DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itga9

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_598482.2	Gene:	Itga9 / 104099	MGIID:	104756	Length:	1036	Species:	Mus musculus

Alignment Length:	1196	Identity:	320/1196 - (26%)
Similarity:	521/1196 - (43%)	Gaps:	258/1196 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNRQPNTTHS-GALWRCP 97
            :||:.:.|:...|...|.|||:|..|.      .:.|..||||||...::...:..| ||:::|.
Mouse    31 YNLDAQRPVRFQGPSGSFFGYAVLEHF------HDNTRWVLVGAPKADSKYSTSVKSPGAVFKCR 89

  Fly    98 MTQRFD-DCEQV-ITDGRRNFDSEILSPPG----NDEIKEDQWMGVTVRSNPLQANGSGGKVIVC 156
            :....| .|.:: :..||...     :|.|    .|  ::|:||||::...|    .:.|:|:.|
Mouse    90 VHTNPDRRCTELDMARGRTRG-----APCGKTCRGD--RDDEWMGVSLARQP----RADGRVLAC 143

  Fly   157 AHRY--MYIVRENRYGQGLCYLLTNDLQFE-EVHEPCKGRPVQRQHEDYGLCQAGTSAALLDDDT 218
            |||:  :|...::....|.|||:.::||.: :|..||.....::..|::|.||||. |....::.
Mouse   144 AHRWKNIYYEADHILPHGFCYLIPSNLQAKGKVLIPCYEEYKKKYGEEHGSCQAGI-AGFFTEEL 207

  Fly   219 MVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYY--SDHSDLNSPVDKYSYLGMSVTGGRFFGHMS 281
            :|:|:||.:.|.|::.|       |.....||:  :|.:.:|.   :|:|||.:||.|. |.|.|
Mouse   208 VVMGAPGSFYWAGTLKV-------LNLTDNTYFKLNDEAIMNR---RYTYLGYAVTAGH-FSHPS 261

  Fly   282 ---YAAGAPRSEGHGQVVIF--DKSTDNPIPVHSILDGEQFGSSFGYELATADINGDHRPDLIVA 341
               ...|||:.||.|:|.||  |:.:...|.:.. ..|::.||.||..|...|:|.|...||:|.
Mouse   262 ITDVVGGAPQDEGIGKVYIFRADRRSGTLIKIFQ-ASGKKMGSYFGSSLCAVDLNMDGLSDLLVG 325

  Fly   342 APLYFTKTEGGAVYVYQNIQDTLPMKYTLKLTG--PLESRFGLALANIGDLNKDNCEDLAVGAPY 404
            ||::....:.|.|.||.| |....::..|.|||  ...:.||.::||:||::.|...|:|||||.
Mouse   326 APMFSEIRDEGQVTVYLN-QGHGALEEQLTLTGDAAYNAHFGESIANLGDIDDDGFPDVAVGAPK 389

  Fly   405 EGN--GVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIG 467
            |.:  |.||||.|.:.|:..|.:.|:....|..|      :|.||.||||..|:|.|.||||.||
Mouse   390 EEDFAGAVYIYHGDANGIVPKYSMKLSGRRLNPT------LRMFGQSISGGIDMDGNGYPDVTIG 448

  Fly   468 AFNSSAAVILLARPIISIQTSVQRKELHNMDPNTPGCLD--DPAS--NLT-CFTFRACCSIEPYD 527
            ||.|.:.|:|.|||:|::..|:......|:  ..|.|.|  .|.:  |:| ||.|..
Mouse   449 AFLSDSVVLLRARPVITVDVSIFLPGSINI--TAPQCHDGQQPVNCLNVTVCFRFHG-------- 503

  Fly   528 EKN--KELRLAYSVEAETFDHLK-KFSRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKA 589
             ||  .|:.|.|::.|:.....| :..||:|.........|..|:...|.:  ..|.....::|.
Mouse   504 -KNVPGEIGLNYNLTADVAQKEKGQLPRVYFVLFGETAGQVSERLQLSHMD--EVCHHYVAHVKR 565

  Fly   590 NTRDIQTPVRFRLKYSLVEPPLA--DSALVRLNPIL-----------DQTQAHVDFEGTFQKDCG 641
            ..:|:.:|:.|...|||.|..:.  |..|..|.|:|           :||        .|:::|.
Mouse   566 RVQDVISPIVFEAAYSLDEHVMGEEDRELPDLTPVLRWKKGQRISQKNQT--------VFERNCQ 622

