DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mew and Itga6

DIOPT Version :9

Sequence 1:NP_001285196.1 Gene:mew / 32275 FlyBaseID:FBgn0004456 Length:1243 Species:Drosophila melanogaster
Sequence 2:NP_001264899.1 Gene:Itga6 / 16403 MGIID:96605 Length:1091 Species:Mus musculus


Alignment Length:1270 Identity:349/1270 - (27%)
Similarity:551/1270 - (43%) Gaps:319/1270 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 CRLRQNLGILIILQCVLTCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGA 77
            |.|..:.|:|..|.   |.:|.:..:...|.|.|.|.|.||:|:|.|...:   |.....:||||
Mouse     8 CLLYLSAGLLARLG---TAFNLDTREDNVIRKSGDPGSLFGFSLAMHWQLQ---PEDKRLLLVGA 66

  Fly    78 PLDQN---RQPNTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTV 139
            |..:.   ::.|.|  |.|:.|.:|.| ..|.::..|.    |::.:|     |.||||||||||
Mouse    67 PRAEALPLQRANRT--GGLYSCDITSR-GPCTRIEFDN----DADPMS-----ESKEDQWMGVTV 119

  Fly   140 RSNPLQANGSGGKVIVCAHRY-----MYIVRENRYGQGLCYLLTNDLQFEEVHEP-----CKGRP 194
                 |:.|.||||:.|||||     :...:|:|...|.||:|:.:|:.|:..:.     |.|| 
Mouse   120 -----QSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGR- 178

  Fly   195 VQRQHEDYGLCQAGTSAALLDD-DTMVLGSPGPYTWRGSIWVTQ-----------------VGGE 241
             .|.||.:|.||.|.:|....| ..:|.|:||.|.|:|.:.|.|                 ||||
Mouse   179 -LRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGE 242

  Fly   242 YLQRDKTTYYSDHSDLNSPVDKYSYLGMSVTGGRFF---GHMSYAAGAPRSEGHGQVVIF--DKS 301
                      :||.:...||...||||.|:..|:..   ..:::.:||||:...|.||:.  |..
Mouse   243 ----------TDHDESLVPVPANSYLGFSLDSGKGIVSKDDITFVSGAPRANHSGAVVLLKRDMK 297

  Fly   302 TDNPIPVHSILDGEQFGSSFGYELATADINGDHRPDLIVAAPLYFTK--TEGGAVYVYQNIQDTL 364
            :.:.:|.: |.|||...|||||::|..|:|.|...|:::.||.||.:  ..|||||||.|.|...
Mouse   298 SAHLLPEY-IFDGEGLASSFGYDVAVVDLNADGWQDIVIGAPQYFDRDGEVGGAVYVYINQQGKW 361

  Fly   365 PMKYTLKLTGPLESRFGLALANIGDLNKDNCEDLAVGAPYEGNGVVYIYLGSSQGLNSKPAQKIQ 429
            .....::|.|..:|.||:::.||||:|:|...|:||||||:..|.|:||.||..|:.:||.|.::
Mouse   362 SNVKPIRLNGTKDSMFGISVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSPTGIITKPTQVLE 426

  Fly   430 ASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKEL 494
                 ||.|      .||.||:||.|||.|||||:.:|:. |.:..|..:||:|:|..::     
Mouse   427 -----GTSP------YFGYSIAGNMDLDRNSYPDLAVGSL-SDSVTIFRSRPVINILKTI----- 474

  Fly   495 HNMDPNTPGCLD--------DPASNLTCFTFRACCSIEPYDEK----NKELRLAYSVEAETFDHL 547
                ..||..:|        .|:.  .|...:||..   |..|    |..:.:...:|||     
Mouse   475 ----TVTPNRIDLRQKSMCGSPSG--ICLKVKACFE---YTAKPSGYNPPISILGILEAE----- 525

  Fly   548 KKFSRVFFFDRENKRTNVLSRV--------------VRVHTNGRTECQAVTGYIKANTRDIQTPV 598
                      :|.:::.:.|||              :.::...:..|...|.:::.|.||...|:
Mouse   526 ----------KERRKSGLSSRVQFRNQGSEPKYTQELTLNRQKQRACMEETLWLQENIRDKLRPI 580

  Fly   599 RFRLKYSLVEPPLADSALVRLN------PILD-------QTQAHVDFEGTFQKDCGDDDLCESNL 650
            .......:.||    |:..|:|      |||:       ||..|...||     ||||::|.|||
Mouse   581 PITASVEIQEP----SSRRRVNSLPEVLPILNSNEAKTVQTDVHFLKEG-----CGDDNVCNSNL 636

