DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itgav

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_038962373.1	Gene:	Itgav / 296456	RGDID:	1310613	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	1193	Identity:	311/1193 - (26%)
Similarity:	509/1193 - (42%)	Gaps:	242/1193 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GILIILQCVLTCY--NFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTN--CVLVGAPLD 80
            |:|::|..:|..:  :|||:...|....|...|:||::|....      |:.::  .:|||||..
  Rat    15 GLLLLLLGLLLPFAGSFNLDVESPAEYAGPEGSYFGFAVDFFV------PSTSSRMFLLVGAPKA 73

  Fly    81 QNRQPNTTHSGALWRCPMTQRFDDCEQVITDGRR----NFDSEILSPPGND--------EIKEDQ 133
            ...||.....|.:.:|       ||    :..||    .|||     .||.        |.|..|
  Rat    74 NTTQPGIIEGGQVLKC-------DC----SSSRRCQPIEFDS-----TGNRDYAKDDPLEFKSHQ 122

  Fly   134 WMGVTVRSNPLQANGSGGKVIVCAHRYMY--IVRENRYGQGLCYLLTNDLQFEEVHEPCKGRPVQ 196
            |.|.:|||..       .|::.||..|.:  .:::.|...|.|:|.......|  :.||:.:.:.
  Rat   123 WFGASVRSKQ-------DKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVE--YAPCRSKNID 178

  Fly   197 RQHEDYGLCQAGTSAALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSD----- 256
            .  :..|.||.|.|......|.::||.||.:.|:|.:...||.....:.|...|...:::
  Rat   179 A--DGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIISKYDPNVYSIKYNNQLATR 241

  Fly   257 LNSPVDKYSYLGMSVTGGRFFGH--MSYAAGAPR-SEGHGQVVIFDKSTDNPIPVHSILDGEQFG 318
            ....:...||||.||..|.|.|.  ..:.:|.|| :...|.|.|:|..  |...:|: ..|||..
  Rat   242 TAQAIFDDSYLGYSVAVGDFNGDGIEDFVSGVPRAARTLGMVYIYDGK--NMSSLHN-FTGEQMA 303

  Fly   319 SSFGYELATADINGDHRPDLIVAAPLYFTKTEGGAVYVYQNIQDTLPMK----YTLKLTG-PLES 378
            :.||:.:|..|||||...|:.:.|||:..:...|.:.....:..:|...    .|.||.| .:.:
  Rat   304 AYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFA 368

  Fly   379 RFGLALANIGDLNKDNCEDLAVGAPYEG---NGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNG 440
            |||.|:|.:|||::|...|:|:.|||.|   .|:|||:.|.|.||||.|:|.:|......::|
  Rat   369 RFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGLVYIFNGRSTGLNSVPSQILQGQWAAQSMP-- 431

  Fly   441 QPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQ-RKELHNMDPNTPGC 504
               .:||.|:.|.||:|.|.|||:|:|||....||:..|||::::...:: ...:.|.| |....
  Rat   432 ---PSFGYSMKGATDVDRNGYPDLVVGAFGVDRAVLYRARPVVTVNAGLEVYPSILNQD-NKICP 492

  Fly   505 LDDPASNLTCFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKK---FSRVFFFDRENKRTNVL 566
            |...|..::||..|.|...:  .:.....:|.:.||. ..|.||:   ..|..|.   :.|:...
  Rat   493 LPGTALKVSCFNVRFCLKAD--GKGTLPRKLNFQVEL-LLDKLKQKGAIRRALFL---HNRSPGH 551

  Fly   567 SRVVRVHTNGRTECQAVTGYIK--ANTRDIQTPVRFRLKYSLVEPPLADSALVRLNPILDQ-TQA 628
            |:.:.|...|:|:|:.:..|::  :..||..||:...::|.|.:...||:  ..|.|||:| |.|
  Rat   552 SKDMTVFRGGQTQCEELVAYLRDESEFRDKLTPITIFMEYRLDQRTAADA--TGLQPILNQFTPA 614

