Protein Alignment mew and itga9

DIOPT Version :10

• Sequence 1: NP_001285196.1
• Gene: mew / 32275
• FlyBaseID: FBgn0004456
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: XP_002940293.3
• Gene: itga9 / 100494771
• XenbaseID: XB-GENE-994231
• Length: 1034
• Species: Xenopus tropicalis
• Alignment Length: 1195
• Identity: 300/1195 - (25%)
• Similarity: 508/1195 - (42%)
• Gaps: 239/1195 - (20%)

  Fly    25 LQCVLTC-YNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNRQPNTT 88
            :...|.| ||.:|:.  |:|..|...|.|||||..|...|      |..||||||...:|..::.
 Frog    21 ISVTLVCSYNVDLDH--PVVFRGPNGSFFGYSVLEHYHDE------TRWVLVGAPKADSRYSSSI 77

  Fly    89 HS-GALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQANGSGGK 152
            .: ||:::|.:....:.....:..||.|............: :||:|||||:...| :||||
 Frog    78 KTPGAVFKCRVHSNPNKSCTELDLGRGNSRGTRCGKTCKGD-REDEWMGVTLARQP-KANGS--- 137

  Fly   153 VIVCAHRY--MYIVRENRYGQGLCYLLTNDLQFEEVHE------PCKGRPVQRQHEDYGLCQAGT 209
            |:.||||:  :|...|:....|.|.::..:|     |.      ||.....::..|::|.||||.
 Frog   138 VLACAHRWKNIYYESEDILPYGYCVIIPPNL-----HANGNNLMPCYEEYKKKYGEEHGSCQAGI 197

  Fly   210 SAALLDDDTMVLGSPGPYTWRGSIWVTQV-GGEYLQ-RDKTTYYSDHSDLNSPVDKYSYLGMSVT 272
            :.:.: ::.:|:|:||.|.|.|::.|..: ..:|.: ||:.          :...:|:|||.:||
 Frog   198 AGSFM-EELVVMGAPGSYYWTGTVKVLNLTDNKYFKLRDQV----------ATEKRYTYLGYAVT 251

  Fly   273 GGRFF--GHMSYAAGAPRSEGHGQVVIF--DKSTDNPIPVHSILDGEQFGSSFGYELATADINGD 333
            .|.|.  ..|...||||:....|:|.||  ||.:.:.:.:.. ..|::.||.||..|...|:|.|
 Frog   252 AGHFSQPTTMDVVAGAPQDSRIGKVFIFRTDKRSVSLVKIFQ-ASGKKVGSYFGSSLCAVDLNSD 315

  Fly   334 HRPDLIVAAPLYFTKTEGGAVYVYQNIQDTLPMKYTLKLTG--PLESRFGLALANIGDLNKDNCE 396
            ...||:|.||::....:.|.|.||.|..:.: |...:.|.|  ...:.||.::||:||::.|...
 Frog   316 GLSDLLVGAPMFSEVRDEGQVTVYINRGNGV-MDEHINLNGDNAYNAHFGESMANLGDIDDDGFP 379

  Fly   397 DLAVGAPYEGN--GVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISISGNTDLDDN 459
            |:|:|||.|.:  |.||||.|.:.|:.||.:.:|.:..:|   |.   :..||.|:||..|:|.|
 Frog   380 DVAIGAPQEDDYAGAVYIYHGDTLGIVSKYSMRISSKSIG---PG---LMMFGQSVSGGIDMDKN 438

  Fly   460 SYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPNTPGCLDDPAS----NLT-CFTFRA 519
            .|.|:.||||.|..||:|..||:|::..::......|:  ..|.|.|....    |:| ||.||.
 Frog   439 GYLDLTIGAFMSDTAVLLRTRPVITVDVTILLPTSINI--TAPQCHDGTQQINCVNVTVCFRFRG 501

  Fly   520 CCSIEPYDEKNKELRLAYSVEAETFDHLK-KFSRVFFFDRENKRTNVLSRVVRVHTNGRTECQAV 583
                   .....|:.|.|::.|:.....| :..|||..........|..::...|.  ..:|:..
 Frog   502 -------KHVPGEIELYYNLTADVAKKEKSQQPRVFLVSSGENVAQVSEKLQLTHL--ELKCEQY 557

