Protein Alignment mew and Itga3

DIOPT Version :10

• Sequence 1: NP_001285196.1
• Gene: mew / 32275
• FlyBaseID: FBgn0004456
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: NP_001359143.1
• Gene: Itga3 / 360606
• RGDID: 1310333
• Length: 1067
• Species: Rattus norvegicus
• Alignment Length: 1163
• Identity: 340/1163 - (29%)
• Similarity: 518/1163 - (44%)
• Gaps: 240/1163 - (20%)

  Fly    32 YNFNLEQRLPIVKYG-HPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNRQPN-TTHSGALW 94
            :.|||:.:..:||.. :|.|.||||||.|...|.   .:...:|.|||.|.....: |..:||::
  Rat    31 FAFNLDTKFLVVKEAVNPGSLFGYSVALHRQTER---QQRYLLLAGAPRDLAVDDDYTNRTGAVY 92

  Fly    95 RCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQANGSGGKVIVCAHR 159
            .||:|...:|||::....:.:.|..|:         ||.|:||||.|     .|..|:|:|||||
  Rat    93 LCPLTALKNDCERMDISEKSDPDHHII---------EDMWLGVTVAS-----QGPAGRVLVCAHR 143

  Fly   160 YMYI----VRENRYGQGLCYLLTNDLQFEEVHEPCKGRPVQRQHE-------DY---GLCQAGTS 210
            |..:    :.:.|...|.||:..||||.:      .|...|..|.       ||   |:||.|||
  Rat   144 YTKVLWSGLEDQRRMVGKCYVRGNDLQLD------PGDDWQTYHNEMCNSNTDYLQTGMCQLGTS 202

  Fly   211 AALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSDLNSPVDKYSYLGMSVTGGR 275
            .. ...:|:..|:||.|.|:|:.::.|      ::|        .||:    :|||.|....|..
  Rat   203 GG-FTQNTVYFGAPGAYNWKGNSYMIQ------RKD--------WDLS----EYSYRGSEDQGNL 248

  Fly   276 FFGH-------------MSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELAT 327
            :.|:             ::...||||.:..|.|.:..:.:...:....:|.|.|.|:.||..:|.
  Rat   249 YIGYTMQVGSAILHPSEITLVTGAPRHQHMGAVFLLKQESGGDLQRRQVLKGTQVGAYFGSAIAL 313

  Fly   328 ADINGDHRPDLIVAAPLYFTKTE--GGAVYVYQNIQDT-LPMKYTLKLTGPLESRFGLALANIGD 389
            ||:|.|...||:|.||.||.:.|  ||||||:.|...| .|.:.:|.|.||..|.||:::|:|||
  Rat   314 ADLNNDGWQDLLVGAPYYFERKEEVGGAVYVFMNQAGTSFPDQPSLLLHGPSRSAFGISVASIGD 378

  Fly   390 LNKDNCEDLAVGAPYEGNGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISISGNT 454
            :|:|..:|:|||||:||.|.||||..||.||..:|.|.|....||  :|.   :.|||.|:||..
  Rat   379 INQDGFQDIAVGAPFEGLGKVYIYHSSSGGLLKQPQQIIHGETLG--LPG---LATFGYSLSGKM 438

  Fly   455 DLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPNTPGCLDDPASNLT------ 513
            |:|:|.|||:::|:. |...|:|.|||:|:|        ||......|..||.....:|
  Rat   439 DVDENLYPDLLVGSL-SDHIVLLRARPVINI--------LHRTLVARPAVLDPSLCTVTSCVQVE 494

  Fly   514 -CFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKKFSRVFFFDRENKRTNVLSRVVRVHTN-- 575
             ||.:........|   .:.:.|||:|||               ||:.:...:  |..|..::
  Rat   495 LCFAYNQSAGNPNY---RRNITLAYTVEA---------------DRDRRPPRL--RFARSQSSVF 539

  Fly   576 ------GRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSALVRLN-------PILDQTQ 627
                  ..|.||.:...:..|.||...|:...:.|||   ||.....::|.       |:|:|.|
  Rat   540 HGFFSMPETHCQTLELLLMDNVRDKLRPIVITMNYSL---PLRMPDRLKLGLRSLDAYPVLNQAQ 601

  Fly   628 A---HVDFEGTFQKDCGDDDLCESNLIIR---VEPNITESSGNEYTLILDETELEVRINVSN--- 683
            |   |.:..  |||:||.|:.|:|||.:|   |...:...|..:|:  .|..:|.:.|||:|
  Rat   602 AMENHTEVH--FQKECGPDNKCDSNLQMRAAFVSEQLQPLSRLQYS--RDTKKLFLSINVTNSPS 662

  Fly   684 ---LADSAYEAQLFIAHQAGVSYVATKKPTNATCNSYNTTLVACSLGNPMLRDTTTFVTIRFQPK 745
               ..:.|:||.|.:...:.: .:::.:|. .||.: |.|...|.||||..|:....:.|.|:..
  Rat   663 RQRAGEDAHEALLTLEVSSAL-LLSSVRPA-GTCQA-NETNTVCELGNPFKRNQRMELLIAFEVT 724

  Fly   746 GLEPSEKIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVAN 810
            |:....:.:..|:..:|:|.....:.....|:|:...:|.|:.....:  |||:||:.:..:...
  Rat   725 GVTLHTRDLRAHLQLSTSSHQDNLQPMFLTLQVDYTLQASLSLMNHRL--QSFFSGTVMGEAAMK 787

  Fly   811 TAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMV--IHWPYSLYSDPQSGRPVQYLLY 873
            |            :.||||.:.:.|.:...|...|....:|  :.|||.:.:.       ::|||
  Rat   788 T------------VKDVGSPLKYEFQVSPVGDGLAALGTLVLGLEWPYEVTNG-------KWLLY 833

  Fly   874 LEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSY 938
            ..::.........|......||||||.         ||.|....:.|.:.|...
  Rat   834 PTEITIHSNGSWPCQPHGNLVNPLNLT---------LSDPGVKPLSPQRRRRQL----------- 878

  Fly   939 YSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVR 1003
                  |...|...                      .|.:..||...|.:.| |.|:.|...||.
  Rat   879 ------DPGGDQGP----------------------PPVTLAAAKKAKSETV-LTCSNGRARCVW 914

  Fly  1004 IECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDHN----NI 1064
            :||.:.:  |.:...|.||||:||||.:.:|...:|||:...||..:..|.....|::.    ::
  Rat   915 LECPLPD--ASNITNVTVKARVWNSTFIEDYKDFDRVRVDGWATLFLRTSIPTINMENKTTWFSV 977

  Fly  1065 EVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFK-----RIRP 1117
            ::::....||     ...|...::::.:..|||||.|:..:|||..|||     ||.|
  Rat   978 DIDSELVEEL-----PAEIELWLVLVAVGAGLLLLGLIIILLWKCDFFKPTRYYRIMP 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	24/63 (38%)
		Int_alpha	317..368	CDD:214549	25/53 (47%)
		Int_alpha	378..428	CDD:214549	28/49 (57%)
		Int_alpha	446..491	CDD:214549	20/44 (45%)
		Integrin_alpha2	480..1006	CDD:462478	131/561 (23%)
Itga3	NP_001359143.1	Int_alpha	48..108	CDD:214549	24/62 (39%)
		Int_alpha	304..352	CDD:214549	23/47 (49%)
		Int_alpha	367..417	CDD:214549	28/49 (57%)
		Integrin_alpha2	463..917	CDD:462478	131/561 (23%)