DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itgam

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_006230276.1	Gene:	Itgam / 25021	RGDID:	2926	Length:	1152	Species:	Rattus norvegicus

Alignment Length:	1225	Identity:	272/1225 - (22%)
Similarity:	451/1225 - (36%)	Gaps:	396/1225 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNC---------------------- 72
            |.:.||..:|.|     .|.||      ...|.:.||..||..
  Rat   198 THFTFNDFKRNP-----DPKSH------VRPIRQLNGRTKTASGIRKVVRELFQKINGARDNAAK 251

  Fly    73 VLV--------GAPLD-QNRQPNTTHSGALWRCPMTQRFDDCEQVITDG--------RRNFDSEI 120
            :||        |.||: ::..|....:|.:            ..||..|        ||..|:..
  Rat   252 ILVVITDGEKFGDPLNYEDVIPEAEEAGII------------RYVIGVGNAFHKPQSRRELDTIA 304

  Fly   121 LSPPGNDEIKEDQWMGVTVRSNPLQANGSGGKVIVCAHRYMYIVRENRYGQGLCYLLTNDLQFEE 185
            ..|.|:...:.|.:..:....|.||..             ::.:...:.|....:
  Rat   305 SKPAGDHVFQVDNFEALNTIRNQLQEK-------------IFAIEGTQTGSTSSF---------- 346

  Fly   186 VHEPCKGRPVQRQHEDYGLCQAGTSAALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTY 250
                        :||   :.|.|.|||:..:..: |||.|.:.|.|..::      |..:||.|:
  Rat   347 ------------EHE---MSQEGFSAAITSNGPL-LGSVGSFDWAGGAFL------YPSKDKATF 389

  Fly   251 YSD---HSDLNSPVDKYSYLGMS---VTGGRFFGHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVH 309
            .:.   .||:|.     :|||.:   ::..|.   .|...||||.:..|.||:|.::.....| |
  Rat   390 INTTRIDSDMND-----AYLGYASAVISRNRV---QSLVLGAPRYQHIGLVVMFKQNFGAWEP-H 445

  Fly   310 SILDGEQFGSSFGYELATADINGDHRPDLI-VAAPLYFTKTEGGAVYVYQNIQDTLPMKYTLKLT 373
            :.:.|.|.||.||..|.:.|::.|...:|| :.||.::.||.||.|.|       .|:....:..
  Rat   446 TDIKGSQIGSYFGASLCSVDMDADGNTNLILIGAPHHYEKTRGGQVSV-------CPLPRGQRAR 503

  Fly   374 GPLES-----------RFGLALANIGDLNKDNCEDLAVGAP--YEGNGVVYIYLGSSQGLNSKP- 424
            ...|:           |||.||..:||:|.|...|:|:|||  .|..|.|||:.|:|....|.|
  Rat   504 WQCEAILHGDQGHPWGRFGAALTVLGDVNGDKLTDVAIGAPGEQENQGAVYIFHGASVASISTPH 568

  Fly   425 AQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSV 489
            :|:|    .|.....|  ::.||.|:||..||..:...|:.:||  ....:::.|:|::.::.::
  Rat   569 SQRI----AGARFSPG--LQYFGQSLSGGKDLTMDGLMDLAVGA--QGRLLLIRAQPVLRLEATM 625

  Fly   490 QRKELHNMDPNTPGCLDDPASNLTCFTFRACCSIEPYDEKNKELRL---------AYSVEAETFD 545
            :... .|:..:...|.::...|......|.|..:    .||.:.||         .|.:   ..|
  Rat   626 EFSP-KNLARSVFACQEEVVKNKDAGEVRVCLHV----RKNTKDRLREGDIQSTVTYDL---ALD 682

  Fly   546 HLKKFSRVFFFDRENKRTNVLSRVVRVHTNGRTE-CQAVTGYIKANTRDIQTPVRFRLKYSLVEP 609
            ..:...|.||.:.:|   .:|.| :||.  |.|: |:.:...:.....:..:|:..||.|:||..
  Rat   683 PGRSVVRAFFDETKN---GILRR-IRVF--GLTQKCETLKLILPDCVDNSVSPIILRLNYTLVGE 741

