Protein Alignment mew and scb

DIOPT Version :9

• Sequence 1: NP_001285196.1
• Gene: mew / 32275
• FlyBaseID: FBgn0004456
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Alignment Length: 1209
• Identity: 295/1209 - (24%)
• Similarity: 506/1209 - (41%)
• Gaps: 268/1209 - (22%)

  Fly    50 SHFGYSVATHTIGEANGPNKTNCVLVGAP-----LDQNRQPNTTHSGALWRCPMTQRFDDCEQVI 109
            |:|||::..          :...::||||     |:..|..|.|  ||::||.:|...  |...:
  Fly    51 SYFGYTLVI----------RQTSIIVGAPRAQSTLESQRTINET--GAIYRCSLTNGV--CSPYV 101

  Fly   110 TDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQANGSGG-----KVIVCAHRYMYIVRENRY 169
            .|.|.|.|:.......:.|.|:.||:|.::         .||     |::|||.|:......:.:
  Fly   102 LDSRGNVDAPYSEYTFDSERKDFQWLGGSM---------DGGTKDTDKLLVCAPRFYAPSSRDNH 157

  Fly   170 GQGLCYLLTNDLQFEEVH----EPCKGRPVQRQHEDYG--------LCQAGTSAALLDDDT-MVL 221
            ..|:||.:.|.:.....|    .|.:.:..|.:.||.|        :.:.|.||.:.||:| .::
  Fly   158 LHGVCYWVNNTVASTPQHVTRISPLRLKSEQVKEEDNGNKASFFYIMGELGLSAHVADDNTKFLI 222

  Fly   222 GSPGPYTWRGSIWVTQ------------------VGGEYLQRDKTTYYSDHSDLNSPV------D 262
            |:||..|||||:.:.:                  :...|...|...|..:|.....|.      :
  Fly   223 GAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQE 287

  Fly   263 KYSYLGMSVTGGRFFG-----HMSYAAGAPR-SEGHGQVVIFD---KSTDNPIPVHSILDGEQFG 318
            :.||.|.:|:.| ||.     .:.|.|.||: ::..|:..|||   ||    |..:.:..|||||
  Fly   288 EDSYFGYAVSSG-FFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKS----IHKYHVFRGEQFG 347

  Fly   319 SSFGYELATADINGDHRPDLIVAAPLYFTKT--EGGAVYVYQNIQDTLPMKYTLKLTGPLE--SR 379
            ..|||.:...|:|||.:.|:||:||.:..:.  :.||:||:.| :.....:..: |..|:|  :|
  Fly   348 EYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFIN-KGFFNFERQI-LRSPVETMAR 410

  Fly   380 FGLALANIGDLNKDNCEDLAVGAPYEGNGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIR 444
            ||.||:.:||:|.|...|:|||||:.|||.|:|||||..||..:|:|::.|       |:.||.:
  Fly   411 FGTALSRLGDINHDGYNDVAVGAPFAGNGTVFIYLGSENGLRDQPSQRLDA-------PSQQPSK 468

  Fly   445 ----TFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPNTPGCL 505
                .||..:|..:|:|.|.:.|..|||.|:.|..:..|.|::.:..:| :.|...:.|.
  Fly   469 YGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATV-KSESREIKPE----- 527

  Fly   506 DDPASNLTCFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKKFSRVFFFDRENKRTNVLSRVV 570
            .:......|:......:.:...|:...:|:|..         |:..||.|   ...:||.:|  .
  Fly   528 QEKVKITACYRLSTTSTDKLVQEQELAIRIAMD---------KQLKRVKF---TQTQTNEIS--F 578

  Fly   571 RVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSALVRLNPILDQTQAHVDFEG- 634
            :|:.|...:|:.....::.:.:||.||:...:.|.|.:.............|:|.|:..|..:.
  Fly   579 KVNANFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQNI 643

  Fly   635 TFQKDCGDDDLCESNLIIR---VEPNITESSGNEYTLILDETE-LEVRINVSNLADSAYEAQLFI 695
            .|...|. .|:|.::|.:|   |.|          |.||...: |.:...::|:.::||..|..:
  Fly   644 IFSTGCA-TDVCTADLQLRSKDVSP----------TYILGSADTLRLNYEITNIGETAYLPQFNV 697

  Fly   696 AHQAGVSYVATKKPTNATCNSYNTTLVACSL--GNPMLRDTTTFVTIRFQPKGLEPSEKIMLFHI 758
            ...:.:::  .:.|.|  |...:..:| |.|  |.|:.:..|..|||.|....|.....|:...:
  Fly   698 TSTSRLAF--AQVPGN--CKVVDAVMV-CDLNRGRPLAKGDTDSVTISFDVSQLSGQSLIIHAEV 757

  Fly   759 FANTTSKLVGPER-PERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGPM 822
            |:      .|.|: |..:.:.||:...:..        :...||....:.:      |:|.:..
  Fly   758 FS------TGYEQNPTDNRQTNVIGLKEFT--------EIDASGGQTNSQI------DLEHYSN- 801

  Fly   823 GMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYL---------LYLEQVP 878
                 .:::.:.:.|.:.|||...::.:..:.|.: |....|...:..:         .|..|:.
  Fly   802 -----SAEIVNNYEIKSNGPSVIEQLTVSFYIPIA-YKVAGSTAIIPIINVTSLKMQASYDSQLL 860

  Fly   879 TVEV-SQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSS 942
            :::: .|....:..:.|......||..|           |...:|:|.|::   ||:....:.:.
  Fly   861 SIDLYDQNNTMLVVDPVEVTTTLSGGLE-----------RTVITQNRQSYD---IHTSGHVHQTM 911

  Fly   943 HRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKG---------- 997
            ...|.|....::.:|.||. |:.:| ..|..|    :..:|.|..|::. |..||
  Fly   912 EVLDTSMVATASMSRKRRD-LKALT-ANREQY----ARISNVKAHDLLS-DDFKGKLPVNRTIVF 969

  Fly   998 ------ATNCVRIECDI---------LNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTAT 1047
                  .|.|||.|..:         |||....:...|      |:.||.
  Fly   970 NCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEV------NAILVD--------------- 1013

  Fly  1048 AQIPESYGVEVMD----------HNNIEVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALV 1102
               |..|.|.:.|          ..:..:..|..|.:.::.::|.:|..|||:.::||||||:.:
  Fly  1014 ---PWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAI 1075

  Fly  1103 TYVLWKVGFFKRIRPTDPTLSGNLEKMNEEKPFLAPSKN 1141
            :|:|:|.|||.|      |....|:::.::.|....::|
  Fly  1076 SYLLYKFGFFNR------TKKDELDRLVQQNPVEPEAEN 1108

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	18/65 (28%)
		Int_alpha	317..368	CDD:214549	19/52 (37%)
		Int_alpha	378..428	CDD:214549	28/49 (57%)
		Int_alpha	446..491	CDD:214549	15/44 (34%)
		Integrin_alpha2	479..1006	CDD:285619	109/560 (19%)
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	18/65 (28%)
		FG-GAP	350..388	CDD:280083	15/37 (41%)
		Int_alpha	409..459	CDD:214549	28/49 (57%)
		Int_alpha	473..>515	CDD:214549	14/41 (34%)
		Integrin_alpha2	507..829	CDD:285619	74/383 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439840
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12256at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850