DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itga10

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001289400.1	Gene:	Itga10 / 213119	MGIID:	2153482	Length:	1166	Species:	Mus musculus

Alignment Length:	1361	Identity:	294/1361 - (21%)
Similarity:	465/1361 - (34%)	Gaps:	443/1361 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 QNLGI--LIILQCVLT--CYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGA 77
            ::|.|  |::...:||  |.:|||::..|.:..|.|.:.|||||..|..|      ....:||||
Mouse     2 ESLSIPHLLLPLALLTGLCSSFNLDEHHPRLFTGPPEAEFGYSVLQHVGG------GQRWMLVGA 60

  Fly    78 PLDQNRQPNTTHSGALWRC--------PMTQRFDDCEQVITDGRRNFDSEILSPPGN----DEIK 130
            |.|   .|:....|.::||        |.|:..      :.|.:....|:   |..|    ..:.
Mouse    61 PWD---GPSGDRRGDVYRCSIGGFHSAPCTKGH------LGDYQLGNSSQ---PAVNMHLGMSLL 113

  Fly   131 EDQWMGVTVRSNPLQANGSGGKVI---VCAH-------------------RYMYIV--------- 164
            |....|..:...||.:...|..|.   :||.                   .||.:|
Mouse   114 ETDADGGFMACAPLWSRACGSSVFSSGICARVDASFRPQGSLAPTAQRCPTYMDVVIVLDGSNSI 178

  Fly   165 --------------------------------------------------------------REN 167
                                                                          ||.
Mouse   179 YPWSEVQTFLRRLVGRLFIDPEQIQVGLVQYGENPVHEWSLGDFRTKEEVVRAARNLSRREGRET 243

  Fly   168 RYGQGLCYLLTNDLQFEEVHEPCKGRPVQ----------RQHEDYGL------CQAG-------- 208
            |..|.:....|     |...:...|||..          ..|:...|      |:||
Mouse   244 RTAQAIMVACT-----EGFSQSRGGRPEAARLLVVVTDGESHDGEELPAALKACEAGRVTRYGIA 303

  Fly   209 -----------------------------------TSAALLD----------------------- 215
                                               ..|||.|
Mouse   304 VLGHYLRRQRDPSSFLREIRAIASDPDERFFFNVTDEAALTDIVDALGDRIFGLEGSRGENESSF 368

  Fly   216 --------------DDTMVLGSPGPYTWRGSIWVTQVGGEY------LQRDKTTYYSDHSDLNSP 260
                          .|.::.|..|.|.|.||:...:.|...      |:.:......:|:
Mouse   369 GLEMSEIGFSIHRLQDGILFGMVGAYDWGGSVLWLEEGRRLFPPQAALEDEFPPALQNHA----- 428

  Fly   261 VDKYSYLGMSVT-----GGRFFGHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSS 320
                :|||.||:     |||    ..:.:||||....|:|:.|....|..:.|...|.|:|.||.
Mouse   429 ----AYLGYSVSSMLLPGGR----RLFLSGAPRFRHRGKVIAFQLKKDGVVRVAQSLQGDQIGSY 485

  Fly   321 FGYELATADINGDHRPD-LIVAAPLYF--TKTEGGAVYVYQ-NIQDTLPMKYTLKLTGPLESRFG 381
            ||.||...|.:.|...: |:||||::.  ...|.|.||||. ..|:.|.::.||:.....:||||
Mouse   486 FGSELCPLDTDKDGITNILLVAAPMFLGPQNKETGRVYVYMVGQQNLLMLQGTLQPDRSQDSRFG 550

  Fly   382 LALANIGDLNKDNCEDLAVGAPYEG--NGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIR 444
            .|:|.:.|||.|...|:|||||.|.  .|.:|:|.|:..|:...|.|:|.|      :...|.:|
Mouse   551 FAMAALPDLNHDGFTDVAVGAPLEDGHRGALYLYHGTQTGIRPHPTQRIAA------VSMPQALR 609

  Fly   445 TFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPNTPGCLDD-- 507
            .||.|:.|..|||.:...||.:||  ..|||:..::|||.:..:     |..|.|:......|
Mouse   610 YFGRSVDGRLDLDGDDLVDVAVGA--HGAAVLFSSQPIIHLIPT-----LDVMPPHISVVQKDCK 667

