DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mew and ITGA11

DIOPT Version :9

Sequence 1:NP_001285196.1 Gene:mew / 32275 FlyBaseID:FBgn0004456 Length:1243 Species:Drosophila melanogaster
Sequence 2:NP_001004439.1 Gene:ITGA11 / 22801 HGNCID:6136 Length:1188 Species:Homo sapiens


Alignment Length:1359 Identity:281/1359 - (20%)
Similarity:467/1359 - (34%) Gaps:469/1359 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 FNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNRQPNTTHSGALWRCPM 98
            ||::.|.|.|..|...:.|||:|..|.|    ..||  .::|||||:.|....|   |.:::||:
Human    23 FNMDTRKPRVIPGSRTAFFGYTVQQHDI----SGNK--WLVVGAPLETNGYQKT---GDVYKCPV 78

  Fly    99 TQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQANGSGGKVIVCAHRYMYI 163
            ..  .:|.::      |.....||  ...|.|::..:|:::.:||     .....:.|:..:.:.
Human    79 IH--GNCTKL------NLGRVTLS--NVSERKDNMRLGLSLATNP-----KDNSFLACSPLWSHE 128

  Fly   164 VRENRYGQGLCYLLTNDLQFEE------------------------------------------- 185
            ...:.|..|:|..:.::.:|.:                                           
Human   129 CGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVEVQHFLINILKKFY 193

  Fly   186 -----------------VHE--------------------------------------------- 188
                             |||                                             
Human   194 IGPGQIQVGVVQYGEDVVHEFHLNDYRSVKDVVEAASHIEQRGGTETRTAFGIEFARSEAFQKGG 258

  Fly   189 -------------------PCKGRPVQRQHED----YGLCQAG---------------------- 208
                               |...:.:|:...|    |.:...|                      
Human   259 RKGAKKVMIVITDGESHDSPDLEKVIQQSERDNVTRYAVAVLGYYNRRGINPETFLNEIKYIASD 323

  Fly   209 ----------TSAALLD------------------------------------DDTMVLGSPGPY 227
                      ..|||.|                                    :|.::||:.|.|
Human   324 PDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVEDGVLLGAVGAY 388

  Fly   228 TWRGSIWVTQVGGEYLQRDKTTYYSDHSDLNSPVDKYSYLGMSVTG------GRFFGHMSYAAGA 286
            .|.|::......|:.:...::.......:|.   :..:|||.:||.      ||.     |.|||
Human   389 DWNGAVLKETSAGKVIPLRESYLKEFPEELK---NHGAYLGYTVTSVVSSRQGRV-----YVAGA 445

  Fly   287 PRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELATADINGDHRPD-LIVAAPLYFTK-T 349
            ||....|:|::|....:..:.:|..:.|:|.||.||.|:.:.||:||...| |:|.||:||.: .
Human   446 PRFNHTGKVILFTMHNNRSLTIHQAMRGQQIGSYFGSEITSVDIDGDGVTDVLLVGAPMYFNEGR 510

  Fly   350 EGGAVYVYQNIQDTLPMKYTLKLTGPLE-SRFGLALANIGDLNKDNCEDLAVGAPYEGN--GVVY 411
            |.|.||||:..|:......|||.:...: :|||.::|::.|||:|:..|:.||||.|.|  |.:|
Human   511 ERGKVYVYELRQNLFVYNGTLKDSHSYQNARFGSSIASVRDLNQDSYNDVVVGAPLEDNHAGAIY 575

  Fly   412 IYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVI 476
            |:.|....:...|.|:|.||||      ...::.||.||.|..||:::...|:.:||..:  |||
Human   576 IFHGFRGSILKTPKQRITASEL------ATGLQYFGCSIHGQLDLNEDGLIDLAVGALGN--AVI 632

  Fly   477 LLARPIISIQTSV----QRKELHNMDPNTPG----CLDDPASNLTCFT-------FRACCSIEPY 526
            |.:||::.|..|:    .:..:.:.|....|    ||    :...|||       |:.......|
Human   633 LWSRPVVQINASLHFEPSKINIFHRDCKRSGRDATCL----AAFLCFTPIFLAPHFQTTTVGIRY 693

