DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itgal

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001240801.1	Gene:	Itgal / 16408	MGIID:	96606	Length:	1162	Species:	Mus musculus

Alignment Length:	1395	Identity:	290/1395 - (20%)
Similarity:	470/1395 - (33%)	Gaps:	531/1395 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ILIILQCVLTCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNRQP 85
            :|:.||.....:::||:.|...........||||.|.....|          |:||||.:.:
Mouse    11 LLLGLQLFAKAWSYNLDTRPTQSFLAQAGRHFGYQVLQIEDG----------VVVGAPGEGD--- 62

  Fly    86 NTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQANGSG 150
               ::|.|:.|..:..|  |:.|...|..:               ..:::|:|     |..:.:.
Mouse    63 ---NTGGLYHCRTSSEF--CQPVSLHGSNH---------------TSKYLGMT-----LATDAAK 102

  Fly   151 GKVIVCAHRYMYIVRENRYGQGLCYLLTNDLQ--------------------------------- 182
            |.::.|.........:|.|..|||||....|:
Mouse   103 GSLLACDPGLSRTCDQNTYLSGLCYLFPQSLEGPMLQNRPAYQECMKGKVDLVFLFDGSQSLDRK 167

  Fly   183 -FEEVHEPCKG--RPVQRQHEDYGLCQAGTSA----ALLD------DDTMVLGSPGPY-----TW 229
             ||::.|..|.  |.:......:...|..|..    ..||      :..::|||..|.     |:
Mouse   168 DFEKILEFMKDVMRKLSNTSYQFAAVQFSTDCRTEFTFLDYVKQNKNPDVLLGSVQPMFLLTNTF 232

  Fly   230 R-----------------------------------GSI--------WVTQVGGEY--LQRDKTT 249
            |                                   |:|        ::..:|..:  :|:.||.
Mouse   233 RAINYVVAHVFKEESGARPDATKVLVIITDGEASDKGNISAAHDITRYIIGIGKHFVSVQKQKTL 297

  Fly   250 YYSDHSDLNSPVDKYSYL----------------------------------------------- 267
                |...:.||:::..:
Mouse   298 ----HIFASEPVEEFVKILDTFEKLKDLFTDLQRRIYAIEGTNRQDLTSFNMELSSSGISADLSK 358

  Fly   268 GMSVTG--------GRFF-----------------------GHMSY--------------AAGAP 287
            |.:|.|        |.|.                       |::.|              |||||
Mouse   359 GHAVVGAVGAKDWAGGFLDLREDLQGATFVGQEPLTSDVRGGYLGYTVAWMTSRSSRPLLAAGAP 423

  Fly   288 RSEGHGQVVIFD--------KSTDNPIPVHSILDGEQFGSSFGYELATADINGDHRPD-LIVAAP 343
            |.:..|||::|.        ..|..       ::|.|.||.||.||.:.|::.|...: |::.||
Mouse   424 RYQHVGQVLLFQAPEAGGRWNQTQK-------IEGTQIGSYFGGELCSVDLDQDGEAELLLIGAP 481

  Fly   344 LYFTKTEGGAVYVYQNIQDTLPMKYTLKLTG----PLESRFGLALANIGDLNKDNCEDLAVGAPY 404
            |:|.:..||.|:.||..|....|  ..:|.|    || .|||.|:..:.|:|.|...|:|||||.
Mouse   482 LFFGEQRGGRVFTYQRRQSLFEM--VSELQGDPGYPL-GRFGAAITALTDINGDRLTDVAVGAPL 543

  Fly   405 EGNGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAF 469
            |..|.|||:.|...||:.:|:|:||.:::   .|.   ||.||.||.|..||..:...|||:||
Mouse   544 EEQGAVYIFNGKPGGLSPQPSQRIQGAQV---FPG---IRWFGRSIHGVKDLGGDRLADVVVGA- 601

  Fly   470 NSSAAVILLARPIISIQTSVQRKELHNMDPNTPGCLDDPASNLTC-----------FTFRACCSI 523
             ....|:|.:||::.:.|.:      :..|.     :.|...:.|           ...:||..|
Mouse   602 -EGRVVVLSSRPVVDVVTEL------SFSPE-----EIPVHEVECSYSAREEQKHGVKLKACFRI 654