  Fly   651 IIRVEPNITESSGNEYT----------LIL-DETELEVRINVSNL----------ADSAYEAQLF 694
            .:..:....|.:.::::          |:| |:.::.:.|.|:|.          .|.|:||:|.
Mouse   637 KLEYKFGTREGNQDKFSYLPIQKGIPELVLKDQKDIALEITVTNSPSDPRNPRKDGDDAHEAKLI 701

  Fly   695 IAHQAGVSYVA-------TKKPTNATCNSYNTTLVACSLGNPMLRD---------TTTFVTIRFQ 743
            ......::|.|       .:|..:...|. |.:...|.||||..|:         :||.||  |.
Mouse   702 ATFPDTLTYSAYRELRAFPEKQLSCVANQ-NGSQADCELGNPFKRNSSVTFYLILSTTEVT--FD 763

  Fly   744 PKGLEPSEKIMLFHIFANTTSKLVGPERPERDLRVNVVRRAK------LNFRGWAIPEQSFYSGS 802
            ...|:.:.|:       .|||        .:|....:..:||      |:..|.|.|.|.::.|:
Mouse   764 TTDLDINLKL-------ETTS--------NQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGT 813

  Fly   803 SVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGP-----STAPKVQMVIHWPYSLYSDP 862
            .|......:.            |:|||.:.:.|.:.|.|.     .||   .:.|.||..:    
Mouse   814 VVGEQAMKSE------------DEVGSLIEYEFRVINLGKPLKNLGTA---TLNIQWPKEI---- 859

  Fly   863 QSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNL--ASGSRENPAYLSAPAQMRMFPSQSRH 925
            .:|:   :||||.:|.:..:.|..|....| :|.|.|  :..||:.          |..|.:...
Mouse   860 SNGK---WLLYLMKVESKGLEQIVCEPHNE-INYLKLKESHNSRKK----------RELPEKQID 910

  Fly   926 SFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIV 990
            ...|..:..:|.|.:                                                  
Mouse   911 DSRKFSLFPERKYQT-------------------------------------------------- 925

  Fly   991 ELDCNKGATNCVRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYG 1055
             |:|:.. ..||.|.|.:..:.  |:|.:|:::||||||.:.||.::..:.|...|:..:..:..
Mouse   926 -LNCSVN-VRCVNIRCPLRGLD--SKASLVLRSRLWNSTFLEEYSKLNYLDILLRASIDVTAAAQ 986

  Fly  1056 VEVMDHNNIEVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDP 1120
            ...:.|...:|....:|. :...:.:.:.|.||:|.::.|:|:|||:.::|||.|||||.|..|.
Mouse   987 NIKLPHAGTQVRVTVFPS-KTVAQYSGVAWWIILLAVLAGILMLALLVFLLWKCGFFKRSRYDDS 1050

  Fly  1121 TLSGNLEKMNEEKPFLAPSKNTHHVFXQEGTVGWD 1155
            ....:..::.:|:..:...|:..::..::....|:
Mouse  1051 IPRYHAVRIRKEEREIKDEKHMDNLEKKQWITKWN 1085

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mewNP_001285196.1 Int_alpha 48..111 CDD:214549 21/65 (32%)
Int_alpha 317..368 CDD:214549 23/52 (44%)
Int_alpha 378..428 CDD:214549 26/49 (53%)
Int_alpha 446..491 CDD:214549 21/44 (48%)
Integrin_alpha2 479..1006 CDD:285619 127/615 (21%)
Itga6NP_001264899.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 30..95 23/70 (33%)
Int_alpha 40..100 CDD:214549 21/65 (32%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 101..166 32/78 (41%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 176..229 20/54 (37%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 244..300 18/55 (33%)
Int_alpha 254..>292 CDD:214549 13/37 (35%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 301..363 28/62 (45%)
Int_alpha 314..359 CDD:214549 22/44 (50%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 364..419 25/54 (46%)
Int_alpha 374..425 CDD:214549 26/50 (52%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 420..479 28/79 (35%)
Int_alpha 431..>454 CDD:214549 14/22 (64%)
Integrin_alpha2 464..939 CDD:369878 127/615 (21%)
GFFKR motif 1040..1044 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 130 1.000 Domainoid score I5179
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20091
Inparanoid 1 1.050 385 1.000 Inparanoid score I2011
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46425
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001200
OrthoInspector 1 1.000 - - otm43629
orthoMCL 1 0.900 - - OOG6_102503
Panther 1 1.100 - - O PTHR23220
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2587
SonicParanoid 1 1.000 - - X929
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.860

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