DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itga2

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_032422.2	Gene:	Itga2 / 16398	MGIID:	96600	Length:	1178	Species:	Mus musculus

Alignment Length:	1347	Identity:	294/1347 - (21%)
Similarity:	468/1347 - (34%)	Gaps:	451/1347 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LGILIILQCVLTCYNFNLEQRLPIVK-YGHPHS-HFGYSVATHTIGEANGPNKTNCVLVGAP--- 78
            |.:|:::|.:|.|..:|:  .||..| :..|.| .|||||...|..:.      |.:|||:|
Mouse    12 LRLLMLVQGILNCLAYNV--GLPGAKIFSGPSSEQFGYSVQQLTNPQG------NWLLVGSPWSG 68

  Fly    79 LDQNRQPNTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNP 143
            ..:||.      |.:::||:......||::......:..:.       .|||.:..:|:|:..||
Mouse    69 FPENRM------GDVYKCPVDLPTATCEKLNLQNSASISNV-------TEIKTNMSLGLTLTRNP 120

  Fly   144 LQANGSGGKVIVCAHRYMYIVRENRYGQGLCYLLTNDLQF------------------------- 183
                |:|| .:.|...:.:......|..|:|..::.|.||
Mouse   121 ----GTGG-FLTCGPLWAHQCGNQYYATGICSDVSPDFQFLTSFSPAVQACPSLVDVVVVCDESN 180

  Fly   184 -------------------------------EEVHEP---------------------------- 189
                                           :..:||
Mouse   181 SIYPWEAVKNFLVKFVTGLDIGPKKTQVALIQYANEPRIIFNLNDFETKEDMVQATSETRQHGGD 245

  Fly   190 -------------------CKGRP-----------------------VQRQHED----YGLCQAG 208
                               ..|||                       :|:.::|    :|:...|
Mouse   246 LTNTFRAIEFARDYAYSQTSGGRPGATKVMVVVTDGESHDGSKLKTVIQQCNDDEILRFGIAVLG 310

  Fly   209 --------------------------------TSAALLD-------------------------- 215
                                            ..||||:
Mouse   311 YLNRNALDTKNLIKEIKAIASTPTERYFFNVADEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEM 375

  Fly   216 ------------DDTMVLGSPGPYTWRGS----------IWVTQVGGEYLQRDKTTYYSDHSDLN 258
                        :|.::||:.|.:.|.|:          |:..|...:.|| |:     :||
Mouse   376 AQVGFSADYAPQNDILMLGAVGAFDWSGTLVQETSHKPVIFPKQAFDQVLQ-DR-----NHS--- 431

  Fly   259 SPVDKYSYLGMSVTGGRFFGHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGY 323
                  |:||.||........:.:.|||||:...||:|::..:....:.|.....|:|.||.||.
Mouse   432 ------SFLGYSVAAISTEDGVHFVAGAPRANYTGQIVLYSVNKQGNVTVIQSHRGDQIGSYFGS 490

  Fly   324 ELATADINGDHRPD-LIVAAPLYFT--KTEGGAVYVYQNIQDTLPMKYTLKLTGPL---ESRFGL 382
            .|.:.|::.|...| |:|.||.|..  |.|.|.||::...:..|.....|:  ||.   .:|||.
Mouse   491 VLCSVDVDKDTITDVLLVGAPTYMNDLKKEEGKVYLFTITKGILNQHQFLE--GPEGTGNARFGS 553

  Fly   383 ALANIGDLNKDNCEDLAVGAPY--EGNGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNG---QP 442
            |:|.:.|:|.|...|:.||:|.  |.:|.||||.|....:.:|.:|||..|       ||   :.
Mouse   554 AIAALSDINMDGFNDVIVGSPVENENSGAVYIYNGHQGTIRTKYSQKILGS-------NGAFRRH 611

  Fly   443 IRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPNTPGCLDD 507
            ::.||.|:.|..||:.:|..||.|||...   ||.|....|:   .|..:.|...|..|  .|:.
Mouse   612 LQFFGRSLDGYGDLNGDSITDVSIGALGQ---VIQLWSQSIA---DVAIEALFTPDKIT--LLNK 668

  Fly   508 PASNLTCFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKKF-SRVFFFDRENKRTNVLSRVVR 571
            .|.......|||  ...|..: |.::.:.:::..:...|..:. ||..|  |||....:...:|
Mouse   669 DAKITLKLCFRA--EFRPAGQ-NNQVAILFNMTLDADGHSSRVTSRGVF--RENSERFLQKNMV- 727

