Protein Alignment mew and Itga11

DIOPT Version :9

• Sequence 1: NP_001285196.1
• Gene: mew / 32275
• FlyBaseID: FBgn0004456
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: NP_795896.4
• Gene: Itga11 / 319480
• MGIID: 2442114
• Length: 1188
• Species: Mus musculus
• Alignment Length: 1341
• Identity: 279/1341 - (20%)
• Similarity: 472/1341 - (35%)
• Gaps: 435/1341 - (32%)

  Fly    34 FNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNRQPNTTHSGALWRCPM 98
            ||::.|.|.|..|...:.|||:|..|.|      :....::||||::.|....|   |.:::||:
Mouse    23 FNMDTRNPRVIAGPSAAFFGYTVQQHDI------SGKKWLVVGAPMETNGHQKT---GDVYKCPV 78

  Fly    99 TQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQANGSGGKVIVCAHRYMYI 163
            ||  .:|.::      |.....||  ...|.|::..:|:::.:||     .....:.|:..:.:.
Mouse    79 TQ--GNCTKL------NLGRVTLS--NVSERKDNMRLGLSLATNP-----KDNSFLACSPLWSHE 128

  Fly   164 VRENRYGQGLCYLLTNDLQF--------------------------------------------- 183
            ...:.|..|:|..:.::.:|
Mouse   129 CGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVEVQHFLINILKKFY 193

  Fly   184 ---------------EEVHE--------------------------------------------- 188
                           :.|||
Mouse   194 IGPGQIQVGIVQYGEDAVHEFHLNDYRSVKDVVEAASHIEQRGGTETRTAFGIEFARSEAFQKGG 258

  Fly   189 -------------------PCKGRPVQRQHED----YGLCQAG---------------------- 208
                               |...:.:::..:|    |.:...|
Mouse   259 RKGAKKVMIVITDGESHDSPDLEKVIRQSEKDNVTRYAVAVLGYYNRRGINPETFLNEIKYIASD 323

  Fly   209 ----------TSAALLD------------------------------------DDTMVLGSPGPY 227
                      ..|||.|                                    :|.::||:.|.|
Mouse   324 PDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVEDGILLGAVGAY 388

  Fly   228 TWRGSIWVTQVGGEYLQRDKTTYYSDHSDLNSPVDKYSYLGMSVTG------GRFFGHMSYAAGA 286
            .|.|::......|:.:...::.......:|.:..   :|||.:||.      ||.     |.|||
Mouse   389 DWNGAVLKETSAGKVIPHRESYLKEFPEELKNHA---AYLGYTVTSVVSSRQGRV-----YVAGA 445

  Fly   287 PRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELATADINGDHRPD-LIVAAPLYFTK-T 349
            ||....|:|::|....:..:.:|..|.|||.||.||.|:.:.|:|.|...| |:|.||:||:: .
Mouse   446 PRFNHTGKVILFSMHNNRSLTIHQALRGEQIGSYFGSEITSVDVNDDRVTDVLLVGAPMYFSEGR 510

  Fly   350 EGGAVYVYQNIQDTLPMKYTLKLTGPLE-SRFGLALANIGDLNKDNCEDLAVGAPYEGN--GVVY 411
            |.|.||||...|:......|||.:...: :|||..:|::.|||:|:..|:.||||.|.:  |.:|
Mouse   511 ERGKVYVYNLRQNRFVYNGTLKDSHSYQNARFGSCIASVQDLNQDSYNDVVVGAPLEDSHRGAIY 575

  Fly   412 IYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVI 476
            |:.|....:..||.|:|.||||.   |.   ::.||.||.|..||:::...|:.:||..:  ||:
Mouse   576 IFHGFQTNILKKPMQRITASELA---PG---LQHFGCSIHGQLDLNEDGLVDLAVGALGN--AVV 632

  Fly   477 LLARPIISIQTSV----QRKELHNMDPNTPGCLDDPASNLTCFTFRAC---CSIEPYDEKNKELR 534
            |.|||::.|..|:    .:..:.:.|....|      .:.||.....|   ..:.|:.: ...:.
Mouse   633 LWARPVVQINASLHFEPSKINIFHKDCKRNG------RDATCLAAFLCFIPIFLAPHFQ-TATVG 690

