Protein Alignment mew and itga3b

DIOPT Version :10

• Sequence 1: NP_001285196.1
• Gene: mew / 32275
• FlyBaseID: FBgn0004456
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: NP_001177238.1
• Gene: itga3b / 100331874
• ZFINID: ZDB-GENE-050411-55
• Length: 1041
• Species: Danio rerio
• Alignment Length: 1194
• Identity: 333/1194 - (27%)
• Similarity: 526/1194 - (44%)
• Gaps: 235/1194 - (19%)

  Fly    17 QNLGILIILQCVL-TCYNFNLEQRLPIVKYGHPH-SHFGYSVATHTIGEANGPNKTNCVLVGAPL 79
            ::|.:.:.:.|.: |...||::.:.|::|.|... |.||:|||.|...|   ..|.|.:|||||
Zfish     4 KSLHLCVFVICAIQTNTGFNIDVQFPVIKEGKTKGSLFGFSVALHKQTE---KAKKNLLLVGAP- 64

  Fly    80 DQNRQPNTT-----HSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTV 139
            .:..||..:     .:||::.||:|...|||..:          :::|||.:.::.|..|:||||
Zfish    65 QEKAQPQLSKFKINETGAVYYCPITVNLDDCGSM----------DLISPPKSTDMLEGMWLGVTV 119

  Fly   140 RSNPLQANGSGGKVIVCAHRY---MYIVRENRYGQGLCYLLTNDLQFE-------EVHEPCKGRP 194
            .|   |.|  ||:|:.|.|||   :....|.:...|.||:..|||.::       |.:|.|   .
Zfish   120 AS---QRN--GGRVLACGHRYVKKLLGAEEQQRMVGKCYVRGNDLSYDPSDYWQSETYELC---D 176

  Fly   195 VQRQHEDYGLCQAGTSAALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYY----SDHS 255
            .....:..|:|..|.|..:.:.| :..|:||.:||:|::.:.       .||..:.|    :|.|
Zfish   177 FNHDQDLEGMCNMGISGGMTEKD-VYFGTPGSFTWQGTVHMK-------CRDTDSDYAGDANDRS 233

  Fly   256 DLNSPVDKYS-YLGMSVTGG-RFFGHMSYAA--GAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQ 316
            ......||:: |:|.||... :......:..  ||||.|..|.|::.||. |..:.....:.|||
Zfish   234 FGKLGEDKFNIYIGYSVLEDIKLLDRSVFTVVMGAPRDEFKGSVILADKQ-DLILKQLMNITGEQ 297

  Fly   317 FGSSFGYELATADINGDHRPDLIVAAPLYFT--KTEGGAVYVYQNIQDTLPMKYTLKLTGPLESR 379
            .||.||..||..|:|.|...||||.||.||.  |.||||||::.|...:...|.:|.|.|...|.
Zfish   298 IGSYFGSCLAVTDLNNDDWNDLIVGAPFYFDRYKEEGGAVYIFMNENGSFQKKASLVLKGKKGSG 362

  Fly   380 FGLALANIGDLNKDNCEDLAVGAPYEGNGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIR 444
            ||.|:|.:||:|:|..:|:|||||::.:|.|||::||..|:..:|:|.|:...||   |:|  .:
Zfish   363 FGFAIAAVGDVNQDGFQDIAVGAPFQDSGKVYIWMGSKSGITKEPSQVIEGKSLG---PSG--FQ 422

  Fly   445 TFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPNTPGCLDDPA 509
            |||.|:||..|:|.|.|||:::|:.:...| :|.:||:|.:..:      ..::|..  .:....
Zfish   423 TFGYSLSGGMDMDGNDYPDILVGSLDDRIA-LLRSRPVIHLSKN------FTVEPKI--VIPSQC 478

  Fly   510 SNLTCFTFRACCSIEPYDEKN------KELRLAYSVEAETFDHLKKFSRVFFFD-RENKRTNVLS 567
            .| :|...:.|.|   |...|      ||:.:.::::|   |..::.:||.|.| :::..|.:||
Zfish   479 GN-SCIKVKVCFS---YTLSNGNSNFRKEITVKFTIDA---DQNRRGARVRFIDNKQSTFTGLLS 536