  Fly   527 DEKNKELRLAYSVEAETFDHLKKFSRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANT 591
            :....|.|  |:..|    ||.:..     ||...|..:||       :|:..|:.:..:: .:|
Human   694 NATMDERR--YTPRA----HLDEGG-----DRFTNRAVLLS-------SGQELCERINFHV-LDT 739

  Fly   592 RDIQTPVRFRLKYSLVEPPLADSALVRLNPILDQ---TQAHVDFEGTFQKDCGDDDLCESNLIIR 653
            .|...||.|.::|||.:|.        ..|:||.   |...|..  .|...|.:|:.|..:|::.
Human   740 ADYVKPVTFSVEYSLEDPD--------HGPMLDDGWPTTLRVSV--PFWNGCNEDEHCVPDLVLD 794

  Fly   654 VEPNITES-------------SGNEYTLILDET---------ELEVRINVSNLADSAYEAQLFIA 696
            ...::..:             ..:.|||..|.|         .:.|...:.|..::||...|.|:
Human   795 ARSDLPTAMEYCQRVLRKPAQDCSAYTLSFDTTVFIIESTRQRVAVEATLENRGENAYSTVLNIS 859

  Fly   697 HQAGVSYVA--TKKPTNATCNSYN----TTLVACSLGNPMLRDTTTFVTIRFQPKGLEPSEKIML 755
            ..|.:.:.:  .|:.::.:....|    .....|::..|..| ....|..|..   .|.|:.|.|
Human   860 QSANLQFASLIQKEDSDGSIECVNEERRLQKQVCNVSYPFFR-AKAKVAFRLD---FEFSKSIFL 920

  Fly   756 FHIFANTTSKLVGPERPERD---------LRVNVVRRAKLNF-RGWAIPEQSFYSGSSVANSVAN 810
            .|:.....:   |.:..|||         ||.::...|.:.| |..::........||:..    
Human   921 HHLEIELAA---GSDSNERDSTKEDNVAPLRFHLKYEADVLFTRSSSLSHYEVKPNSSLER---- 978

  Fly   811 TAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLE 875
                         .|.:|.....:|.|.|.|                |:  |..|..::..:   
Human   979 -------------YDGIGPPFSCIFRIQNLG----------------LF--PIHGMMMKITI--- 1009

  Fly   876 QVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYS 940
                                |:...||:|          .:::                      
Human  1010 --------------------PIATRSGNR----------LLKL---------------------- 1022

  Fly   941 SSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIE 1005
               ||..:|:..::.|....|...|.|.:|.   |...:...|....|:|.::||          
Human  1023 ---RDFLTDEANTSCNIWGNSTEYRPTPVEE---DLRRAPQLNHSNSDVVSINCN---------- 1071

  Fly  1006 CDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNN---IEVE 1067
               :.:....|....:...||..:|.:...:..::.:.:....|....:.....|.:.   .|: 
Human  1072 ---IRLVPNQEINFHLLGNLWLRSLKALKYKSMKIMVNAALQRQFHSPFIFREEDPSRQIVFEI- 1132

  Fly  1068 TRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIR-----PTDPT 1121
                    ::|.|..:|..||:...:||||||||:...|||:|||:..|     ..|||
Human  1133 --------SKQEDWQVPIWIIVGSTLGGLLLLALLVLALWKLGFFRSARRRREPGLDPT 1183

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mewNP_001285196.1 Int_alpha 48..111 CDD:214549 19/62 (31%)
Int_alpha 317..368 CDD:214549 23/52 (44%)
Int_alpha 378..428 CDD:214549 21/51 (41%)
Int_alpha 446..491 CDD:214549 18/48 (38%)
Integrin_alpha2 479..1006 CDD:285619 107/582 (18%)
ITGA11NP_001004439.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 24..85 24/71 (34%)
Int_alpha 39..>78 CDD:214549 17/47 (36%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 91..151 12/66 (18%)
vWA_integrins_alpha_subunit 163..341 CDD:238746 11/177 (6%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 355..406 8/50 (16%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 411..461 17/57 (30%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 462..527 26/64 (41%)
Int_alpha 476..>518 CDD:214549 20/41 (49%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 528..586 22/57 (39%)
Int_alpha 538..592 CDD:214549 21/53 (40%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 590..650 24/67 (36%)
Integrin_alpha2 635..1034 CDD:285619 96/531 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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