DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itgav

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_032428.2	Gene:	Itgav / 16410	MGIID:	96608	Length:	1044	Species:	Mus musculus

Alignment Length:	1177	Identity:	305/1177 - (25%)
Similarity:	509/1177 - (43%)	Gaps:	209/1177 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GILIILQCVL--TCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTN--CVLVGAPLD 80
            |:|::|..:|  ....|||:...|....|...|:||::|      :...|:.::  .:|||||..
Mouse    15 GLLLLLPGLLLPLADAFNLDVESPAEYAGPEGSYFGFAV------DFFEPSTSSRMFLLVGAPKA 73

  Fly    81 QNRQPNTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQ 145
            ...||.....|.:.:|..:.. ..|:.:..|...|.|.....|.   |.|..||.|.:|||..
Mouse    74 NTTQPGIVEGGQVLKCECSSS-RRCQPIEFDSTGNRDYAKDDPL---EFKSHQWFGASVRSKQ-- 132

  Fly   146 ANGSGGKVIVCAHRYMY--IVRENRYGQGLCYLLTNDLQFEEVHEPCKGRPVQRQHEDYGLCQAG 208
                 .|::.||..|.:  .:::.|...|.|:|.......|  :.||:.:.:..  :..|.||.|
Mouse   133 -----DKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVE--YAPCRSKNIDA--DGQGFCQGG 188

  Fly   209 TSAALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSD-----LNSPVDKYSYLG 268
            .|......|.::||.||.:.|:|.:...||.....:.|...|...:::     ....:...||||
Mouse   189 FSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIISKYDPNVYSIKYNNQLATRTAQAIFDDSYLG 253

  Fly   269 MSVTGGRFFGH--MSYAAGAPR-SEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELATADI 330
            .||..|.|.|.  ..:.:|.|| :...|.|.|:|..  |...:|: ..|||..:.||:.:|..||
Mouse   254 YSVAVGDFNGDGIEDFVSGVPRAARTLGMVYIYDGK--NMSSLHN-FTGEQMAAYFGFSVAATDI 315

  Fly   331 NGDHRPDLIVAAPLYFTKTEGGAV----YVYQNIQDTLPMKYTLKLTG-PLESRFGLALANIGDL 390
            |||...|:.:.|||:..:...|.:    .|..::|..:....|.||.| .:.:|||.|:|.:|||
Mouse   316 NGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRAVGDFQTTKLNGFEVFARFGSAIAPLGDL 380

  Fly   391 NKDNCEDLAVGAPYEG---NGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISISG 452
            ::|...|:|:.|||.|   .|:|||:.|.|.||||.|:|.::......::|     .:||.|:.|
Mouse   381 DQDGFNDIAIAAPYGGEDKKGLVYIFNGRSTGLNSVPSQILEGQWAAQSMP-----PSFGYSMKG 440

  Fly   453 NTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQ-RKELHNMDPNTPGCLDDPASNLTCFT 516
            .||:|.|.|||:|:|||....||:..|||::::...:: ...:.|.| |....|...|..::||.
Mouse   441 ATDVDRNGYPDLVVGAFGVDRAVLYRARPVVTVNAGLEVYPSILNQD-NKICPLPGTALKVSCFN 504

  Fly   517 FRACCSIEPYDEKNKELRLAYSVEAETFDHLKK---FSRVFFFDRENKRTNVLSRVVRVHTNGRT 578
            .|.|...:  .:.....:|.:.||. ..|.||:   ..|..|.   :.|:.|.|:.:.|...|:.
Mouse   505 VRFCLKAD--GKGTLPRKLHFQVEL-LLDKLKQKGAIRRALFL---HNRSPVHSKTMTVFRGGQM 563

  Fly   579 ECQAVTGYIK--ANTRDIQTPVRFRLKYSLVEPPLADSALVRLNPILDQ-TQAHVDFEGTFQKDC 640
            :|:.:..|::  :..||..||:...::|.|.:...||:  ..|.|||:| |.|:|..:.....||
Mouse   564 QCEELVAYLRDESEFRDKLTPITIFMEYRLDQRTAADA--TGLQPILNQFTPANVSRQAHILLDC 626

