DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itgax

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_067309.1	Gene:	Itgax / 16411	MGIID:	96609	Length:	1169	Species:	Mus musculus

Alignment Length:	1344	Identity:	306/1344 - (22%)
Similarity:	487/1344 - (36%)	Gaps:	453/1344 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LGILIILQCVLTCYNFNLEQRLPIVKYGHPH---SHFGYSVATHTIGEANGPNKTNCVLVGAPLD 80
            :..|::|..| :|..|||:..    |..|.|   :.||:||..:         .::.|:||||.:
Mouse     6 IAFLLLLGFV-SCLGFNLDAE----KLTHFHMDGAEFGHSVLQY---------DSSWVVVGAPKE 56

  Fly    81 QNRQPNTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQ 145
            ...   |...|.|::|  .....:||.:          .:..||  :.:.....:.:...:||
Mouse    57 IKA---TNQIGGLYKC--GYHTGNCEPI----------SLQVPP--EAVNISLGLSLAAATNP-- 102

  Fly   146 ANGSGGKVIVCAHRYMYIVRENRYGQGLCYLLTNDLQ---------------------------- 182
                 ..::.|.....:..|||.|..|||:||::..:
Mouse   103 -----SWLLACGPTVHHTCRENIYLTGLCFLLSSSFKQSQNFPTAQQECPKQDQDIVFLIDGSGS 162

  Fly   183 -----FEEVHEPCKG------RPVQR----QHEDY--------GLCQAGTSAALLDDDTMVLGSP 224
                 ||::.:..|.      ||..|    |..||        ......:..:||.....:.|
Mouse   163 ISSTDFEKMLDFVKAVMSQLQRPSTRFSLMQFSDYFRVHFTFNNFISTSSPLSLLGSVRQLRG-- 225

  Fly   225 GPYTWRGS--------IWVTQVG------------------GEYLQRDKT--------------- 248
              ||:..|        ::.||.|                  |:.|..|..
Mouse   226 --YTYTASAIKHVITELFTTQSGARQDATKVLIVITDGRKQGDNLSYDSVIPMAEAASIIRYAIG 288

  Fly   249 ---TYYSDHSD------LNSPVDKY---------------------------------------- 264
               .:|::||.      .:.|..:|
Mouse   289 VGKAFYNEHSKQELKAIASMPSHEYVFSVENFDALKDIENQLKEKIFAIEGTETPSSSTFELEMS 353

  Fly   265 --------------------------------------------------SYLGMSVTGGRFFGH 279
                                                              :|||.|.....:.|.
Mouse   354 QEGFSAVFTPDGPVLGAVGSFSWSGGAFLYPSNMRPTFINMSQENEDMRDAYLGYSTALAFWKGV 418

  Fly   280 MSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELATADINGDHRPDLI-VAAP 343
            .|...||||.:..|:||||.:.:.:..| .|.:.|.|.||.||..|.:.|::.|...||: :..|
Mouse   419 HSLILGAPRHQHTGKVVIFTQESRHWRP-KSEVRGTQIGSYFGASLCSVDMDRDGSTDLVLIGVP 482

  Fly   344 LYFTKTEGGAVYVYQNIQDTLPM-----KYTLKLT-----GPLESRFGLALANIGDLNKDNCEDL 398
            .|:..|.||.|.|       .||     ::....|     |....|||.||..:||:|.|:..|:
Mouse   483 HYYEHTRGGQVSV-------CPMPGVGSRWHCGTTLHGEQGHPWGRFGAALTVLGDVNGDSLADV 540

  Fly   399 AVGAP--YEGNGVVYIYLGSS-QGLNSKPAQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNS 460
            |:|||  .|..|.|||:.|:| |.:...|:|:|.||:    ||:  .|:.||.|:||..||..:.
Mouse   541 AIGAPGEEENRGAVYIFHGASRQDIAPSPSQRISASQ----IPS--RIQYFGQSLSGGQDLTRDG 599

  Fly   461 YPDVVIGAFNSSAAVILL-ARPIISIQTSVQRKELHNMDPNTPG--------CLDDPASNLTCFT 516
            ..|:.:|   |...|:|| .|||:.:..:|.         .||.        |.:..|...|...
Mouse   600 LVDLAVG---SKGRVLLLRTRPILRVSPTVH---------FTPAEISRSVFECQEQVAPEQTLSD 652

