DRSC/TRiP Functional Genomics Resources

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Protein Alignment mew and ITGA6

DIOPT Version :10

Sequence 1:NP_001285196.1 Gene:mew / 32275 FlyBaseID:FBgn0004456 Length:1243 Species:Drosophila melanogaster
Sequence 2:NP_001381857.1 Gene:ITGA6 / 3655 HGNCID:6142 Length:1130 Species:Homo sapiens


Alignment Length:1298 Identity:361/1298 - (27%)
Similarity:564/1298 - (43%) Gaps:336/1298 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 CRLRQNLGILIILQCVLTCYNFNLEQRLP--IVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLV 75
            |.|..:.|:|..|...     |||:.|..  |.|||.|.|.||:|:|.|...:   |.....:||
Human     8 CLLYLSAGLLSRLGAA-----FNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQ---PEDKRLLLV 64

  Fly    76 GAPLDQN---RQPNTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGV 137
            |||..:.   ::.|.|  |.|:.|.:|.| ..|.::      .||::  :.| ..|.||||||||
Human    65 GAPRAEALPLQRANRT--GGLYSCDITAR-GPCTRI------EFDND--ADP-TSESKEDQWMGV 117

  Fly   138 TVRSNPLQANGSGGKVIVCAHRY-----MYIVRENRYGQGLCYLLTNDLQFEEVHEP-----CKG 192
            ||     |:.|.||||:.|||||     :...:|:|...|.||:|:.:|:.|:..:.     |.|
Human   118 TV-----QSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDG 177

  Fly   193 RPVQRQHEDYGLCQAGTSAALLDD-DTMVLGSPGPYTWRGSIWVTQ-----------------VG 239
            |  .|.||.:|.||.|.:|....| ..:|.|:||.|.|:|.:.|.|                 ||
Human   178 R--LRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVG 240

  Fly   240 GE-------------------------YLQRDKTTYYS----DHSDLNSPVDKYSYLGMSVTGGR 275
            ||                         |...|:..|.:    :..|....|...||||.|:..|:
Human   241 GETEHDESLVPVPANSYLGLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLDSGK 305

  Fly   276 FF---GHMSYAAGAPRSEGHGQVVIF--DKSTDNPIPVHSILDGEQFGSSFGYELATADINGDHR 335
            ..   ..:::.:||||:...|.||:.  |..:.:.:|.| |.|||...|||||::|..|:|.|..
Human   306 GIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEH-IFDGEGLASSFGYDVAVVDLNKDGW 369

  Fly   336 PDLIVAAPLYFTK--TEGGAVYVYQNIQDTLPMKYTLKLTGPLESRFGLALANIGDLNKDNCEDL 398
            .|:::.||.||.:  ..|||||||.|.|........::|.|..:|.||:|:.||||:|:|...|:
Human   370 QDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDI 434

  Fly   399 AVGAPYEGNGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYPD 463
            ||||||:..|.|:||.||:.|:|:||.|.::     |..|      .||.||:||.|||.|||||
Human   435 AVGAPYDDLGKVFIYHGSANGINTKPTQVLK-----GISP------YFGYSIAGNMDLDRNSYPD 488

  Fly   464 VVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPN-----------TPG--CLDDPASNLTCF 515
            |.:|:. |.:..|..:||:|:||.::      .:.||           .|.  ||...    :||
Human   489 VAVGSL-SDSVTIFRSRPVINIQKTI------TVTPNRIDLRQKTACGAPSGICLQVK----SCF 542

  Fly   516 TFRACCSIEP--YDEKNKELRLAYSVEAETFDHLKKFSRVFFFDRENKRTNVLSRV--------- 569
            .:.|    .|  |   |..:.:..::|||               :|.:::.:.|||         
Human   543 EYTA----NPAGY---NPSISIVGTLEAE---------------KERRKSGLSSRVQFRNQGSEP 585

  Fly   570 -----VRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSALVRLN------PIL 623
                 :.:....:..|...|.:::.|.||...|:.......:.||    |:..|:|      |||
Human   586 KYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEP----SSRRRVNSLPEVLPIL 646

