DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itga1

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001028400.2	Gene:	Itga1 / 109700	MGIID:	96599	Length:	1179	Species:	Mus musculus

Alignment Length:	1388	Identity:	316/1388 - (22%)
Similarity:	488/1388 - (35%)	Gaps:	482/1388 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RPNCRLRQNLGILIILQCVL-TCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCV 73
            || ..|...:..:.:|..:| .|.:||::.:..:...|.....|||:|..:...|.      ..|
Mouse     5 RP-ASLEVTVACIWLLTVILGVCISFNVDVKNSMSFSGPVEDMFGYTVQQYENEEG------KWV 62

  Fly    74 LVGAPLDQNRQPNTTHSGALWRCPM-TQRFDDCEQVITDGRRNFDSEI-LSPPGNDEIKEDQWMG 136
            |:|:||  ..||. ..:|.:::||: .:|...|.::        |..: .|.|...||||:...|
Mouse    63 LIGSPL--VGQPK-ARTGDVYKCPVGRERSMPCVKL--------DLPVNTSIPNVTEIKENMTFG 116

  Fly   137 VTVRSNPLQANGSGGKVIVCAHRYMYIVRENRYGQGLC--------------------------- 174
            .|:.:||     .|| .:.|...|.|......|..|:|
Mouse   117 STLVTNP-----KGG-FLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSFAPVQECSTQLDIVI 175

  Fly   175 --------------YLLTNDL-------------------------------------------- 181
                          ....|||
Mouse   176 VLDGSNSIYPWESVTAFLNDLLKRMDIGPKQTQVGIVQYGANVTHEFNLNKYSSTEEVLVAANKI 240

  Fly   182 ------------------------------------------------QFEEVHEPCKGRPVQR- 197
                                                            :.::|.:.|:...:||
Mouse   241 GRRGGLQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNYRLKQVIQDCEDENIQRF 305

  Fly   198 -----QHEDYG------------------------------------------------------ 203
                 .|.:.|
Mouse   306 SIAILGHYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKALGERIFALEATADQSA 370

  Fly   204 ------LCQAGTSAALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSDLNSPVD 262
                  :.|.|.||. ...|.::||:.|.|.|.|:: |.|...:.:....||:.::.:.:|.|:
Mouse   371 ASFEMEMSQTGFSAH-YSQDWVMLGAVGAYDWNGTV-VMQKANQIVIPHNTTFQTEPTKMNEPL- 432

  Fly   263 KYSYLGMSVTGGRFFGHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELAT 327
             .||||.:|......|.:.|.||.||....|||||: |..|..:.:...|.|||.||.||..|.|
Mouse   433 -ASYLGYTVNSATIPGDVLYIAGQPRYNHTGQVVIY-KMEDGDVNILQTLSGEQIGSYFGSVLTT 495

  Fly   328 ADINGDHRPD-LIVAAPLYF--TKTEGGAVYVYQNIQDTL-------PMKYT----LK------- 371
            .||:.|...| |:|.||:|.  .|.|.|.||||...|...       |:|.|    ||
Mouse   496 IDIDKDSYTDLLLVGAPMYMGTEKEEQGKVYVYAVNQTRFEYQMSLEPIKQTCCSSLKDNSCTKE 560

  Fly   372 -LTGPLESRFGLALANIGDLNKDNCEDLAVGAPYEGN--GVVYIYLGSSQGLNSKPAQKIQASEL 433
             ...|..:|||.|:|.:.|||.|...|:.:|||.|.:  |.||||.||.:.:..:.||:|.:
Mouse   561 NKNEPCGARFGTAVAAVKDLNVDGFNDVVIGAPLEDDHAGAVYIYHGSGKTIRKEYAQRIPS--- 622

  Fly   434 GGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMD 498
            ||   :|:.::.||.||.|..||:.:...||.||....:|  :..||.:..::.::      |.:
Mouse   623 GG---DGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAA--LFWARDVAVVKVTM------NFE 676

  Fly   499 PN-----TPGCLDDPASNLTCFTFRACCSIEPYDEKNK--ELRLAYSVEAETFDHLKKFSRVFFF 556
            ||     ...|..: .....|.....|..::...:::.  |..|.|.|   |.|.|::.||.||.
Mouse   677 PNKVNIQKKNCRVE-GKETVCINATMCFHVKLKSKEDSVYEADLQYRV---TLDSLRQISRSFFS 737