  Fly   535 LAYSVEAETFDHLKKFSRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANTRDIQTPVR 599
            :.|:.   |.|..:...|....:..::.||   |.|.: ::|:..||.:..:: .:|.|...||.
Mouse   691 IRYNA---TMDERRYMPRAHLDEGGDQFTN---RAVLL-SSGQEHCQRINFHV-LDTADYVKPVA 747

  Fly   600 FRLKYSLVEPPLADSALVRLNPILDQ---TQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITES 661
            |.::|||.:|   |:     .|:||.   |...|..  .|...|.:|:.|..:|::....::..:
Mouse   748 FSVEYSLEDP---DN-----GPMLDNGWPTTLRVSV--PFWNGCNEDEHCVPDLVLDARSDLPTA 802

  Fly   662 -------------SGNEYTLILDET---------ELEVRINVSNLADSAYEAQLFIAHQAGVSYV 704
                         ..:.|||..|.|         .:.|...:.|..::||.|.|.|:....:.:.
Mouse   803 MEYCQRVLGRPAQDCSSYTLSFDTTVFIIESTRRRVAVEATLENRGENAYSAVLNISQSENLQFA 867

  Fly   705 A----TKKPTNATCNSYNTTL--VACSLGNPMLRDTTTFVTIRFQPKGLEPSEKIMLFHIFANTT 763
            :    .....:..|.:....|  ..|::..|..| ....|..|..   .|.|:.:.|.|:..:..
Mouse   868 SLIQKDDSDNSIECVNEERRLHKKVCNVSYPFFR-AKAKVAFRLD---FEFSKSVFLHHLQIHLG 928

  Fly   764 SKLVGPERPERDLRVN---VVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGPMGMD 825
            :   |.:..|:|...:   .:.|..|.:..     ...::.||..:.....|.:.:|.:     |
Mouse   929 A---GSDSHEQDSTADDNTALLRFHLKYEA-----DVLFTRSSSLSHFEVKANSSLESY-----D 980

  Fly   826 DVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVA 890
            .:|...:.:|.:.|.|......|.|.|       :.|.:.|....||.|....|   .||.
Mouse   981 GIGPPFNCVFKVQNLGFFPIHGVMMKI-------TVPIATRGGNRLLMLRDFFT---DQGN---- 1031

  Fly   891 KEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNR 955
                ...|:...|.|   |.|.|.:             :.|.|:.:..:|:|
Mouse  1032 ----TSCNIWGNSTE---YRSTPTE-------------EDLSHAPQRNHSNS------------- 1063

  Fly   956 NRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNMPALSEAQVV 1020
                                            |:|.:.||             |.:....|....
Mouse  1064 --------------------------------DVVSIICN-------------LRLAPSQETSFY 1083

  Fly  1021 VKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDHN---NIEVETRAYPELRNQQRDTS 1082
            :...||.::|.:...|..::.:.:....|....:.....|.:   ..|:         ::|.|..
Mouse  1084 LVGNLWLTSLKALKYRSLKITVNAALQRQFHSPFIFREEDPSRQVTFEI---------SKQEDWQ 1139

  Fly  1083 IPWLIIILGIVGGLLLLALVTYVLWKVGFFKRI-RPTDPTL 1122
            :|..||:...:||||||||:...|||:||||.. |..:|.|
Mouse  1140 VPIWIIVGSTLGGLLLLALLVLALWKLGFFKSAKRKREPGL 1180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	18/62 (29%)
		Int_alpha	317..368	CDD:214549	22/52 (42%)
		Int_alpha	378..428	CDD:214549	21/51 (41%)
		Int_alpha	446..491	CDD:214549	18/48 (38%)
		Integrin_alpha2	479..1006	CDD:285619	104/567 (18%)
Itga11	NP_795896.4	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	24..85		23/71 (32%)
		Int_alpha	37..86	CDD:214549	18/59 (31%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	91..151		12/66 (18%)
		vWA_integrins_alpha_subunit	163..341	CDD:238746	10/177 (6%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	355..406		8/50 (16%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	411..461		17/57 (30%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	462..527		27/64 (42%)
		Int_alpha	476..523	CDD:214549	21/46 (46%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	528..586		21/57 (37%)
		Int_alpha	538..592	CDD:214549	21/53 (40%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	590..650		25/67 (37%)
		Integrin_alpha2	635..1034	CDD:285619	90/458 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810