  Fly   629 HVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRINVSNLADSAYEAQL 693
            :|..:.....|||:|::|:..|.:.|:      |..:...|.|:..|.:.:...|..:.||||:|
  Rat   615 NVSRQAHILLDCGEDNVCKPKLEVSVD------SDQKKIYIGDDNPLTLTVKAQNQGEGAYEAEL 673

  Fly   694 FIAHQAGVSYVATKKPTNA----TC---NSYNTTLVACSLGNPMLRDTTTFVTIRF---QPKGLE 748
            .::......::...:...|    :|   ....|..|.|.|||||...|.....:||   |...::
  Rat   674 IVSIPPQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMD 738

  Fly   749 PSE----KIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVAN-SV 808
            .|.    ||...:.|.|.:        |....:|::...|.:..||.:.|:..|.   .:.| ..
  Rat   739 TSVKFDLKIQSSNSFDNVS--------PVVSYKVDLAVLAAVEIRGVSSPDHIFL---PIPNWEY 792

  Fly   809 ANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLY 873
            ..|..|:         :|||..|.|::.:.|.|||:..|..:.:.|||...::.        |||
  Rat   793 KETPETE---------EDVGPVVQHIYELRNNGPSSFSKAILNLQWPYKYNNNT--------LLY 840

  Fly   874 LEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSY 938
            :              :..:...|:|..:.:..||..:..|
  Rat   841 I--------------LHYDIDGPMNCTADTEINPLRIKTP------------------------- 866

  Fly   939 YSSSHRDDHSDDT---QSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATN 1000
                    ..:||   |..||.:       :|:.:..:           .:.|:..|.|  |...
  Rat   867 --------EKNDTAAEQGGRNHL-------ITKRDLSL-----------SEGDVHTLGC--GTAQ 903

  Fly  1001 CVRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIE 1065
            |::|.|.:..:.....|.:.||:.||..|.:::..:.....:.|:|      |:.:....:.|:.
  Rat   904 CLQITCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSA------SFNIIEFPYKNLP 962

  Fly  1066 VETRAYPELRN------------QQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPT 1118
            :|     :|.|            |.....:|..:|||.::.||||||::.:|::::|||||:||
  Rat   963 IE-----DLFNSTLVTTNITWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRP- 1021

  Fly  1119 DPTLSGNLEKMNEEKPFLAPSKN 1141
                    .:..:|:..|.|.:|
  Rat  1022 --------PQEEQEREQLQPHEN 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	16/64 (25%)
		Int_alpha	317..368	CDD:214549	14/54 (26%)
		Int_alpha	378..428	CDD:214549	27/52 (52%)
		Int_alpha	446..491	CDD:214549	20/45 (44%)
		Integrin_alpha2	479..1006	CDD:285619	122/551 (22%)
Itgav	XP_038962373.1	Int_alpha	46..103	CDD:214549	18/73 (25%)
		WD40 repeat	126..183	CDD:293791	14/67 (21%)
		WD40 repeat	188..248	CDD:293791	13/59 (22%)
		VCBS	221..271	CDD:404411	11/49 (22%)
		Int_alpha	248..>288	CDD:214549	15/39 (38%)
		WD40 repeat	254..298	CDD:293791	14/46 (30%)
		Int_alpha	302..355	CDD:214549	14/52 (27%)
		WD40 repeat	307..362	CDD:293791	15/54 (28%)
		Int_alpha	367..421	CDD:214549	27/53 (51%)
		WD40 repeat	371..422	CDD:293791	25/50 (50%)
		Int_alpha	434..476	CDD:214549	20/41 (49%)
		Integrin_alpha2	467..909	CDD:400650	122/551 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335696
Domainoid	1	1.000	54	1.000	Domainoid score	I10920
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850