  Fly   642 DDDLCESNLIIRVEPNITESSGNEYT--LILDETE-LEVRINVSNLADSAYEA--------QLFI 695
            .:| |.::|.:|  ..:..||.:|.|  |.|...: :.:.|::|||.|.||:|        :||.
Mouse   623 SED-CAADLQLR--GKLLLSSVDEKTPHLALGAVKNISLNISISNLGDDAYDANVSFNVSRELFF 684

  Fly   696 AHQAGVSYVATKKPTNATCNSYNTTLVACSLGNPMLRDTTTF-VTIRFQPKGLEPSEKIMLFHIF 759
            .:      :..|:....:|....:..:.||:|.|.:|..:.: .::.|....|...|:|:.|.:.
Mouse   685 IN------MWQKEEMGISCELLESDFLKCSVGFPFMRSKSKYEFSVIFDTSHLSGEEEILSFIVT 743

  Fly   760 ANTTSKLVGPERPER------DLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEG 818
            |.:.:.    ||.|.      .|.|.:|.....:..|...| .||..|.||      .|:..|:
Mouse   744 AQSGNL----ERSEALHDNTLTLTVPLVHEVDTSITGIVSP-TSFVYGESV------DASNFIQ- 796

  Fly   819 HGPMGMDDVGSQVHHM-----FTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVP 878
                 :||  .:.|..     ..::|.||||.|...:.|.:|..|  .|....       :.||.
Mouse   797 -----LDD--QECHFQPVNITLQVYNMGPSTLPGSSVSISFPSRL--SPGGAE-------MFQVQ 845

  Fly   879 TVEVSQ--GECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSS 941
            .:.|||  |.|.:              :.||.....|.:            .:::.|:..:::|.
Mouse   846 DMVVSQEKGNCSL--------------QRNPTPCIIPQE------------QENIFHTIFAFFSK 884

  Fly   942 SHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIEC 1006
            |                                         |:|    .|||.|..:.|:.:.|
Mouse   885 S-----------------------------------------GRK----VLDCEKPGSFCLTLHC 904

  Fly  1007 DILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAY 1071
            ::..:|. .|::.:....|.|:.::.: .....::..:.|..::..:..|..:.:.|.|.....:
Mouse   905 NLSALPK-EESRTINLYMLLNTEILKK-DSSSVIQFMARAKVKVEPALRVVEIANGNPEETLVVF 967

  Fly  1072 PELRN-QQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGNLEKMNEEKPF 1135
            ..|.| :.|...:.| ||.:.::.|:|:..|:..:|||:|||:|                ..|..
Mouse   968 EALHNLEPRGYVVGW-IIAISLLVGILIFLLLAVLLWKMGFFRR----------------RYKEI 1015

  Fly  1136 LAPSKNTHHVFXQEGTVGWDLVRRRR 1161
            :...||      :|...|||.|::.:
Mouse  1016 IEAEKN-----RKENEDGWDWVQKNQ 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	19/65 (29%)
		Int_alpha	317..368	CDD:214549	19/50 (38%)
		Int_alpha	378..428	CDD:214549	22/51 (43%)
		Int_alpha	446..491	CDD:214549	25/44 (57%)
		Integrin_alpha2	479..1006	CDD:285619	127/572 (22%)
Itga9	NP_598482.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	36..97		20/66 (30%)
		Int_alpha	45..102	CDD:214549	19/62 (31%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	109..175		22/76 (29%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	183..233		16/57 (28%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	234..290		22/59 (37%)
		Int_alpha	245..295	CDD:214549	21/50 (42%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	291..350		21/60 (35%)
		Int_alpha	301..348	CDD:214549	19/47 (40%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	352..409		25/56 (45%)
		Int_alpha	362..415	CDD:214549	22/52 (42%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	412..475		29/68 (43%)
		Int_alpha	426..>467	CDD:214549	24/40 (60%)
		Integrin_alpha2	460..904	CDD:285619	127/572 (22%)
		GFFKR motif. /evidence=ECO:0000250\|UniProtKB:Q13797	1006..1010		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810