DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itga5

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_034707.5	Gene:	Itga5 / 16402	MGIID:	96604	Length:	1053	Species:	Mus musculus

Alignment Length:	1179	Identity:	310/1179 - (26%)
Similarity:	487/1179 - (41%)	Gaps:	242/1179 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RLRQNLGILIIL-QCVLTCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGA 77
            ||...|.:|::| ...|....|||:...|.|..|.|.|.||:||..:..|. :|.:    |||||
Mouse    24 RLPPLLPLLLLLWPPPLQVGGFNLDAEAPAVLSGPPGSLFGFSVEFYRPGR-DGVS----VLVGA 83

  Fly    78 PLDQNRQPNTTHSGALWRCPMTQRFDDCEQVITD--GRRNFDSEILSPPGND--EIKEDQWMGVT 138
            |.....||.....||::.||.......|..:..|  |.|..:|.:.|..|.:  |.|..||.|.|
Mouse    84 PKANTSQPGVLQGGAVYVCPWGTSPIQCTTIQFDSKGSRILESSLYSAKGEEPVEYKSLQWFGAT 148

  Fly   139 VRSNPLQANGSGGKVIVCAHRYMYIVRENRYGQ--GLCYLLTNDLQFEEVHEPCKGRPVQRQHED 201
            ||::       |..::.||..|.:...::....  |.|||.|.:......:.||:        .|
Mouse   149 VRAH-------GSSILACAPLYSWRTEKDPQNDPVGTCYLSTENFTRILEYAPCR--------SD 198

  Fly   202 Y------GLCQAGTSAALLDDDTMVLGSPGPYTWRGSI----------------WVTQVGGEYLQ 244
            :      |.||.|.||.......:|||.||.|.|:|.|                .:..|.|:...
Mouse   199 FGSAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQISESYYPEYLINPVQGQLQT 263

  Fly   245 RDKTTYYSDHSDLNSPVDKYSYLGMSVTGGRFFGH--MSYAAGAPRSE-GHGQVVIFDKSTDNPI 306
            |..::.|.|           ||||.||..|.|.|.  ..:.||.|:.. .:|.|.:.:.|
Mouse   264 RQASSVYDD-----------SYLGYSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTVLNGS----- 312

  Fly   307 PVHSI--LDGEQFGSSFGYELATADINGDHRPDLIVAAPLYFTKT------EGGAVYVYQNIQDT 363
            .:||:  :.|||..|.|||.:|..|.|||...||:|.|||...:|      |.|.||:|......
Mouse   313 DIHSLYNVSGEQMASYFGYAVAATDTNGDGLDDLLVGAPLLMERTADGRPQEVGRVYIYLQRPAG 377

  Fly   364 LPMKYTLKLTGPLE-SRFGLALANIGDLNKDNCEDLAVGAPYEG---NGVVYIYLGSSQGLNSKP 424
            :....||.|||..| ||||.:|..:|||::|...|:|:|||:.|   .|||:|:.|...||::||
Mouse   378 IDPTPTLTLTGQDEFSRFGSSLTPLGDLDQDGYNDVAIGAPFGGEAQQGVVFIFPGGPGGLSTKP 442

  Fly   425 AQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSV 489
            :|.:|.....|..|:     .||.::.|..|||.|.|||:::|:|....|::...|||||...|:
Mouse   443 SQVLQPLWAAGRTPD-----FFGSALRGGRDLDGNGYPDLIVGSFGVDKALVYRGRPIISASASL 502

  Fly   490 Q-RKELHNMDPNTPGCLDDPASNLTCFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKK---F 550
            . ...:.|.:..:.....:|.|   |.....|.:.......|.   :.:.||.: .|..|:   .
Mouse   503 TIFPSMFNPEERSCSLEGNPVS---CINLSFCLNASGKHVPNS---IGFEVELQ-LDWQKQKGGV 560

  Fly   551 SRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIK--ANTRDIQTPVRFRLKYSLVEPPLAD 613
            .|..|.   ..:...|::.:.:....|.:|:.:..|::  :..||..:|:...|.:||  .|.|.
Mouse   561 RRALFL---TSKQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSL--DPKAP 620

