DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itga1

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_112256.1	Gene:	Itga1 / 25118	RGDID:	2923	Length:	1180	Species:	Rattus norvegicus

Alignment Length:	1384	Identity:	313/1384 - (22%)
Similarity:	493/1384 - (35%)	Gaps:	478/1384 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RQNLGILIILQCV--LT-----CYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCV 73
            |:...:.:.:.|:  ||     |.:||::.:..:...|.....|||:|..:...|.      ..|
  Rat     4 RRPASLEVTVACIWLLTVILGFCVSFNVDVKNSMSFSGPVEDMFGYTVQQYENEEG------KWV 62

  Fly    74 LVGAPLDQNRQPNTTHSGALWRCPM-TQRFDDCEQVITDGRRNFDSEI-LSPPGNDEIKEDQWMG 136
            |:|:||  ..||. ..:|.:::||: .:|...|.::        |..: .|.|...||||:...|
  Rat    63 LIGSPL--VGQPK-ARTGDVYKCPVGRERAMPCVKL--------DLPVNTSIPNVTEIKENMTFG 116

  Fly   137 VTVRSNPLQANGSGGKVIVCAHRYMYIVRENRYGQGLC--------------------------- 174
            .|:.:||      .|..:.|...|.|......|..|:|
  Rat   117 STLVTNP------NGGFLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSFAPVQECSTQLDIVI 175

  Fly   175 --------------YLLTNDL-------------------------------------------- 181
                          ....|||
  Rat   176 VLDGSNSIYPWESVIAFLNDLLKRMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAANKI 240

  Fly   182 ------------------------------------------------QFEEVHEPCKGRPVQR- 197
                                                            :.::|.:.|:...:||
  Rat   241 GRQGGLQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNYRLKQVIQDCEDENIQRF 305

  Fly   198 -----QHEDYG------------------------------------------------------ 203
                 .|.:.|
  Rat   306 SIAILGHYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKALGERIFALEATADQSA 370

  Fly   204 ------LCQAGTSAALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSDLNSPVD 262
                  :.|.|.||. ...|.::||:.|.|.|.|:: |.|...:.:....||:.::.:.:|.|:
  Rat   371 ASFEMEMSQTGFSAH-YSQDWVMLGAVGAYDWNGTV-VMQKANQMVIPHNTTFQTEPAKMNEPL- 432

  Fly   263 KYSYLGMSVTGGRFFGHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELAT 327
             .||||.:|......|.:.|.||.||....|||||: |..|..|.:...|.|||.||.||..|.|
  Rat   433 -ASYLGYTVNSATIPGDVLYIAGQPRYNHTGQVVIY-KMEDGNINILQTLGGEQIGSYFGSVLTT 495

  Fly   328 ADINGDHRPD-LIVAAPLYF--TKTEGGAVYVYQNIQDTL-------PMKYT----LK------- 371
            .||:.|...| |:|.||:|.  .|.|.|.||||...|...       |::.|    ||
  Rat   496 IDIDKDSYTDLLLVGAPMYMGTEKEEQGKVYVYAVNQTRFEYQMSLEPIRQTCCSSLKDNSCTKE 560

  Fly   372 -LTGPLESRFGLALANIGDLNKDNCEDLAVGAPYEGN--GVVYIYLGSSQGLNSKPAQKIQASEL 433
             ...|..:|||.|:|.:.|||.|...|:.:|||.|.:  |.||||.||.:.:....||:|.:
  Rat   561 NKNEPCGARFGTAIAAVKDLNVDGFNDVVIGAPLEDDHAGAVYIYHGSGKTIREAYAQRIPS--- 622

  Fly   434 GGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMD 498
            ||   :|:.::.||.||.|..||:.:...||.||....:|  :..||.:..::.::      |.:
  Rat   623 GG---DGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAA--LFWARDVAVVKVTM------NFE 676

  Fly   499 PN-----TPGCLDDPASNLTCFTFRACCSIEPYDEKNK--ELRLAYSVEAETFDHLKKFSRVFFF 556
            ||     ...|..: .....|.....|..::...:::.  |..|.|.|   |.|.|::.||.||.
  Rat   677 PNKVNIQKKNCRVE-GKETVCINATMCFHVKLKSKEDSIYEADLQYRV---TLDSLRQISRSFFS 737

