DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itgae

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_032425.2	Gene:	Itgae / 16407	MGIID:	1298377	Length:	1167	Species:	Mus musculus

Alignment Length:	988	Identity:	235/988 - (23%)
Similarity:	393/988 - (39%)	Gaps:	264/988 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 LTNDLQFEEVH-EPCKGRPVQRQHEDYGLCQAGTSAALLDDDTMVLGSPGPYTWRGS--IWVTQV 238
            |.:.||...|| |...|..:|     |.|.|.|.||.:||...::||:.|.:.|.|.  ::.||.
Mouse   371 LLSKLQQHIVHMEGTVGDALQ-----YQLAQTGFSAQILDKGQVLLGTVGAFNWSGGALLYSTQN 430

  Fly   239 GGEYLQRDKTTYYSDHSDLNSPVDKYSYLGMSVTGGRFFGHMSYAAGAPRSEGHGQVVIFDKSTD 303
            |       :..:.:..:..:|...:|||||.|:........:||.|||||.:..|.|....|...
Mouse   431 G-------RGCFLNQTAKEDSRTVQYSYLGYSLAVLHKAHGVSYVAGAPRHKLRGAVFELRKEDR 488

  Fly   304 NPIPVHSILDGEQFGSSFGYELATADINGDHRPD-LIVAAPLYFTKTEGGAVYVYQ-NIQD-TLP 365
            ........::|||.||.||..|...||:.|...| |:||||.|..:.|.|.||||| ..|| :..
Mouse   489 EEDAFVRRIEGEQMGSYFGSVLCPVDIDMDGTTDFLLVAAPFYHIRGEEGRVYVYQVPEQDASFS 553

  Fly   366 MKYTLK-LTGPLESRFGLALANIGDLNKDNCEDLAVGAPYEGNGV--------VYIYLGSSQGLN 421
            :.:||. ..|...||||.|:|.:||:|:|...|:|:|||.||.|.        ||||.|.|.||.
Mouse   554 LAHTLSGHPGLTNSRFGFAMAAVGDINQDKFTDVAIGAPLEGFGAGDGASYGSVYIYNGHSGGLY 618

  Fly   422 SKPAQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQ 486
            ..|:|:|:||    ::.:|  :..||:|:||..|.:.:...|:.:|:.:|  ||:|.:||::.:.
Mouse   619 DSPSQQIRAS----SVASG--LHYFGMSVSGGLDFNGDGLADITVGSRDS--AVVLRSRPVVDLT 675

  Fly   487 TSVQRKELHNMDPNTPGCLDDPASNLTCFTFRACCSIEPYDEKN----KELRLAYSVEAETFDHL 547
            .|:         ..||..|  |...:.....:.|..::.....:    :|:.|.::|:.   |..
Mouse   676 VSM---------TFTPDAL--PMVFIGKMDVKLCFEVDSSGVASEPGLREMFLNFTVDV---DVT 726

  Fly   548 KKFSRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANTRD-----------IQTPVRFR 601
            |:..|:...|....::     .:|....|...|:   .:...:|.:           |:....|:
Mouse   727 KQRQRLQCEDSSGCQS-----CLRKWNGGSFLCE---HFWLISTEELCEEDCFSNITIKVTYEFQ 783

  Fly   602 LKYSLVEPPLADSALVRLNPILDQ-TQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNE 665
            ......:.|         ||.||. .:....|:..::|||.:...|.:.  |::..||::..
Mouse   784 TSGGRRDYP---------NPTLDHYKEPSAIFQLPYEKDCKNKVFCIAE--IQLTTNISQQE--- 834

  Fly   666 YTLILDET-ELEVRINVSNLADSAYEAQLFIAHQAGVSYVATKKPT--NATCNS----YNTTLVA 723
              |::..| |:.:.|:::|..:.:|...:.:.:...:.:...:||.  :..|:.    .:..::.
Mouse   835 --LVVGVTKEVTMNISLTNSGEDSYMTNMALNYPRNLQFKKIQKPVSPDVQCDDPKPVASVLVMN 897

  Fly   724 CSLGNPMLRDTTTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNF 788
            |.:|:|:|:.::..|::.:|   ||.|       :|.|.|:          |:.|
Mouse   898 CKIGHPILKRSSVNVSVTWQ---LEES-------VFPNRTA----------DITV---------- 932

  Fly   789 RGWAIPEQSFYSGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIH 853
                          :::||...:.|.:..          ..|..|.|......||
Mouse   933 --------------TISNSNEKSLARETR----------SLQFRHAFIAVLSRPS---------- 963

  Fly   854 WPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEY---VNPLNLASGSRENPAYLSAPAQ 915
                          |.| :...|.|:..         ||:   |:..||          ..|..|
Mouse   964 --------------VMY-MNTSQSPSDH---------KEFFFNVHGENL----------FGAVFQ 994

  Fly   916 MRMFPSQSRHSFN----KSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDP 976
            :::........|.    |:|..:|          ||::.|||.........::.|.....::.
Mouse   995 LQICVPIKLQDFQIVRVKNLTKTQ----------DHTECTQSQEPACGSDPVQHVKEWHSVVC-- 1047

  Fly   977 ESSNAANGKKQDI-VELDCNKGATNCVRIECDILNMPALSEAQVVVKARLWNSTLV----SEYPR 1036
                |....|::: |..:.:.|.|.  ::..|:..:|.|.|..       :|.:|.    :|..|
Mouse  1048 ----AITSNKENVTVAAEISVGHTK--QLLRDVSELPILGEIS-------FNKSLYEGLNAENHR 1099

  Fly  1037 VERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLAL 1101
            .:...||..                   |.|||:.|              :||...:||||:|.:
Mouse  1100 TKITVIFLK-------------------EEETRSLP--------------LIIGSSIGGLLVLVV 1131

  Fly  1102 VTYVLWKVGFFKR 1114
            :..:|:|.|||||
Mouse  1132 IIAILFKCGFFKR 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549
		Int_alpha	317..368	CDD:214549	24/53 (45%)
		Int_alpha	378..428	CDD:214549	28/57 (49%)
		Int_alpha	446..491	CDD:214549	15/44 (34%)
		Integrin_alpha2	479..1006	CDD:285619	91/557 (16%)
Itgae	NP_032425.2	FG-GAP 1	27..81
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	84..142
		X-domain (extra domain)	149..192
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..191
		vWA_integrins_alpha_subunit	196..371	CDD:238746	235/988 (24%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	383..435		19/63 (30%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	438..491		17/52 (33%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	492..552		27/59 (46%)
		Int_alpha	502..558	CDD:214549	24/55 (44%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	555..619		29/63 (46%)
		Int_alpha	566..625	CDD:214549	28/58 (48%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	623..683		21/76 (28%)
		Int_alpha	636..>659	CDD:214549	7/22 (32%)
		Integrin_alpha2	668..>939	CDD:285619	59/352 (17%)
		GFFKR motif	1140..1144		3/3 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832034
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D743479at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750