  Fly   517 FRACCSIEPYDEKNK----ELRLAYSVEAETFDHLKKFSRVFFFDRENKRTNVLSRVVRVHTNGR 577
            ...|..|.   |..|    :||...:.:. ..||.:..:|..|  :|.| |..|:||..:..|
Mouse   653 ATVCLHIH---ESPKTQLGDLRSTVTFDL-ALDHGRLSTRAIF--KETK-TRALTRVKTLGLN-- 708

  Fly   578 TECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSALVRLNPIL---DQTQAHVDFEGTFQKD 639
            ..|::|...:.|...|..||:..||.:|||..|:  |:|..|.|:|   |||......  .|:|:
Mouse   709 KHCESVKLLLPACVEDSVTPITLRLNFSLVGVPI--SSLQNLQPMLAVDDQTYFTASL--PFEKN 769

  Fly   640 CGDDDLCESNL-IIRVEPNITESSGNEYTLIL-DETELEVRINVSNLADSAYEAQLFIAHQAGVS 702
            ||.|.:|:.:| ::...|::.       ||:: .:.||.|.:.|||..:.:|...:.:.:..|:|
Mouse   770 CGADHICQDDLSVVFGFPDLK-------TLVVGSDLELNVDVTVSNDGEDSYGTTVTLFYPVGLS 827

  Fly   703 YVATKKPTNATCNSYNTTLVACSLGNPMLRDTTTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLV 767
            :....:                  |...||...   ..::|.:|...      .|:..::|
Mouse   828 FRRVAE------------------GQVFLRKKE---DQQWQRRGQHS------LHLMCDST---- 861

  Fly   768 GPERPERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGPMG-----MDDV 827
             |:|.:.....:...|..: |||          ||.:...|    ..|:.....:|     ...|
Mouse   862 -PDRSQGLWSTSCSSRHVI-FRG----------GSQMTFLV----TFDVSPKAELGDRLLLRARV 910

  Fly   828 GSQVHHMFTIFNEGPSTAPKVQMVIHWP--YSLYSDPQSGRPVQYLLYL-------EQVPTVEVS 883
            ||:        |..|.| ||....:..|  |::|:...|..  |:..||       |:...||
Mouse   911 GSE--------NNVPGT-PKTTFQLELPVKYAVYTMISSHD--QFTKYLNFSTSEKEKTSVVE-- 962

  Fly   884 QGECHVAKEYVNPLNLASGSRENPAYLS--APAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDD 946
                |  :..||.|    |.|:.|..::  .|.:::     ....:...:.|.|...
Mouse   963 ----H--RFQVNNL----GQRDVPVSINFWVPIELK-----GEAVWTVMVSHPQNPL-------- 1004

  Fly   947 HSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNM 1011
                ||..|||::.:..:.:|.:::   .|              .|||:  ..:|:.:.|||.::
Mouse  1005 ----TQCYRNRLKPTQFDLLTHMQK---SP--------------VLDCS--IADCLHLRCDIPSL 1046

  Fly  1012 PALSEAQVVVKARL---W-NSTLVSEYPRVERVRI-FSTAT-AQIPESYGVEVMDHNNIEVETRA 1070
            ..|.|...::|..|   | :.||..:...:....| |:|:. :|:|   |.|..    :..:|:.
Mouse  1047 GILDELYFILKGNLSFGWISQTLQKKVLLLSEAEITFNTSVYSQLP---GQEAF----LRAQTKT 1104

  Fly  1071 YPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKR 1114
            ..|:.....    |..:|:...||||||||::|.:|:|.|||||
Mouse  1105 VLEMYKVHN----PVPLIVGSSVGGLLLLAIITAILYKAGFFKR 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	16/65 (25%)
		Int_alpha	317..368	CDD:214549	18/56 (32%)
		Int_alpha	378..428	CDD:214549	24/52 (46%)
		Int_alpha	446..491	CDD:214549	17/45 (38%)
		Integrin_alpha2	479..1006	CDD:285619	122/559 (22%)
Itgax	NP_067309.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	23..78		17/72 (24%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	79..138		14/77 (18%)
		vWA_integrins_alpha_subunit	151..326	CDD:238746	26/178 (15%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	341..392		0/50 (0%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	393..444		15/50 (30%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	445..505		22/67 (33%)
		Int_alpha	455..505	CDD:214549	18/56 (32%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	508..566		24/57 (42%)
		Int_alpha	518..573	CDD:214549	24/54 (44%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	571..631		25/77 (32%)
		Integrin_alpha2	616..987	CDD:285619	109/469 (23%)
		Integrin_alpha	1138..1152	CDD:278771	6/7 (86%)
		GFFKR motif	1140..1144		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810