  Fly   614 SALVRLNPILD-QTQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETELEV 677
            .....|.|:|. |:::.::.:.....|||:|::|..:|.:.|      ....::..:.|:..|.:
Mouse   621 MDSHGLRPVLHYQSKSRIEDKAQILLDCGEDNICVPDLQLDV------YGEKKHVYLGDKNALNL 679

  Fly   678 RINVSNLAD-SAYEAQLFIAHQAGVSYVA-TKKPTN---ATCNSY---NTTLVACSLGNPMLRDT 734
            ..:..||.: .||||:|.:.......|.. .:.|.|   .:|:.:   .:..:.|.|||||...|
Mouse   680 TFHAQNLGEGGAYEAELRVTAPLEAEYSGLVRHPGNFSSLSCDYFAVNQSRQLVCDLGNPMKAGT 744

  Fly   735 TTFVTIRFQPKGLEPSEKIMLFHI------FANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAI 793
            :.:..:||....|:.::|.:.|..      ..|:.|.:|       ...::|..:|:::..|.:.
Mouse   745 SLWGGLRFTVPHLQDTKKTIQFDFQILSKNLNNSQSNVV-------SFPLSVEAQAQVSLNGVSK 802

  Fly   794 PEQSFYSGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSL 858
            ||       :|...|::....|    .|...:|:|..|||::.:.|:|||:..:..:.:..|.:|
Mouse   803 PE-------AVIFPVSDWNPQD----QPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQAL 856

  Fly   859 YSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQS 923
            ..        |.|||:.:|..:.                |..|.      |......:.:.|..|
Mouse   857 EG--------QQLLYVTKVTGLS----------------NCTSN------YTPNSQGLELDPETS 891

  Fly   924 RHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQD 988
            .|...|                             |.:              |..|:.|:|.:
Mouse   892 PHHLQK-----------------------------REA--------------PGRSSTASGTQ-- 911

  Fly   989 IVELDCNKGATNCVRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPES 1053
              .|.|.:  ..|.|:.|:...:.......:.:..|:|..|.:.        |.:...:.|....
Mouse   912 --VLKCPE--AKCFRLRCEFGPLHRQESRSLQLHFRVWAKTFLQ--------REYQPFSLQCEAV 964

  Fly  1054 YGVEVMDHNNIEVETRAYPELRNQ----------QRDTSIPWLIIILGIVGGLLLLALVTYVLWK 1108
            |....|.:   ::..|..|:.:.|          :....:|..||||.|:.|||||.|:.|||:|
Mouse   965 YEALKMPY---QILPRQLPQKKLQVATAVQWTKAEGSNGVPLWIIILAILFGLLLLGLLIYVLYK 1026

  Fly  1109 VGFFKRIRP 1117
            :|||||..|
Mouse  1027 LGFFKRSLP 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	21/62 (34%)
		Int_alpha	317..368	CDD:214549	21/56 (38%)
		Int_alpha	378..428	CDD:214549	25/52 (48%)
		Int_alpha	446..491	CDD:214549	19/45 (42%)
		Integrin_alpha2	479..1006	CDD:285619	110/547 (20%)
Itga5	NP_034707.5	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	46..111		25/69 (36%)
		Int_alpha	59..117	CDD:214549	21/62 (34%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	131..191		18/66 (27%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	196..248		16/59 (27%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	262..314		18/67 (27%)
		Int_alpha	271..>313	CDD:214549	16/57 (28%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	315..380		26/64 (41%)
		Int_alpha	325..382	CDD:214549	21/56 (38%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	381..440		28/58 (48%)
		Int_alpha	392..446	CDD:214549	25/53 (47%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	444..507		23/67 (34%)
		Int_alpha	458..510	CDD:214549	19/51 (37%)
		Integrin_alpha2	493..925	CDD:285619	110/546 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..910		8/73 (11%)
		GFFKR motif	1024..1028		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11158
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820