  Fly   572 VHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSALVRLNPILDQTQAHVD-FEGT 635
              .|...:|......|: ...|:..|:..|:..||..|        ..:|.|:.....|. |...
Mouse   728 --VNEVQKCSEHHISIQ-KPSDVVNPLDLRVDISLENP--------GTSPALEAYSETVKVFSIP 781

  Fly   636 FQKDCGDDDLCESNLIIRVE--PNITESSGNEYTLILDETELEVRINVSNLADSAYEAQLFIAHQ 698
            |.|:||.|.:|.|:||:.|:  |.|...|   :.:......|...:.:.|..:|||...:.....
Mouse   782 FYKECGSDGICISDLILDVQQLPAIQTQS---FIVSNQNKRLTFSVILKNRGESAYNTVVLAEFS 843

  Fly   699 AGVSYVATKKP---TNATCN-SYNTTLVACSLGNPMLR---DTTTFVTIRFQPKGLEPSEKIMLF 756
            ..:.:.:...|   |..||. ..:...|.|.:|.|.|:   ..|..:...|..:.|: ::..:.|
Mouse   844 ENLFFASFSMPVDGTEVTCEVGSSQKSVTCDVGYPALKSEQQVTFTINFDFNLQNLQ-NQAAINF 907

  Fly   757 HIFA-----NTTSKLVGPERP-ERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATD 815
            ..|:     |.....|....| ..|..:::.|...:|          ||..||..|  |.:....
Mouse   908 QAFSESQETNKADNSVSLTIPLLYDAELHLTRSTNIN----------FYEISSDEN--APSVIKS 960

  Fly   816 IEGHGPMGMDDVGSQVHHMFTI-FNEGPSTAPKVQMVIHWP-YSLYSDPQSGRPVQYLLYLEQVP 878
            :|..||          ..:|:: ...|.:......:.||.| |:...:|        ||||..:.
Mouse   961 VEDIGP----------KFIFSLKVTAGSAPVSMALVTIHIPQYTKEKNP--------LLYLTGIQ 1007

  Fly   879 TVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSF-NKSLIHSQRSYYSSS 942
            |.:.....|...   :|||.|..         :||:.          || |::..|::
Mouse  1008 TDQAGDISCTAE---INPLKLPH---------TAPSV----------SFKNENFRHTK------- 1043

  Fly   943 HRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECD 1007
                                                            ||||.  .|:|..|.|.
Mouse  1044 ------------------------------------------------ELDCR--TTSCSNITCW 1058

  Fly  1008 ILNMPALSEAQVVVKARLWNSTL-VSEYPRVERVRIFSTATAQI----PESYGVEVMDHNNIEVE 1067
            :.::...:|..:.|..|:||.|. .|.:..|:     .||.|:|    |:.:   |::.|.:.:.
Mouse  1059 LKDLHMKAEYFINVTTRVWNRTFAASTFQTVQ-----LTAAAEIDTHNPQLF---VIEENAVTIP 1115

  Fly  1068 TRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKR 1114
            ..    :........:|..:||..|:.|:|||..:|..|||:|||||
Mouse  1116 LM----IMKPTEKAEVPTGVIIGSIIAGILLLLAMTAGLWKLGFFKR 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	20/66 (30%)
		Int_alpha	317..368	CDD:214549	19/53 (36%)
		Int_alpha	378..428	CDD:214549	21/51 (41%)
		Int_alpha	446..491	CDD:214549	17/44 (39%)
		Integrin_alpha2	479..1006	CDD:285619	110/546 (20%)
Itga2	NP_032422.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	31..89		21/69 (30%)
		Int_alpha	44..92	CDD:214549	18/59 (31%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	98..158		17/71 (24%)
		vWA_integrins_alpha_subunit	170..350	CDD:238746	13/179 (7%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	363..417		7/53 (13%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	420..472		18/66 (27%)
		Int_alpha	430..473	CDD:214549	15/51 (29%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	474..536		22/61 (36%)
		Cell attachment site. /evidence=ECO:0000255	480..482		0/1 (0%)
		Int_alpha	484..532	CDD:214549	18/47 (38%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	537..595		22/59 (37%)
		Int_alpha	548..601	CDD:214549	21/52 (40%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	601..661		22/72 (31%)
		Int_alpha	611..>637	CDD:214549	10/25 (40%)
		Integrin_alpha2	646..1057	CDD:285619	110/545 (20%)
		Integrin_alpha	1152..1166	CDD:278771	6/7 (86%)
		GFFKR motif	1154..1158		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810