  Fly   557 DRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEP---PLADSALVR 618
            ..:.::   :.|.:.|.   .:||...:.|: .:..|.|..||..|.::|.:|   |:.|.||.
  Rat   738 GTQERK---IQRNITVR---ESECIRHSFYM-LDKHDFQDSVRVTLDFNLTDPENGPVLDDALP- 794

  Fly   619 LNPILDQTQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETE---LEVRIN 680
                 :....|:    .|.||||:.:.|.|:|.:.|       |..|.:|::.:::   ..|.:.
  Rat   795 -----NSVHEHI----PFAKDCGNKERCISDLTLNV-------STTEKSLLIVKSQHDKFNVSLT 843

  Fly   681 VSNLADSAYEAQLFIAHQAGVSYVATKKPTNATCNSYNTTLVACSLGNPMLR--DTTTFVTIRFQ 743
            |.|..||||..:..:.|...:.:...::....:|.|...  :.|.:|.|.||  :|.||..| ||
  Rat   844 VKNKGDSAYNTRTVVQHSPNLIFSGIEEIQKDSCESNQN--ITCRVGYPFLRAGETVTFKII-FQ 905

  Fly   744 PKGLEPSEKIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQ-----SFYSGSS 803
            ......||..:: |:.|.:.|     |.|...|..|.|        ..:||.:     .|||.:|
  Rat   906 FNTSHLSENAII-HLSATSDS-----EEPLESLNDNEV--------NISIPVKYEVGLQFYSSAS 956

  Fly   804 VANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPV 868
            ..:  .:.||.:.........:|:|::::..:||...|....|::|:.|.:| :|.:|   |.||
  Rat   957 EHH--ISVAANETIPEFINSTEDIGNEINVFYTIRKRGHFPMPELQLSISFP-NLTAD---GYPV 1015

  Fly   869 QYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIH 933
            .|                         |:.
  Rat  1016 LY-------------------------PIG----------------------------------- 1020

  Fly   934 SQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGA 998
                 :|||                     :.|....|.:.||...|  :|||..|.:.:..|..
  Rat  1021 -----WSSS---------------------DNVNCRPRSLEDPFGIN--SGKKMTISKSEVLKRG 1057

  Fly   999 T--NC------VRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYG 1055
            |  :|      ..|.|.:|  |: ..:||.|...||..|.:..:        ||:....:   .|
  Rat  1058 TIQDCSSTCGVATITCSLL--PS-DLSQVNVSLLLWKPTFIRAH--------FSSLNLTL---RG 1108

  Fly  1056 VEVMDHNNIEVETRAYPELRNQQRDTSI-----------PWLIIILGIVGGLLLLALVTYVLWKV 1109
            ....:::::.:.:      .|::|:.:|           |..:|:|....|||||.|:...|||:
  Rat  1109 ELKSENSSLTLSS------SNRKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILALWKI 1167

  Fly  1110 GFFKRIRPTDPTLSGNLEK 1128
            |||||      .|...:||
  Rat  1168 GFFKR------PLKKKMEK 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	17/63 (27%)
		Int_alpha	317..368	CDD:214549	24/60 (40%)
		Int_alpha	378..428	CDD:214549	23/51 (45%)
		Int_alpha	446..491	CDD:214549	14/44 (32%)
		Integrin_alpha2	479..1006	CDD:285619	119/554 (21%)
Itga1	NP_112256.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	30..91		18/69 (26%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	101..160		17/64 (27%)
		vWA_integrins_alpha_subunit	171..351	CDD:238746	9/179 (5%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	365..417		13/53 (25%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	422..474		20/54 (37%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	475..537		27/61 (44%)
		Int_alpha	485..>528	CDD:214549	20/42 (48%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	556..614		22/57 (39%)
		Int_alpha	567..620	CDD:214549	23/52 (44%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	618..678		20/73 (27%)
		Integrin_alpha2	663..1073	CDD:285619	119/554 (21%)
		GFFKR motif	1168..1172		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335759
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840