DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and if

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster

Alignment Length:	1482	Identity:	352/1482 - (23%)
Similarity:	573/1482 - (38%)	Gaps:	469/1482 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LIILQCVLTCYNFNLEQRLP-IVKYGH-PHSHFGYSVATHTIGEANGPNKTN-CVLVGAP-LDQN 82
            ||:|...::.:.:|::  || .|::.. .:|.||:|:|.|........|:.| .::|||| .|.:
  Fly    20 LILLLIAMSAHGYNID--LPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTS 82

  Fly    83 R-QPNTTHSGALWRCPMTQRFDDCEQVITDGR---RNFDSEILSPPGNDEIKEDQWMGVTVRSNP 143
            | |...|.:|.:::|.:..  |||:.|..|.:   ||.|.|::      :.|..||:|.||
  Fly    83 RYQQGVTEAGGVFKCSLND--DDCKLVPFDSKGNNRNVDKEVV------DRKSYQWLGATV---- 135

  Fly   144 LQANGSGGKVIV-CAHRYMYIV----RENRYGQ-GLCYLLTNDLQFEEVHE--PCKGR--PVQRQ 198
              |.|....::| ||.||::..    |..|... |.|:...|   |||.:|  ||:..  ...||
  Fly   136 --ATGRDSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTSHN---FEEFYEVSPCRTNNWGYHRQ 195

  Fly   199 HEDYGLCQAGTSAALLDDDT-MVLGSPGPYTWRGSIWVTQVGGEY------LQRDKTTYYSDHSD 256
                |.||||.|||:..:.: :.:|:||.:.|:|..:......::      .|...|...:...|
  Fly   196 ----GSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHD 256

  Fly   257 LNSP------------VDKYSYLGMSVTGGRFFGHMS--YAAGAPRSEGH--GQVVIFDKSTDNP 305
            :..|            |:..||||.|:..|.|.|..|  .|.|.||. |:  |::|:   :..|.
  Fly   257 VTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRG-GNLVGRIVV---NRWNM 317

  Fly   306 IPVHSILDGEQFGSSFGYELATADINGDHRPDLIVAAPLYFT------KTEGGAVYVY------- 357
            ..:.:| .|.|.|..|||.|||:|::||...||::.||:|..      |.:.|.||:.
  Fly   318 ANIFNI-TGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTE 381

  Fly   358 ------QNIQDTLPMKYTLKLTGPLESRFGLALANIGDLNKDNCEDLAVGAPY---EGNGVVYIY 413
                  ::|:|....|          .||||||..:||:|.|...|.||||||   ||.|||||:
  Fly   382 EKRWTTEHIRDGYHSK----------GRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIF 436

  Fly   414 LGSSQGLNSKPAQKIQASEL--GGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVI 476
            .||..|..:||:|.|::.:|  |...|     ||||.::||..|:|.|:|||:.:||::|....|
  Fly   437 HGSPMGPLAKPSQIIKSEQLVEGAPYP-----RTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFI 496

  Fly   477 LLARPI--ISIQTS-VQRKELHNMDPNTPGCLDDPASNLTCFTFRACCSIE-PYDEKNKELRLAY 537
            ..:||:  ::.:|| ....:|.::|..:...:.| ...:.|.....|.|.. .|..:..:..:::
  Fly   497 FKSRPVAAVNAETSFASNSKLISLDDRSCQLVRD-HKKVPCMLLTTCWSYTGRYLPEQLDFDVSW 560

  Fly   538 SVEAETFDHLKKF--SRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANTRDIQTPVRF 600
            .::|      ||.  .|:||...|.|  |:.::.:|:: .|:..|...|.|:....:|..||:..
  Fly   561 LLDA------KKLLNPRMFFLRDEGK--NIRNQTIRLN-YGQKYCLNETVYLLDKVQDKLTPLEV 616

  Fly   601 RLKYSL-VEPPLADSALVR-----LNPILDQTQAHVDFEG-TFQKDCGDDDLCESNLIIRVEPNI 658
            ..:|:| ...||  ..:||     |.|::||.:..|..:. ..||:||.|::||.:|.::|
  Fly   617 EARYNLRSSRPL--DPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKV---- 675

