Protein Alignment mew and itgae.2

DIOPT Version :9

• Sequence 1: NP_001285196.1
• Gene: mew / 32275
• FlyBaseID: FBgn0004456
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: XP_003200076.2
• Gene: itgae.2 / 100536705
• ZFINID: ZDB-GENE-130530-671
• Length: 1098
• Species: Danio rerio
• Alignment Length: 1159
• Identity: 262/1159 - (22%)
• Similarity: 415/1159 - (35%)
• Gaps: 345/1159 - (29%)

  Fly    30 TCYNFNLEQRLPIVKYGHPHSHFGYSVATH--TIGEANGPNKTNCVLVGAPLDQNRQPNTTHSGA 92
            ||::.|    ..||:||.       |:.|.  .:...:|...         |.:.:|....::
Zfish   214 TCFDCN----FAIVQYGS-------SIRTELSLLDNEDGARS---------LQKVKQIKQIYN-- 256

  Fly    93 LWRCPMTQRFDDCEQVITD------GRRN---------FDSEILSPPGN-DEI-KEDQWMGVTVR 140
                 :|:.......|:||      |.:|         .|.:||..|.. ||: .:.|..|||..
Zfish   257 -----LTKTASAINHVLTDIFIPENGSKNNSEKIIIVLSDGKILGDPMTLDEVLNKTQMKGVTRY 316

  Fly   141 SNPLQANGSGGKVIV---CAHRYMYIVRENRYGQGLCYLLTNDLQFEEVHEPCKGRPVQRQHEDY 202
            |     .|.|..::.   .......|....:|.....|...||: ...:.....|....:.....
Zfish   317 S-----IGVGDGILKNKDAIKEMTQIADPGKYYSVSSYGALNDI-LSSLERGIIGTEGTQHGFKL 375

  Fly   203 GLCQAGTSAALLDDDTMV---LGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSDLNSPVDKY 264
            .|.:||.|:.||.::..|   .|:.|.|.|.        ||.:|:...|..:.:.|...:   |:
Zfish   376 QLAEAGFSSHLLYNEQKVEALFGAVGAYDWS--------GGVFLKSGNTVKFLNDSHNET---KF 429

  Fly   265 SYLGMSVTGGRFFGHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELATAD 329
            .|||.|||.........|.:||||....|.|.|||...      ..:|.|:|.||.||..|...|
Zfish   430 GYLGYSVTSAHLPSKTLYISGAPRYNLTGAVFIFDGLE------KYVLHGDQVGSYFGSVLCALD 488

  Fly   330 INGD-HRPDLIVAAPLYFTKTEGGAVYVYQNIQDTLPMKYTLKL---TGPLESRFGLALANIGDL 390
            ||.| |...|:|.||.:....|.|.|.||:..|:....:..::|   .|...:|||.|:.:|||:
Zfish   489 INKDEHTDHLLVGAPHFHLNGEEGKVLVYKLNQEDRFERAPVELRGDAGQTFARFGAAIGSIGDI 553

  Fly   391 NKDNCEDLAVGAPYE--GNGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISIS-G 452
            :.:...|:|||||.|  ..|.||||.|..:||  :.:|||..|:.      |..:..||.|:| |
Zfish   554 DNNKFNDVAVGAPLETGSAGSVYIYSGFEEGL--RFSQKISPSDF------GMKLVYFGQSVSVG 610

  Fly   453 NTDLDDNSYPDVVIGAFNSSAAV----ILLARPIISIQTSVQRKELHNMDPNTPGCLDDPASNLT 513
            .....|  .|.:.:|:....:..    :|:..|.|.|.|.|... .|.|         :..|:..
Zfish   611 PAPASD--IPCIAVGSLGRVSVFETIPVLIIEPTIKIDTEVIAL-THQM---------NKISSEL 663