  Fly   584 TGYIKANTRDIQTPVRFRLKYSLVEPPL--ADSALVRLNPIL-----------DQTQAHVDFEGT 635
            ..::|...:|:.:|:.|...|||.|..:  ....|..|.|||           :||:
 Frog   558 LAHVKRRVKDVISPIVFEASYSLGEHIINNQQKELPALKPILRWKKGDKLAQRNQTR-------- 614

  Fly   636 FQKDCGDDDLCESNLIIRVEPNITE-SSGNEYTLILDETELEVRINVSNLADSAYEAQLFIAHQA 699
            |:::|..|| |.::|.::.:..::. .|...|..:.....:.:.|:|||..|.||:..::.....
 Frog   615 FERNCRSDD-CAADLNLKGKLLLSSFDSKTPYLALGAVKNISLNISVSNYGDDAYDTNVYFNFSR 678

  Fly   700 GVSYVA--TKKPTNATCNSYNTTLVACSLGNPMLRDTTTF-VTIRFQPKGLEPSEKIMLFHIFAN 761
            .:.::.  .:.....:|.......:.||:|.|.:|..:.: .::.|....|...|:.:.|.:.|.
 Frog   679 ELYFIKMWQEDELGISCELLEDDFLKCSVGFPFMRSKSKYKFSVIFDTIHLSGDEESLQFLVTAQ 743

  Fly   762 TTSKLVGPERPERD----LRVNVVRRAKLNFRGWAIPEQSFYSGSSV--ANSVANTAATDIEGH- 819
            :.:  :..|....|    |.|:::.....:..|...| .||..|.||  :|.:   ...|:|.|
 Frog   744 SGN--IEKEESLHDNILHLAVSLMHEVDTSVTGVVSP-SSFVYGESVDPSNFI---QLQDLECHF 802

  Fly   820 GPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQ 884
            .|:...         |.::|.||||.|...:.:.:|..|.:....      :.|::.: .|...:
 Frog   803 QPLNFS---------FQVYNAGPSTLPGSTINVLFPNRLTATGAE------MFYIQDI-MVSQDK 851

  Fly   885 GECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSD 949
            |.|...|              |||....|..            .:::.|:..::::.|
 Frog   852 GNCSFQK--------------NPAPCVIPQD------------KENIFHTIFAFFTKS------- 883

  Fly   950 DTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNMPAL 1014
                                              |:|.    |:|.:.:.:|:.:.|.|.:: |.
 Frog   884 ----------------------------------GRKM----LECERTSKSCLVLNCYISSL-AK 909

  Fly  1015 SEAQVVVKARLWN-------STLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYP 1072
            .|.:.:....|.|       |:.|.::.....|::.||..|       :||...|:.:. |..:.
 Frog   910 EETRNIDVLMLLNTEILKKDSSSVIQFVSKAVVKVDSTLRA-------IEVQQGNSNQA-TVIFE 966

  Fly  1073 ELRN-QQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGNLEKMNEEKPFL 1136
            .|.| :.|...:.| ||.:.::.|:|:..|:..:|||:|||:|                ..|..:
 Frog   967 ALHNLEPRGYVVGW-IIAISLLVGILIFLLLAVLLWKMGFFRR----------------RYKEII 1014

  Fly  1137 APSKNTHHVFXQEGTVGWDLVRRRR 1161
            ...||      :|....|:.|::.:
 Frog  1015 EAEKN-----RKENEESWNWVQKNQ 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	19/63 (30%)
		Int_alpha	317..368	CDD:214549	19/50 (38%)
		Int_alpha	378..428	CDD:214549	22/51 (43%)
		Int_alpha	446..491	CDD:214549	21/44 (48%)
		Integrin_alpha2	480..1006	CDD:462478	106/555 (19%)
itga9	XP_002940293.3	Int_alpha	43..91	CDD:214549	19/53 (36%)
		Int_alpha	243..>280	CDD:214549	16/36 (44%)
		Int_alpha	300..345	CDD:214549	18/44 (41%)
		Int_alpha	360..413	CDD:214549	22/52 (42%)
		Int_alpha	424..>465	CDD:214549	21/40 (53%)
		Integrin_alpha2	459..902	CDD:462478	106/555 (19%)