Protein Alignment mew and Itga7

DIOPT Version :10

• Sequence 1: NP_001285196.1
• Gene: mew / 32275
• FlyBaseID: FBgn0004456
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: XP_030100775.1
• Gene: Itga7 / 16404
• MGIID: 102700
• Length: 1180
• Species: Mus musculus
• Alignment Length: 1268
• Identity: 359/1268 - (28%)
• Similarity: 551/1268 - (43%)
• Gaps: 310/1268 - (24%)

  Fly    11 PNCRLRQNLGILIILQCVLT------CYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNK 69
            |.|...:..||..::..:|.      ...|||:....|.|.|.|.|.||:|||.|   ....|..
Mouse     5 PRCDFLRPPGIYYLITSLLAGLFLPPAIAFNLDVMGAIRKEGEPGSLFGFSVALH---RQLQPRP 66

  Fly    70 TNCVLVGAPLD---QNRQPNTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKE 131
            .:.:|||||..   ..:|.|.|  |.|:.||::....||.:|..|...|...         |.||
Mouse    67 QSWLLVGAPQALALPGQQANRT--GGLFACPLSLEETDCYRVDIDRGANVQK---------ESKE 120

  Fly   132 DQWMGVTVRSNPLQANGSGGKVIVCAHRYMYIVR-----ENRYGQGLCYLLTNDLQFEEVHEP-- 189
            :||:||:|||     .|.|||::.|||||....|     |.|...|.|::|:.||...:..:.
Mouse   121 NQWLGVSVRS-----QGPGGKIVTCAHRYESRQRVDQALETRDVIGRCFVLSQDLAIRDELDGGE 180

  Fly   190 ---CKGRPVQRQHEDYGLCQAGTSAALL-DDDTMVLGSPGPYTWRGSIWVT-------------- 236
               |:|||  :.||.:|.||.||:|... |...:|.|:||.|.|:|:..|.
Mouse   181 WKFCEGRP--QGHEQFGFCQQGTAATFSPDSHYLVFGAPGTYNWKGTARVELCAQGSPDLAHLDD 243

  Fly   237 ---QVGGEYLQRDK------TTYYS-------DHSDLN-------SPVDKY----------SYLG 268
               :.|||..|..:      .:|..       |.||.:       .|.|:.          ||||
Mouse   244 GPYEAGGEKEQDPRLIPVPANSYLGLLFVTNIDSSDPDQLVYKTLDPADRLTGPAGDLTLNSYLG 308

  Fly   269 MSVTGGRFF---GHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELATADI 330
            .|:..|:..   ..:|:.|||||:...|.|||..|.:.:.:....:|.||:..|.|||.||..|:
Mouse   309 FSIDSGKGLMRSEELSFVAGAPRANHKGAVVILRKDSASRLIPEVVLSGERLTSGFGYSLAVTDL 373

  Fly   331 NGDHRPDLIVAAPLYFTKTE--GGAVYVYQN----IQDTLPMKYTLKLTGPLESRFGLALANIGD 389
            |.|...||||.||.:|.:.|  |||||||.|    ..|..|    |::.|..:|.||::||.:||
Mouse   374 NNDGWADLIVGAPYFFERQEELGGAVYVYMNQGGHWADISP----LRICGSPDSMFGISLAVLGD 434

  Fly   390 LNKDNCEDLAVGAPYEGNGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISISGNT 454
            ||:|...|:|||||::|:|.|:||.|||.|:..||:|.::...:|        |::||.|:||..
Mouse   435 LNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVVKPSQVLEGEAVG--------IKSFGYSLSGGL 491

  Fly   455 DLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPNT-----PGCLDDPASNLTC 514
            |:|.|.|||:::|:...:|| :..|||::.:...:      .:||..     |.|.|   ..|.|
Mouse   492 DVDGNHYPDLLVGSLADTAA-LFRARPVLHVSQEI------FIDPRAIDLEQPNCAD---GRLVC 546

  Fly   515 FTFRACCS-IEPYDEKNKELRLAYSVEAETFDHLK-KFSRVFFFDR--ENKRTNVLSRVVRVHTN 575
            ...:.|.| :......:..:.|.|.::.:|...|: :..||.|..|  ::.|......|...|.:
Mouse   547 VDIKICFSYVAVPSSYSPSVALDYMLDGDTDRRLRGQVPRVTFLSRGLDDLRHQSSGTVWLKHQH 611