  Fly   568 RVVRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPL-ADSALVRLN--PILDQTQAH 629
                   ...:.||.:...:.....|...|:.|.|..||.:... |...|..|:  |:|...|..
Zfish   537 -------FSASSCQELELSVNNPVTDKLQPIVFSLNVSLNQQKAEAQQTLQSLDSFPVLSGQQIL 594

  Fly   630 VD-FEGTFQKDCGDDDLCESNLIIRVE---------PNIT-ESSGNEYTLILDETELEVRINVSN 683
            .| .|..|.|:||||:.|.|||.::..         |:.| |.|.|...|:|       .:.|||
Zfish   595 TDKAEINFHKECGDDNRCSSNLQLKARFADENYNPFPSQTLEFSSNVKKLVL-------MVEVSN 652

  Fly   684 LAD------SAYEAQLFIAHQAGVSYVATKKPTNATCNSYNTTLVACSLGNPMLRDTTTFVTIRF 742
            .||      .|::|.|.|:....:.|...:.|............|.|.||||...:......|.|
Zfish   653 TADENKPAEDAHQATLNISIPYSLKYSGVRPPAGFDMECSADEAVICDLGNPFKSNQKVSFIIIF 717

  Fly   743 QPKGLEPSEKIMLFHIFANTTSKLVGPERPERDL-----RVNVVRRAKLNFRGWAIPEQSFYSGS 802
            :..|:....:.:...:..:|.|:       :.||     .:||.......|....:...:.:||:
Zfish   718 ETSGITLYTEQIQSQLQLSTISE-------QADLFPVLVTLNVKNTILTTFSLEKLIIDTSFSGN 775

  Fly   803 SVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVI--HWPYSLYSDPQSG 865
            .:..|..::.:            ||||.:..:|.:...|........:||  .|||::.:.
Zfish   776 VIGESAMSSTS------------DVGSPLEFVFRVQVLGEPLGDLGTLVIDFDWPYAVANG---- 824

  Fly   866 RPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKS 930
               ::||||.::.....|:..|......||.|||.         ||
Zfish   825 ---KWLLYLTEIVIKGSSESHCVPPGNIVNYLNLT---------LS------------------- 858

  Fly   931 LIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCN 995
                             .:.|:.|:..|...|..           .|:|......::....|||:
Zfish   859 -----------------KEGTKRNKREVDSGFPH-----------AEASVTVLATRKVAHFLDCS 895

  Fly   996 KGATNCVRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMD 1060
            |....|....|.:|||.  ::|:|.|:||:||.||:.:|.:..||.:...||.::........||
Zfish   896 KKTALCQTFSCPLLNMS--TQAEVRVRARVWNGTLLEDYAKALRVEVKGQATLRLLTDKPAIKMD 958

  Fly  1061 HNNIEVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKR----------- 1114
            :...|......|.| .::....:|..|||:..|.|:|||.:::.:|||.|||:|
Zfish   959 NQTREFSVNIDPVL-GEETPYEVPLWIIIVAAVAGILLLGIISLILWKCGFFRRASRREMYEAKS 1022

  Fly  1115 ------IRPTDPTLSGNLEKMNEE 1132
                  |:|::      .|::.||
Zfish  1023 QKAEIKIQPSE------TERLTEE 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	25/68 (37%)
		Int_alpha	317..368	CDD:214549	25/52 (48%)
		Int_alpha	378..428	CDD:214549	24/49 (49%)
		Int_alpha	446..491	CDD:214549	17/44 (39%)
		Integrin_alpha2	480..1006	CDD:462478	119/559 (21%)
itga3b	NP_001177238.1	Int_alpha	38..101	CDD:214549	25/76 (33%)
		Int_alpha	298..346	CDD:214549	25/47 (53%)
		Int_alpha	360..411	CDD:214549	24/50 (48%)
		Integrin_alpha2	457..906	CDD:462478	119/559 (21%)