  Fly   610 PLADSALVRLNPILDQTQAHVDFEG--TFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLIL-D 671
            ||..|.  .|.|:| ..:|...|..  .|:|:||:|.:|:.:|      :||.||....||:: |
  Rat   742 PLRSSR--DLRPVL-AMEAQRIFTAMFPFEKNCGNDTICQDDL------SITVSSIRVNTLVVGD 797

  Fly   672 ETELEVRINVSNLADSAYEAQLFIAHQAGVSYVATKKPTNATCNSYNT---TLVA---CSLGNPM 730
            ..:.:|.:.:.|..:.:|..::...:.:|:||    :..:|:.|.::.   .::|   .|.|..:
  Rat   798 SRDFDVSVTLRNDGEDSYGTKVTCYYPSGLSY----RKVSASQNQFSKKPWRVIAEPSSSEGQGV 858

  Fly   731 LRDTTTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPE 795
            |:.|.                                                       |.|..
  Rat   859 LKSTI-------------------------------------------------------WDINH 868

  Fly   796 QSFYSGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNE-GPSTAPKVQMVIHWPYSLY 859
            ..|.:.|.|..:|.....:|.         .:|:::.....:.:| ..|...|
  Rat   869 PIFPANSEVTFNVTFDVDSDA---------SLGNKLLLKVVVTSENNVSRTDK------------ 912

  Fly   860 SDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSR 924
            ::.|...||:|.:|:      .|:.||..:  :|:|               ...::|.....|.:
  Rat   913 TESQLELPVKYAIYM------VVTSGESSI--KYLN---------------FTASEMTSKVIQHQ 954

  Fly   925 HSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSF-----------LERVTRLERLMYDP-- 976
            :.||                           |..:|||           :.:||     ::||
  Rat   955 YQFN---------------------------NLGQRSFPVSVVFWIPVQINKVT-----IWDPPQ 987

  Fly   977 -------------ESSNAANGKKQDIVE----LDCNKGATNCVRIECDILNMPALSEAQVVVKAR 1024
                         |..:.::.|.||.:|    |:|:...  |.||:|||   |:.:..: :....
  Rat   988 VTFSQNLSSVCRTEQKSPSHSKFQDELERTPVLNCSVAV--CKRIQCDI---PSFNSKE-IFNVT 1046

  Fly  1025 LWNSTLVSEYPRVERVRIFSTATAQI----------PESYGVEVMDHNNIEVETRAYPELRNQQR 1079
            |..:.|...|.......:...:||:|          |   |.|.......|.:...| ::.|
  Rat  1047 LQGNLLFDWYIETSHDHLLLVSTAEILFNDSAFALLP---GQETFVKAQTETKVEPY-KVHN--- 1104

  Fly  1080 DTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGNLEKMNEEKP 1134
                |..:|:...||||:||||:|..|:|:|||||         ...:.|||..|
  Rat  1105 ----PVPLIVGSSVGGLVLLALITAGLYKLGFFKR---------QYKDMMNEAAP 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	17/93 (18%)
		Int_alpha	317..368	CDD:214549	18/51 (35%)
		Int_alpha	378..428	CDD:214549	24/63 (38%)
		Int_alpha	446..491	CDD:214549	12/44 (27%)
		Integrin_alpha2	479..1006	CDD:285619	108/576 (19%)
Itgam	XP_006230276.1	vWA_integrins_alpha_subunit	149..324	CDD:238746	29/148 (20%)
		Int_alpha	453..510	CDD:214549	19/63 (30%)
		Int_alpha	517..570	CDD:214549	23/52 (44%)
		Int_alpha	582..>606	CDD:214549	8/23 (35%)
		Integrin_alpha2	615..1032	CDD:285619	108/576 (19%)
		Integrin_alpha	1129..1141	CDD:278771	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900