DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itga8

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001167443.1	Gene:	Itga8 / 364786	RGDID:	621634	Length:	1062	Species:	Rattus norvegicus

Alignment Length:	1198	Identity:	327/1198 - (27%)
Similarity:	515/1198 - (42%)	Gaps:	221/1198 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PFTTIRPNCRLRQNLGILIILQCVLTCYNFNLEQRLPIVKYGHPH-SHFGYSVATHTIGEANGPN 68
            ||..:   |.:...||:|  ...|...:|.::::   :..|..|. |:||||:..: |.:|
  Rat    16 PFACL---CCVSAVLGML--WSPVSLAFNLDVDK---LTVYSGPEGSYFGYSLDFY-IPDA---- 67

  Fly    69 KTNCVLVGAPLDQNRQPNTTHSGALWRCPM-TQRFDDCEQVITDGRRNFDSEILSPPGNDEIKED 132
            :|..||||||.....||:....||::.||. .:|...|:|:..|...|....:.......|.|.:
  Rat    68 RTASVLVGAPKANTSQPDIVEGGAVYYCPWPAERSAQCKQIPFDTTNNRKIRVNGTKEPIEFKSN 132

  Fly   133 QWMGVTVRSNPLQANGSGGKVIVCAHRYMY-IVREN--RYGQGLCYLLTNDLQFEEVHEPCKGRP 194
            ||.|.|||::.       |||:.||..|.: .::.|  :...|.||:...:......|.||:...
  Rat   133 QWFGATVRAHK-------GKVVACAPLYHWRTLKPNPAKDPVGTCYVAIQNFSAYAEHSPCRNSN 190

  Fly   195 VQRQHEDYGLCQAGTSAALLDDDTMVLGSPGPYTWRG---SIWVTQVGGEY--------LQRDKT 248
            |  ..|..|.||||.|.....:..:::|.||.:.|:|   ::.|..:...|        |..:|.
  Rat   191 V--DPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITVSVADIIANYSFKDILRKLAAEKQ 253

  Fly   249 T-----YYSDHSDLNSPVDKYSYLGMSVTGGRFFGH--MSYAAGAPR-SEGHGQVVIFDKSTDNP 305
            |     .|.|           ||||.||..|.|.|.  ....||.|| ::..|.|.|.: |||
  Rat   254 TDVAPASYDD-----------SYLGYSVAAGEFTGDSLQELVAGIPRGAQNFGYVSIIN-STD-- 304

  Fly   306 IPVHSILDGEQFGSSFGYELATADINGDHRPDLIVAAPLYFTK------TEGGAVYVYQNIQDTL 364
            :.......|||..|.|||.:..:|:|.|...|::|.|||:..:      .|.|.||:|..: ..|
  Rat   305 MTFIQNFTGEQMASYFGYTVVVSDVNNDGMDDILVGAPLFMEREFESNPREVGQVYLYLQV-SAL 368

  Fly   365 PMKYTLKLTG-PLESRFGLALANIGDLNKDNCEDLAVGAPYEG---NGVVYIYLGSSQGLNSKPA 425
            ..:....||| ....|||.::|::||||:|...|:|:|.|:.|   .|.|.||.|:::||:|||:
  Rat   369 LFQDPQVLTGTETFGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNARGLHSKPS 433

  Fly   426 QKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQ 490
            |.:|......|||:|     ||.|:.|:.|:|.|.|||:::|||......:..|||::::...:.
  Rat   434 QVLQGIWGSQTIPSG-----FGFSLRGDADIDKNDYPDLLVGAFGEGKVAVYRARPVVTVDAQLL 493

  Fly   491 RKELH----NMDPNTPGCLDDPASNLTCFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKK-- 549
               ||    |::..|....:.| :.:.||:.|.|.||......|   .:|...|.: .|.||:
  Rat   494 ---LHPMIINLENKTCQIPEFP-TPVACFSLRVCASIAGQSISN---TVALMAEVQ-LDFLKQKG 550

