DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itga4

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001101207.1	Gene:	Itga4 / 311144	RGDID:	1593249	Length:	1036	Species:	Rattus norvegicus

Alignment Length:	1141	Identity:	298/1141 - (26%)
Similarity:	490/1141 - (42%)	Gaps:	215/1141 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VLTCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAP-LDQNRQPNTTHSG 91
            |.|.:::||:....::..|...:.|||||..|:.|      ....::|||| .......:..:.|
  Rat    32 VPTGHSYNLDPESALLYQGPSGTLFGYSVVLHSHG------TKRWLIVGAPTASWLANASVVNPG 90

  Fly    92 ALWRCPMTQRFDD-CEQVITDGRRNFDSEILSPPGND------EIKEDQWMGVTVRSNPLQANGS 149
            |::||.:.:..:. |||:          ::.||.|..      |.:::||:|||:...|    |.
  Rat    91 AIYRCRIGKNPNQICEQL----------QLGSPSGEPCGKTCLEERDNQWLGVTISRQP----GE 141

  Fly   150 GGKVIVCAHRY---MYIVRENRYGQGLCYLLTNDLQFE--EVHEPCKGRPVQRQHEDYGLCQAGT 209
            .|.::.|.||:   .|:...|:...|:||.:.:||:.|  :...||....|::..|::..||||.
  Rat   142 NGSIVTCGHRWKNIFYMKNNNKLPTGVCYGMPSDLRTELSKRMAPCYQDFVRKFGENFASCQAGI 206

  Fly   210 SAALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSDLNSPVDKYSYLGMSVTGG 274
            | :....|.:|:|:||...|.||::|..:        .|..|....|..:.|...||||.||..|
  Rat   207 S-SFYTQDLIVMGAPGSSYWTGSVFVYNI--------TTNKYKAFVDRQNQVKFGSYLGYSVGAG 262

  Fly   275 RFFG-HMS-YAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELATADINGDHRPD 337
            .|.. |.: ...|||:.|..|:..|| ...::.:.:...:.|::.||.||..:...|:|.|...|
  Rat   263 HFRNPHTTEVVGGAPQHEQIGKAYIF-SIDESELTIVYEMKGKKLGSYFGASVCAVDLNADGFSD 326

  Fly   338 LIVAAPLYFTKTEGGAVYVYQNI---QDTLPMKYTLKLTGPLESRFGLALANIGDLNKDNCEDLA 399
            |:|.||:..|..|.|.|:||.|.   ...:.|:..|..:....:|||.::||:||::.|..||:|
  Rat   327 LLVGAPMQSTIREEGRVFVYINSGMGAVMVEMERVLVGSDKYAARFGESMANLGDIDNDGFEDIA 391

  Fly   400 VGAPYEGN--GVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYP 462
            :|||.|.:  |.||||.|...|::|..:|:|:..::      .|.:|.||.||||..|.|:|.|.
  Rat   392 IGAPQEDDLRGAVYIYNGRVDGISSTYSQRIEGRQI------SQSLRMFGQSISGQIDADNNGYV 450

  Fly   463 DVVIGAFNSSAAVILLARPIISIQTSVQRKELHN---MDPNTPGCLDDPASNLTCFTFRACCSIE 524
            ||.:|||.|.:||:|..||::.::.|:...|..|   .|....|.|.      .|...:.|
  Rat   451 DVAVGAFQSDSAVLLRTRPVVIVEASLSHPESVNRTKFDCTENGLLS------VCVDLKLC---- 505

  Fly   525 PYDEKNKE----LRLAYSVEAETFDHLKKFSRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTG 585
             :..|.||    :.|.|:|..:.....:..||.:||  .|..:::::|.:||.::|. :|:....
  Rat   506 -FSYKGKEVPGYIVLFYNVSLDVHRKAESPSRFYFF--SNGTSDMITRSIRVSSSGE-KCRTHQA 566

  Fly   586 YIKANTRDIQTPVRFRLKYSLVE-----------PPLADSALVRLNPILDQTQAHVDFEGT--FQ 637
            :::.:.|||.||::....|.|..           ||        |.|||.|.:.......|  |.
  Rat   567 FMRKDVRDILTPIQVEATYHLGHHVITKRNTEEFPP--------LQPILQQKKEKDIIRKTINFA 623

  Fly   638 KDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRINVS--NLADSAYEAQLFIAHQAG 700
            :.|..:: |.::|.:..:....:...|:..|.:...: .:.:|||  |..|.|||..|.:....|
  Rat   624 RFCAYEN-CSADLQVSAKVGFLKPYENKTYLAVGSMK-TIMLNVSLFNAGDDAYETTLNVQLPTG 686

  Fly   701 VSYV----ATKKPTNA-TCNSYNTTLVACSLGNPMLRDTTTFVTIRF--QPKGLEPSEKIMLFHI 758
            :.::    ..:|..|. ...|.....:|||||. :..|..:.:.|.|  ....|..:.:.:..::
  Rat   687 LYFIKILDLEEKQINCDVTESSGVVKLACSLGY-IYVDRLSRIDISFLLDVSSLSRAHEDLSINV 750

  Fly   759 FANTTSKLVGPERPERDLRVNVV----RRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEGH 819
            .|:..::  |.....:|.||.:|    ....|...|:..| .||..|||..|......|
  Rat   751 HASCENE--GKLDQVKDNRVTLVIPLRYEVMLAVHGFVTP-TSFVYGSSEENEPEMCMA------ 806

  Fly   820 GPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQ 884
                     .:::..|.:.|.|.|.||.|.:.|..|.|..  |::.:       |..|..|:.:.
  Rat   807 ---------EKLNLTFHVINTGISMAPNVSVKIMVPNSFL--PRNDK-------LFNVLDVQATM 853

  Fly   885 GECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSD 949
            |:|                                  |..| :.:....:|:...:.:..|
  Rat   854 GQC----------------------------------QFEH-YGRECALAQQKGIAGTLTD---- 879

  Fly   950 DTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNMPAL 1014
                     ...||.:..:  ||:|                   |.|...:|:...|:...|.:.
  Rat   880 ---------LVKFLSKTDK--RLLY-------------------CMKADRHCLDFLCNFGKMESG 914

  Fly  1015 SEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYPE-LRNQQ 1078
            .||.|.:  :|.....|.|......::....||| .||.: .:|::.|..|.....|.| |.:|:
  Rat   915 KEASVHI--QLEGRPSVLEMDETSSLKFEIKATA-FPEPH-PKVIELNKDENIAHVYLEGLHHQR 975

  Fly  1079 RDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKR 1114
            .......:|:.:.::.||::|.|::.|:||.|||||
  Rat   976 PKRHFTIVIVTISLLLGLIVLLLISCVMWKAGFFKR 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	18/64 (28%)
		Int_alpha	317..368	CDD:214549	20/53 (38%)
		Int_alpha	378..428	CDD:214549	24/51 (47%)
		Int_alpha	446..491	CDD:214549	22/44 (50%)
		Integrin_alpha2	479..1006	CDD:285619	113/559 (20%)
Itga4	NP_001101207.1	Int_alpha	52..109	CDD:214549	18/72 (25%)
		Int_alpha	307..355	CDD:214549	19/47 (40%)
		Int_alpha	370..422	CDD:214549	24/51 (47%)
		Int_alpha	433..483	CDD:214549	23/49 (47%)
		Integrin_alpha2	467..906	CDD:285619	113/559 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810