  Fly   524 EPYDEKNKE---LRLAYSVEAETFDHLKKFSRVFFFDRENKRTNVLSRVVRVHTNGRT------E 579
            :|...:.:.   ..|:|:::   .|..:..||..|.|..::            .:|.|      .
Mouse   655 KPLTPQFQGRLLANLSYTLQ---LDGHRMRSRGLFPDGSHE------------LSGNTSITPDKS 704

  Fly   580 CQAVTGYIKANTRDIQTPVRFRLKYSLVE---PPLADSALVRLNPILDQTQAHVDFEGTFQKDCG 641
            |.....:.....:|:.:|:...|.:||:|   .|........:.|||..:...|..|..|:|:||
Mouse   705 CLDFHFHFPICIQDLISPINVSLNFSLLEEEGTPRDQKVGRAMQPILRPSIHTVTKEIPFEKNCG 769

  Fly   642 DDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRINVSNLADSAYEAQLFIAHQAGVSY--V 704
            :|..||:||      .::..:.:....::....|.|...:||..:.||..:|.:....|:|:  |
Mouse   770 EDKKCEANL------TLSSPARSGPLRLMSSASLAVEWTLSNSGEDAYWVRLDLDFPRGLSFRKV 828

  Fly   705 ATKKPTN---ATC------NSYNTTLVACSLGNPMLRDTTTFVTIRFQPKGLEPSEKIMLFHIFA 760
            ...:|.:   .:|      :|..|..:.|::.:|:.:            .|.|.|.::| |:...
Mouse   829 EMLQPHSRMPVSCEELTEGSSLLTKTLKCNVSSPIFK------------AGQEVSLQVM-FNTLL 880

  Fly   761 NTT----SKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGP 821
            |::    .:|.|....|.:                         .||:...  |:|||.|....|
Mouse   881 NSSWEDFVELNGTVHCENE-------------------------NSSLQED--NSAATHIPVLYP 918

  Fly   822 MGM---DDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVS 883
            :.:   :...|.::..||      ...||.|.|.| .|.:...|.:        |...:||:|
Mouse   919 VNILTKEQENSTLYISFT------PKGPKTQQVQH-VYQVRIQPSA--------YDHNMPTLE-- 966

  Fly   884 QGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSY-YSSSHRDD- 946
                                    |.:..|     :|            ||:... |:.|.:.|
Mouse   967 ------------------------ALVGVP-----WP------------HSEDPITYTWSVQTDP 990

  Fly   947 ----HSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECD 1007
                ||:|.:...:...:..|..|.....:::..|......|    .|||.....|::.:.: |.
Mouse   991 LVTCHSEDLKRPSSEAEQPCLPGVQFRCPIVFRREILIQVTG----TVELSKEIKASSTLSL-CS 1050

  Fly  1008 ILNM------------PALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMD 1060
            .|::            ...|||||:||.     .|:.|                       :.|.
Mouse  1051 SLSVSFNSSKHFHLYGSKASEAQVLVKV-----DLIHE-----------------------KEML 1087

  Fly  1061 HNNIEVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGN 1125
            |                         :.:|..:|||:||.|:...|:|||||||          |
Mouse  1088 H-------------------------VYVLSGIGGLVLLFLIFLALYKVGFFKR----------N 1117

  Fly  1126 L-EKM------------NEEKPFLAPSKNT 1142
            | |||            .:..|...|.:.|
Mouse  1118 LKEKMEADGGVPNGSPPEDTDPLAVPGEET 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	17/62 (27%)
		Int_alpha	317..368	CDD:214549	20/51 (39%)
		Int_alpha	378..428	CDD:214549	23/49 (47%)
		Int_alpha	446..491	CDD:214549	17/44 (39%)
		Integrin_alpha2	479..1006	CDD:285619	107/573 (19%)
Itgal	NP_001240801.1	FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	444..504		22/66 (33%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	505..561		25/56 (45%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	565..625		23/73 (32%)
		GFFKR motif	1112..1116		3/3 (100%)
		FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	28..79		17/68 (25%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	80..138		15/77 (19%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	336..387		5/50 (10%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	390..443		12/52 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832048
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740