  Fly   576 GRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSA----LVRLNPILD-------QTQAH 629
            .|. |......::.|.:|....:...|.|.|..|||...|    |..:.|||:       :|:.|
Mouse   612 DRV-CGDTVFQLQENVKDKLRAIVVTLSYGLRTPPLGRQAPGQELPTVAPILNAHQPSTQRTEIH 675

  Fly   630 VDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLI---LD----------ETELEVRINV 681
            .     .::.||:|.:|:|||.:......:..|..|:..:   ||          :..:.:.:.|
Mouse   676 F-----LKQGCGEDKICQSNLQLERYQFCSRISDTEFQALPMDLDGRTALFALSGQPFIGLELTV 735

  Fly   682 SNL----------ADSAYEAQLFIAHQAGVSYV------ATKKPTNATCNSYNT-TLVACSLGNP 729
            :||          .|.|:||||.:...|.:.|.      :.:||   .|.|.:: :.|.|.||||
Mouse   736 TNLPSDPARPQADGDDAHEAQLLVTLPASLRYSGVRALDSVEKP---LCLSNDSASHVECELGNP 797

  Fly   730 MLR--DTTTFVTIRFQPKGLEPSE---KIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFR 789
            |.|  ..|.::.:......:|.:|   |::|    |..:.:.:.|.    .:|.:|.....|:..
Mouse   798 MKRGAQVTFYLILSTSGITIETTELEVKLLL----ATISEQELDPV----SVRAHVFIELPLSIS 854

  Fly   790 GWAIPEQSFYSGSSVANSVANTAATDIEGHGPMGMD-DVGSQVHHMFTIFNEGPS--TAPKVQMV 851
            |.|.|:|.|:||             :::|...|..: ||||:|.:..|:.|:|.|  |.....:.
Mouse   855 GVATPQQLFFSG-------------EVKGESAMRSERDVGSKVKYEVTVSNQGQSLNTLGSAFLN 906

  Fly   852 IHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQM 916
            |.||:.:.:.       ::|||..:   ||:..|:....:...:|       |.|...|..
Mouse   907 IMWPHEIANG-------KWLLYPMR---VELEGGQGPGKRGICSP-------RPNILQLDV---- 950

  Fly   917 RMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESS-- 979
                                                .:|:|.||...:...:......:|.:|
Mouse   951 ------------------------------------DSRDRRRRELGQPEPQEPPEKVEPSTSWW 979

  Fly   980 NAANGKKQDIVELDCNKGATNCVRIECDILNMPALSEAQVV-VKARLWNSTLVSEYPRVERVRIF 1043
            ..::.:|:: |.|||.:|...||...|.:.   :...|.|: |..||||||.:.||..|:
Mouse   980 PVSSAEKRN-VTLDCAQGTAKCVVFSCPLY---SFDRAAVLHVWGRLWNSTFLEEYMAVK----- 1035

  Fly  1044 STATAQIPESYGVEVMDHNNIEVETRAYPELRN-QQRDTS------------------IPWLIII 1089
                       .:||:...||.|::    .::| ..||.|                  :||.:|:
Mouse  1036 -----------SLEVIVRANITVKS----SIKNLLLRDASTVIPVMVYLDPMAVVVEGVPWWVIL 1085

  Fly  1090 LGIVGGLLLLALVTYVLWKVGFFKRIRPTDPTL 1122
            |.::.|||:|||:..:|||:|||||.:..:.|:
Mouse  1086 LAVLAGLLVLALLVLLLWKLGFFKRAKHPEATV 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	24/65 (37%)
		Int_alpha	317..368	CDD:214549	27/56 (48%)
		Int_alpha	378..428	CDD:214549	28/49 (57%)
		Int_alpha	446..491	CDD:214549	17/44 (39%)
		Integrin_alpha2	480..1006	CDD:462478	129/585 (22%)
Itga7	XP_030100775.1	Int_alpha	48..109	CDD:214549	24/65 (37%)
		Int_alpha	304..355	CDD:214549	17/50 (34%)
		Int_alpha	362..415	CDD:214549	27/56 (48%)
		Int_alpha	421..473	CDD:214549	28/51 (55%)
		Int_alpha	483..>523	CDD:214549	17/40 (43%)
		Integrin_alpha2	516..1005	CDD:462478	129/585 (22%)