  Fly   659 TESSGNEYTLILDETELEVRINVSNLADSAYEAQLFIAHQAGVSY-----VATKKPTNATCN--- 715
              |:.::| |......|.:.:.:||..:.|:||..::.....:.:     :..||.|..||:
  Fly   676 --STVDKY-LFGSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPT 737

  Fly   716 SYNTTLVACSLGNPMLRDTTTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERP--ERDLRV 778
            ..|...:.|.:|||:.........|...|:....|.....|:..||:|:.    |:|  |.|
  Fly   738 PENNHTLKCDIGNPLESGKIAHFKISLVPEEKYGSSSSYDFYWEANSTNL----EKPGSEYD--- 795

  Fly   779 NVVRRA-------KLNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHMFT 836
            |.:|::       .|:.:|.::|:...|..... ..:.|....          ||:|.||.|::.
  Fly   796 NKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDY-KELENATKE----------DDIGPQVVHIYE 849

  Fly   837 IFNEGPSTAPKVQMVIHWPYS---------LYSDPQSGRPVQ--------YLLYLEQVPT----- 879
            |.|..||...:.::.||.||.         |.:.|::|..:|        |.|.|::...
  Fly   850 IRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLDEKLVKKSYL 914

  Fly   880 ----------------------------VEVSQGECHV----------AKEYVNPLNL------- 899
                                        :|.::||..|          |.:.::|..:
  Fly   915 QAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPKQVEQRRQED 979

  Fly   900 --------------------------------------ASGSRENPAYL---------------- 910
                                                  :|||....|.|
  Fly   980 TLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQLRGHSTQGHIQMAGPVQ 1044

  Fly   911 ----SAPAQMRMFPSQ-----------------------------------------------SR 924
                |:.:..|.:|:|                                               :|
  Fly  1045 HTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQFGGRNNNFHTGTLDLGTLNR 1109

  Fly   925 HSFNKSLIHSQRSYYSSS----------------------------------------------- 942
            .:.:..|..||..|.:.|
  Fly  1110 GNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQARNPGFQGQTSYQGQTQYS 1174

  Fly   943 --------HRDDHSDDTQSNRNRVRRSF-----LERVT-----------------RLERLMYDPE 977
                    |...:|..::....|....|     |::.|                 ||.|
  Fly  1175 GQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSSSSSSSSGTRRLRR------ 1233

  Fly   978 SSNAANGKKQDIVELDCNK--GATNCVRIECDILNMPAL--SEAQVVVKARLWNST---LVSEYP 1035
             ||..:|..:..:::|.|.  .:..|..|.|.:.|:...  ..|.|.::||:...|   |.|..|
  Fly  1234 -SNDKDGATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDGDAAFVAIRARMVAKTMEKLASNVP 1297

  Fly  1036 RVERVRIFSTATAQI--------PESYGVEVMDHNNIEVETRAYPELRNQQRDTSIPWLIIILGI 1092
                :.:.:.|.|.:        |:.  ..|..|   |:..:|.||  ..|....:|..:::|..
  Fly  1298 ----LNVSTLAVANVTLLPFIGAPKD--AIVKTH---EIFYKAEPE--PLQVPDVVPLWVVVLAA 1351

  Fly  1093 VGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGNLEKMNEEKPFLAPSKNTHH 1144
            ..|.|:..|:.::|:|.|||.|.||||         .::|:   .|.:|.:|
  Fly  1352 CAGALIFLLLVWLLYKCGFFNRNRPTD---------HSQER---QPLRNGYH 1391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	22/65 (34%)
		Int_alpha	317..368	CDD:214549	21/69 (30%)
		Int_alpha	378..428	CDD:214549	30/52 (58%)
		Int_alpha	446..491	CDD:214549	18/47 (38%)
		Integrin_alpha2	479..1006	CDD:285619	143/807 (18%)
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	22/65 (34%)
		Int_alpha	275..>316	CDD:214549	16/44 (36%)
		Int_alpha	398..451	CDD:214549	30/52 (58%)
		Int_alpha	466..>497	CDD:214549	13/30 (43%)
		Integrin_alpha2	499..893	CDD:285619	103/430 (24%)
		DUF2756	<1120..1178	CDD:298627	3/57 (5%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439846
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12256at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850