  Fly   514 CFTFRACCSIEP---YDEKNKELRLAYSVEAET----------FDHLKKFSRVFFFDRE--NKRT 563
            ......|.:|:.   ..||::...:.|.::.::          .|.|.|.:.....|.|  ||:.
Zfish   664 SMKITVCFNIKKGKLKAEKSETQAVDYEIDLDSGASKKRLTCGADSLIKDTFTLTPDEECTNKKL 728

  Fly   564 NVLSRVVRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLV----EPPLADSALVRLNPILD 624
            ..|         |..:|              .:|::.:|.:||.    |.|:.         |||
Zfish   729 TYL---------GCFDC--------------FSPIKIKLSFSLASNKNEAPIR---------ILD 761

  Fly   625 Q-TQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNIT--ESSGNEYTLILDETE-LEVRINVSNLA 685
            . |...|..|..|:|||...| |        :|:||  :|..:|.|:.:.||: |.:..|.:|..
Zfish   762 AFTPTEVVKEIPFEKDCQAAD-C--------KPSITLSDSKISETTITMGETQNLNINFNFTNTG 817

  Fly   686 DSAYEAQLFIAHQAGVSYVATKKPTNATCNSYNTTLVACSLGNPML---RDTTTFVTIRFQPKG- 746
            |.:|:..|.:.:.   |.::.:|...|.|...|...:.|.|.:|:.   ..|..|::.:...|.
Zfish   818 DPSYKTTLTLTYP---SILSERKIEGAACPVKNDNQIQCHLQHPVFTRSAQTNLFISWQLNDKSD 879

  Fly   747 LEPSEKIMLFHIFANTTSKLVGPERPERDLRV---NVVRRAKLNFRGWAIPEQSFYSGSSVANSV 808
            |:.||      |.||.||:..|.:.  .|.|:   ||:....:..||.|.|
Zfish   880 LKKSE------IIANLTSQNNGIQL--LDSRIYTFNVMYFLPILIRGSAEP-------------- 922

  Fly   809 ANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLY 873
             |....:..|.|                      .|.|     |.:......:.:.|..:..::.
Zfish   923 -NILRIEEGGKG----------------------KTQP-----IKFKIQFQGENKYGATIDVIIT 959

  Fly   874 LEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSY 938
            ::    ::.|:.:.|:.|  :.|         ....|.|
Zfish   960 IK----MDTSKTDLHITK--IQP---------EVCVLEA-------------------------- 983

  Fly   939 YSSSHRDDHSDDTQSNRNRVRR-SFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCV 1002
                             |:|:. |::.:.|.                |:..|:.::.|
Zfish   984 -----------------NKVKEASYIYKCTL----------------KELQIITIEAN------- 1008

  Fly  1003 RIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVE 1067
               ..|.::...||..:|.....::.||   |...:.::.|   |.::|.:         .::|.
Zfish  1009 ---VFIHDVQDTSEKIIVEGQYSYDETL---YSAKDTIKSF---TLEVPVT---------KMQVM 1055

  Fly  1068 TRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPT 1121
            |...|               ||.|.:||.|.|.:...:|.|.|||:|....|.|
Zfish  1056 TSKGP---------------IIGGSIGGFLFLLIFIIILIKCGFFRRRHKVDQT 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	7/64 (11%)
		Int_alpha	317..368	CDD:214549	20/51 (39%)
		Int_alpha	378..428	CDD:214549	23/51 (45%)
		Int_alpha	446..491	CDD:214549	14/49 (29%)
		Integrin_alpha2	479..1006	CDD:285619	103/557 (18%)
itgae.2	XP_003200076.2	vWFA	180..355	CDD:320736	35/172 (20%)
		Int_alpha	429..>465	CDD:214549	15/35 (43%)
		Int_alpha	477..>517	CDD:214549	17/39 (44%)
		Int_alpha	540..589	CDD:214549	22/50 (44%)
		Integrin_alpha2	635..>922	CDD:312071	83/348 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574903
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D743479at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850