  Fly   624 DQTQ---AHVDFEGTFQKD-CGDDDLCESNLIIRVEPNITESSGNE-------------YTLILD 671
            :..:   ||:|..  |.|: ||||::|.|||  ::|.......||:             ..::.|
Human   647 NSDEPKTAHIDVH--FLKEGCGDDNVCNSNL--KLEYKFCTREGNQDKFSYLPIQKGVPELVLKD 707

  Fly   672 ETELEVRINVSNL----------ADSAYEAQLFIAHQAGVSYVA-------TKKPTNATCNSYNT 719
            :.::.:.|.|:|.          .|.|:||:|.......::|.|       .:|..:...|. |.
Human   708 QKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQ-NG 771

  Fly   720 TLVACSLGNPMLRD---------TTTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERPERD 775
            :...|.||||..|:         :||.||  |....|:.:.|:       .|||        .:|
Human   772 SQADCELGNPFKRNSNVTFYLVLSTTEVT--FDTPDLDINLKL-------ETTS--------NQD 819

  Fly   776 LRVNVVRRAK------LNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHM 834
            ....:..:||      |:..|.|.|.|.::.|:.|......:.            |:|||.:.:.
Human   820 NLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSE------------DEVGSLIEYE 872

  Fly   835 FTIFNEG-PST-APKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPL 897
            |.:.|.| |.| .....:.|.||..:    .:|:   :||||.:|.:..:.:..|...|| :|.|
Human   873 FRVINLGKPLTNLGTATLNIQWPKEI----SNGK---WLLYLVKVESKGLEKVTCEPQKE-INSL 929

  Fly   898 NLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSF 962
            ||                                                   |:|:.:|.:|..
Human   930 NL---------------------------------------------------TESHNSRKKREI 943

  Fly   963 LERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNMPALSEAQVVVKARLWN 1027
            .|:     ::..:.:.|..|..|.|   .|:|:.. .|||.|.|.:..:.  |:|.:::::||||
Human   944 TEK-----QIDDNRKFSLFAERKYQ---TLNCSVN-VNCVNIRCPLRGLD--SKASLILRSRLWN 997

  Fly  1028 STLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYPELRNQQRDTSIPWLIIILGI 1092
            ||.:.||.::..:.|...|...:..:.....:.:...:|....:|. :...:.:.:||.||::.|
Human   998 STFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPS-KTVAQYSGVPWWIILVAI 1061

  Fly  1093 VGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGNLEKMNEEKPFLAPSKNTHHVFXQEGTVGWD 1155
            :.|:|:|||:.::|||.|||||.|..|.....:..::.:|:..:...|...::. ::....|:
Human  1062 LAGILMLALLVFILWKCGFFKRSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKKQWITKWN 1124

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mewNP_001285196.1 Int_alpha 48..111 CDD:214549 21/65 (32%)
Int_alpha 317..368 CDD:214549 23/52 (44%)
Int_alpha 378..428 CDD:214549 28/49 (57%)
Int_alpha 446..491 CDD:214549 23/44 (52%)
Integrin_alpha2 480..1006 CDD:462478 133/611 (22%)
ITGA6NP_001381857.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 30..95 24/70 (34%)
Int_alpha 40..100 CDD:214549 21/71 (30%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 101..166 31/72 (43%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 176..229 20/54 (37%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 283..339 16/55 (29%)
Int_alpha 293..345 CDD:214549 16/52 (31%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 340..402 29/62 (47%)
Int_alpha 353..406 CDD:214549 23/52 (44%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 403..458 26/54 (48%)
Int_alpha 413..464 CDD:214549 28/50 (56%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 459..518 28/76 (37%)
Int_alpha 470..>493 CDD:214549 15/22 (68%)
Integrin_alpha2 504..978 CDD:462478 133/611 (22%)
Interaction with HPS5 1077..1083 4/5 (80%)
GFFKR motif 1079..1083 3/3 (100%)

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