  Fly   641 GDDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRINVSNLADSAYEAQLFIAHQAGVSYVA 705
            |:|::|:..|.:.|      :|..:...|.|:..|.:.:...|..:.||||:|.::......::.
Mouse   627 GEDNVCKPKLEVSV------NSDQKKIYIGDDNPLTLTVKAQNQGEGAYEAELIVSIPPQADFIG 685

  Fly   706 TKKPTNA----TC---NSYNTTLVACSLGNPMLRDTTTFVTIRF---QPKGLEPSE----KIMLF 756
            ..:...|    :|   ....|..|.|.|||||...|.....:||   |...::.|.    ||...
Mouse   686 VVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLKIQSS 750

  Fly   757 HIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGP 821
            :.|.|.:        |....:|::...|.:..||.:.|:..|.       .:.|....:    .|
Mouse   751 NSFDNVS--------PVVSYKVDLAVLAAVEIRGVSSPDHIFL-------PIPNWEYKE----NP 796

  Fly   822 MGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGE 886
            ...:|||..|.|::.:.|.|||:..|..:.:.|||...::.        |||:
Mouse   797 ETEEDVGPIVQHIYELRNNGPSSFSKAILNLQWPYKYNNNT--------LLYI------------ 841

  Fly   887 CHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDT 951
              :..:...|:|..:.:..||..:..|                             .::|.:...
Mouse   842 --LHYDIDGPMNCTADTEINPLRIKTP-----------------------------EKNDTAAAG 875

  Fly   952 QSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNMPALSE 1016
            |..||.:       :|:.:..:           ::.|:..|.|  |...|::|.|.:..:.....
Mouse   876 QGERNHL-------ITKRDLTL-----------REGDVHTLGC--GIAKCLQITCQVGRLDRGKS 920

  Fly  1017 AQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYPELRN----- 1076
            |.:.||:.||..|.:::..:.....:.|:|      |:.:....:.|:.:|     :|.|
Mouse   921 AILYVKSLLWTETFMNKENQNHSYSLKSSA------SFNIIEFPYKNLPIE-----DLFNSTLVT 974

  Fly  1077 -------QQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGNLEKMNEEKP 1134
                   |.....:|..:|||.::.||||||::.:|::::|||||:||         .:..:|:.
Mouse   975 TNITWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRP---------PQEEQERE 1030

  Fly  1135 FLAPSKN 1141
            .|.|.:|
Mouse  1031 QLQPHEN 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	15/64 (23%)
		Int_alpha	317..368	CDD:214549	15/54 (28%)
		Int_alpha	378..428	CDD:214549	27/52 (52%)
		Int_alpha	446..491	CDD:214549	20/45 (44%)
		Integrin_alpha2	479..1006	CDD:285619	120/547 (22%)
Itgav	NP_032428.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	32..98		18/72 (25%)
		Int_alpha	46..103	CDD:214549	15/63 (24%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	109..170		19/72 (26%)
		WD40 repeat	126..183	CDD:293791	14/67 (21%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	173..225		14/53 (26%)
		WD40 repeat	188..248	CDD:293791	13/59 (22%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	237..291		16/55 (29%)
		Int_alpha	248..>288	CDD:214549	15/39 (38%)
		WD40 repeat	254..298	CDD:293791	14/46 (30%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	292..357		19/65 (29%)
		Int_alpha	302..355	CDD:214549	15/52 (29%)
		WD40 repeat	307..362	CDD:293791	16/54 (30%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	358..415		27/56 (48%)
		Int_alpha	367..421	CDD:214549	27/53 (51%)
		WD40 repeat	371..422	CDD:293791	25/50 (50%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	419..482		22/67 (33%)
		Int_alpha	434..476	CDD:214549	20/41 (49%)
		Integrin_alpha2	467..910	CDD:285619	120/547 (22%)
		GFFKR motif	1015..1019		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1023..1044		4/15 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832019
Domainoid	1	1.000	54	1.000	Domainoid score	I11158
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750