...||..|.:..|        ||:....|..
Human  1059 ILDCNTCKFAT----ITC---NLTSSDISQVNVSLILWKPTFIKSY--------FSSLNLTIRG- 1107

  Fly  1054 YGVEVMDHNNIEVETRAYPELRNQQRDTSI-----------PWLIIILGIVGGLLLLALVTYVLW 1107
               |:...|...|.:.:     ||:|:.:|           |..:|:|....|||||.|:...||
Human  1108 ---ELRSENASLVLSSS-----NQKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILALW 1164

  Fly  1108 KVGFFKRIRPTDPTLSGNLEK 1128
            |:|||||      .|...:||
Human  1165 KIGFFKR------PLKKKMEK 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	17/65 (26%)
		Int_alpha	317..368	CDD:214549	24/60 (40%)
		Int_alpha	378..428	CDD:214549	23/51 (45%)
		Int_alpha	446..491	CDD:214549	14/51 (27%)
		Integrin_alpha2	479..1006	CDD:285619	118/544 (22%)
ITGA1	NP_852478.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	30..91		18/73 (25%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	101..160		16/64 (25%)
		vWA_integrins_alpha_subunit	171..351	CDD:238746	9/179 (5%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	365..417		13/52 (25%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	422..475		18/55 (33%)
		Int_alpha	434..474	CDD:214549	16/40 (40%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	476..538		27/61 (44%)
		Int_alpha	486..>529	CDD:214549	20/42 (48%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	557..615		22/57 (39%)
		Int_alpha	568..621	CDD:214549	23/52 (44%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	619..679		19/65 (29%)
		Integrin_alpha2	664..1056	CDD:285619	110/510 (22%)
		GFFKR motif	1167..1171		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142034
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740