  Fly   557 DRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEP---PLADSALVR 618
            ..:.:      |:.|..|...:||...:.|: .:..|.|..||..|.::|.:|   |:.|.||.
Mouse   738 GTQER------RIQRNLTVRESECIRHSFYM-LDKHDFQDSVRVTLDFNLTDPENGPVLDDALP- 794

  Fly   619 LNPILDQTQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLIL---DETELEVRIN 680
                 :....|:    .|.||||:.:.|.|:|.:.|       |..|..|::   ...:..|.:.
Mouse   795 -----NSVHGHI----PFAKDCGNKERCVSDLTLDV-------STTEKNLLIVRSQNDKFNVSLT 843

  Fly   681 VSNLADSAYEAQLFIAHQAGVSYVATKKPTNATCNSYNTTLVACSLGNPMLR--DTTTFVTIRFQ 743
            |.|..||||..:..:.:...:.:...::....:|.|...  :.|.:|.|.||  |...|..| ||
Mouse   844 VKNKGDSAYNTRTVVQYSPNLIFSGIEEIQKDSCESNQN--ITCRVGYPFLRTGDVVNFKII-FQ 905

  Fly   744 PKGLEPSEKIMLFHIFANTTSKLVGPERPERDL---RVNVVRRAKLNFRGWAIPEQ-----SFYS 800
            ......||..:: |:.|.:.|     |.|...|   .||:           :||.:     .|||
Mouse   906 FNTSHLSENAII-HLSATSDS-----EEPLESLYDNEVNI-----------SIPVKYEVGLQFYS 953

  Fly   801 GSSV--ANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQ 863
            .:|.  .:..||....::..    ...|:|.:::..:||...|....|::::.|.:| :|.||
Mouse   954 SASEHHISVAANETVPELIN----STKDIGDEINVFYTIRKRGHFPMPELRLAISFP-NLTSD-- 1011

  Fly   864 SGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFN 928
             |.||.|       ||
Mouse  1012 -GYPVLY-------PT------------------------------------------------- 1019

  Fly   929 KSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELD 993
                     .:|||                     :.|....|.:.||...|  :|||..|.:.:
Mouse  1020 ---------GWSSS---------------------DNVNCRPRSLEDPLGIN--SGKKMTISKSE 1052

  Fly   994 CNKGAT--NC-----VRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIP 1051
            ..|..|  :|     ..|.|.:|  |: ..:||.|...||..|.:..:        ||:....|
Mouse  1053 VLKRGTIQDCSTCKIATITCHLL--PS-DVSQVNVSLILWKPTFIKAH--------FSSLNLTI- 1105

  Fly  1052 ESYGVEVMDHNNIEVETRAYPELRNQQRDTSI-----------PWLIIILGIVGGLLLLALVTYV 1105
              .|....:::::.:.:      .|::|:.:|           |..:|:|....|||||.|:...
Mouse  1106 --RGELQSENSSLTLSS------SNRKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILA 1162

  Fly  1106 LWKVGFFKRIRPTDPTLSGNLEK 1128
            |||:|||||      .|...:||
Mouse  1163 LWKIGFFKR------PLKKKMEK 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	17/63 (27%)
		Int_alpha	317..368	CDD:214549	24/60 (40%)
		Int_alpha	378..428	CDD:214549	23/51 (45%)
		Int_alpha	446..491	CDD:214549	14/44 (32%)
		Integrin_alpha2	479..1006	CDD:285619	119/558 (21%)
Itga1	NP_001028400.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	30..91		18/69 (26%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	101..160		18/64 (28%)
		vWA_integrins_alpha_subunit	171..351	CDD:238746	9/179 (5%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	365..417		13/53 (25%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	422..474		20/54 (37%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	475..537		27/61 (44%)
		Int_alpha	485..>528	CDD:214549	20/42 (48%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	556..614		22/57 (39%)
		Int_alpha	567..620	CDD:214549	23/52 (44%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	618..678		20/73 (27%)
		Integrin_alpha2	663..1045	CDD:285619	112/531 (21%)
		GFFKR motif	1167..1171		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832090
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740