  Fly   508 -PASNLTCFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKKFSRVFFFDRENKRTNVLSRVVR 571
             ......|.|...|..:........:.|. |...:.:.|.....:|. .||...:|.:.....:.
Mouse   668 RRGQEAACLTAALCFQVVSQTPGRWDRRF-YIRFSASLDEWTAGARA-VFDGSGQRLSPRQLQLS 730

  Fly   572 VHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVE-----PPLADSALVRLNPILDQTQAHVD 631
            |   |...|:.: .:...:|.|...||...:.::|..     |.||:.:...:..::
Mouse   731 V---GNVTCEQL-HFHALDTSDYLRPVALTVTFALDNTTKPGPVLAEGSSTTIRKLI-------- 783

  Fly   632 FEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRINVSNLADSAYEAQLFIA 696
               .|.||||.|:.|.::|:::.:.:|..|..:.:.:.....::.|...:.|..::||...|.::
Mouse   784 ---PFSKDCGPDNECVTDLVLQADMDIRGSRKSPFVVQGGRQKVLVSATLENKKENAYNTSLSLS 845

  Fly   697 -----HQAGVSYVATKKPTNATCNSYNTTLVACSLGNPMLRDTTTFVTIRFQPKGLEPSEKIMLF 756
                 |.|.::..|..........|.:|.|  |::|:|:.:   |...:.|..: .|.|...:|.
Mouse   846 FSRNLHLASLTPQAKSVKVECAVPSPHTRL--CTVGHPVFQ---TGAKVSFLLE-FEFSCTFLLS 904

  Fly   757 HIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGP 821
            .:|...|:.                             ..|.....::.::.|.|:|.
Mouse   905 QVFVRLTAS-----------------------------SSSLEMNETLQDNTAQTSAY------- 933

  Fly   822 MGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGE 886
                 :..:.|.:|:    ..||..:.:  :| ||...  |....|       |...|:.|....
Mouse   934 -----IRYEPHLVFS----SESTLHRYE--VH-PYRTL--PMGPGP-------EFKTTLRVQNLG 977

  Fly   887 CHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDT 951
            |||....|               :||     :.|:.: |..|..|..||  ..|.:......:.|
Mouse   978 CHVVSGLV---------------ISA-----LLPAVA-HGGNYFLSLSQ--VISGNASCTVQNLT 1019

  Fly   952 QSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCN-----KGATNCVRIECDILNM 1011
            :.....|....|:..:||          |.:|.:.|.:   .|:     ||....||       :
Mouse  1020 EPPGFPVHPEELQHASRL----------NGSNSRCQVV---RCHLGLLAKGTEISVR-------L 1064

  Fly  1012 PALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVE---VMDHNNIEVETRAYPE 1073
            ..|...:...:|:..:.|:||.:                  ..|.|   |:..|.....:.::.|
Mouse  1065 LRLVHNEFFRRAKFKSVTVVSTF------------------KLGTEEGSVLLLNEASRSSESHLE 1111

  Fly  1074 LRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIR-PTDPTLSGNLEKMNEEK 1133
            : .|...|.|...|::..::||||||||:.:.|||:|||.|.: |.        |:.:|||
Mouse  1112 V-IQTHPTLISLWILVGSVLGGLLLLALLVFCLWKLGFFTRKKIPK--------EEESEEK 1163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	20/70 (29%)
		Int_alpha	317..368	CDD:214549	21/54 (39%)
		Int_alpha	378..428	CDD:214549	24/51 (47%)
		Int_alpha	446..491	CDD:214549	17/44 (39%)
		Integrin_alpha2	479..1006	CDD:285619	101/544 (19%)
Itga10	NP_001289400.1	Int_alpha	41..81	CDD:214549	17/48 (35%)
		vWA_integrins_alpha_subunit	166..346	CDD:238746	19/184 (10%)
		Int_alpha	482..532	CDD:214549	20/49 (41%)
		Int_alpha	545..599	CDD:214549	24/53 (45%)
		Integrin_alpha2	642..1049	CDD:285619	96/527 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832027
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840