  Fly   550 -FSRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANT--RDIQTPVRFRLKYSLVEPPL 611
             ..|..|.  .|.:::::...| :.......||....|::..|  ||..:|:...|.|||.:...
  Rat   551 AIKRTLFL--HNHQSHLIFPFV-MRQQKSLHCQDFMVYLRDETEFRDKLSPINVSLNYSLDDSTF 612

  Fly   612 ADSALVRLNPILDQ-------TQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLI 669
            .|.  :.:.|||:.       .|||:      ..|||:|:||..:|.:...|:..|      .:|
  Rat   613 EDG--LEVKPILNHYRENVVTEQAHI------LVDCGEDNLCVPDLRLSARPDKQE------III 663

  Fly   670 LDETELEVRINVSNLADSAYEAQLFIAHQAGVSYVATKKPTNA----TCNSYN----TTLVACSL 726
            .||..|.:.||..|..:.||||:||:.......||..::....    :| .|.    |.:|.|.|
  Rat   664 GDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGLRLLSC-EYKMENVTRMVVCDL 727

  Fly   727 GNPMLRDTTTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERPERD---LRVNVVRRAKLNF 788
            ||||:..|...:.:||....||.:...:.|.:...:::|    :.|:.:   :::||...|::..
  Rat   728 GNPMVTGTNFSLGLRFAVPRLEKTNMSINFDLQIRSSNK----DNPDSNFVSVQINVTAVAQVEI 788

  Fly   789 RGWAIPEQSFYSGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIH 853
            ||.:.|.|       :...:.|....:    .|...::||..|.|::.:.|.||||.....:.:.
  Rat   789 RGVSHPPQ-------IVLPIHNWEPAE----EPHKEEEVGPLVEHIYELHNIGPSTISDSILEVG 842

  Fly   854 WPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRM 918
            ||:|...        ::|||:..:.|              :.||...:....||..:...|....
  Rat   843 WPFSARE--------EFLLYVFHLQT--------------LGPLQCQTNPEINPQDIKPAASPED 885

  Fly   919 FPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAAN 983
            .|..|....|.::.|..|.      ||..                         :..|...:.|.
  Rat   886 TPELSAFLRNATIPHLVRK------RDVP-------------------------VVQPHRQSPAK 919

  Fly   984 GKKQDIVELDCNKGATNCVRIECDILNMPALSEAQVVVKARLWNSTLVSE----YPRVERVRIFS 1044
                   .|:|..  .:|::|.|.:..:.....|.:.|::|||..|.:..    |.....|   |
  Rat   920 -------ILNCTN--IDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLQRKNDPYALASLV---S 972

  Fly  1045 TATAQIPESYGVEVMDHNNIEVETR---AYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVL 1106
            ....:||.......:...:..::|.   |.|.:     ..|||..:|||.|:.|||:||::|..|
  Rat   973 FEVKKIPYKEQPAKLPAGSTAIKTSVIWATPNV-----SFSIPLWVIILAILLGLLVLAILTLAL 1032

  Fly  1107 WKVGFFKRIRPTDPTLSGNLEKMNEEKP 1134
            ||.|||.|.||....::...:..:::.|
  Rat  1033 WKCGFFDRARPPQDEMTDREQLTSDKTP 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	24/64 (38%)
		Int_alpha	317..368	CDD:214549	18/56 (32%)
		Int_alpha	378..428	CDD:214549	25/52 (48%)
		Int_alpha	446..491	CDD:214549	16/44 (36%)
		Integrin_alpha2	479..1006	CDD:285619	127/553 (23%)
Itga8	NP_001167443.1	Int_alpha	53..111	CDD:214549	23/62 (37%)
		Int_alpha	316..>364	CDD:214549	17/47 (36%)
		Int_alpha	382..436	CDD:214549	25/53 (47%)
		Int_alpha	447..491	CDD:214549	17/48 (35%)
		Integrin_alpha2	482..933	CDD:285619	127/553 (23%)
		Integrin_alpha	1034..1048	CDD:278771	7/13 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I10920
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820