Protein Alignment mew and itga2b.1

DIOPT Version :9

• Sequence 1: NP_001285196.1
• Gene: mew / 32275
• FlyBaseID: FBgn0004456
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: XP_004918702.1
• Gene: itga2b.1 / 100158580
• XenbaseID: XB-GENE-1009578
• Length: 1034
• Species: Xenopus tropicalis
• Alignment Length: 1215
• Identity: 307/1215 - (25%)
• Similarity: 508/1215 - (41%)
• Gaps: 312/1215 - (25%)

  Fly    24 ILQCVLTCY--NFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNRQPN 86
            :|..||..|  |.||: :.|....|.|.|:||:|:..:         |...::||||..|..:.|
 Frog     6 LLFLVLPTYVQNLNLD-KTPQTLSGPPGSYFGFSLDFY---------KGTSIVVGAPRMQALESN 60

  Fly    87 TTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEI--------KEDQWMGVTVRSNP 143
            .|..|.::.||...:...|..:      |||.   :..|.|.:        |.:||:|..||:
 Frog    61 ITKGGGVFLCPWDPKGSSCTNI------NFDK---TGDGADPLGSYTMKVYKSNQWLGAMVRT-- 114

  Fly   144 LQANGSGGKVIVCA--HRYMYIVRENRYG---QGLCYLLTNDLQFEEVHE--PCKGRPVQRQH-E 200
                 ....::.||  ..:.:|..:...|   .|.||:..|   ..::||  ||:.......: .
 Frog   115 -----WNTAIVACAPLQHWNFIQSDKESGITPTGACYITGN---LHDIHEFAPCRDNKTDSYYAP 171

  Fly   201 DYGLCQAGTSAALLDDDTMVLGSPGPYTWRGSIWVTQVGG------------EYLQRD------- 246
            |...|:.|.||.:..|.|::.|:||.|.::|......|.|            .|..|.
 Frog   172 DNRYCELGFSAEISKDGTLLAGAPGGYFFKGLCATEDVPGILKKPPVAALLKAYPSRQISPNFRF 236

  Fly   247 -KTTYYSDHSDLNSPVDKYSYLGMSVTGGRFFGHMS--YAAGAPRSEGHGQVVIFDKSTDNPIPV 308
             .||:..|           :|.|.||..|.|....:  ...|:|.....|.|.|:  :.|....:
 Frog   237 PPTTFSHD-----------AYKGFSVAYGEFTDDTTPEIVVGSPIYPHMGIVEIY--TNDYQWRI 288

  Fly   309 HSILDGEQFGSSFGYELATADINGDHRPDLIVAAPLYFTKTEG------GAVYVYQNIQDTL--- 364
            ::..: ||..|.||:.:|..|:|.|.:.|::|.|||:..:..|      |.||||  :|.|.
 Frog   289 NTFKE-EQIASYFGHSVAVTDVNNDGKDDVLVGAPLFMERRTGGKLQEVGRVYVY--LQRTYSRF 350

  Fly   365 ----PMKYTLKLTGPLESRFGLALANIGDLNKDNCEDLAVGAPY---EGNGVVYIYLGSSQGLNS 422
                |:....::.|    :||.::|.:||:::|...|:|||||:   .|.|.||||.||:.||:.
 Frog   351 SNDHPVLRGTRVYG----QFGSSIAPLGDIDQDGFNDVAVGAPFGGESGGGCVYIYRGSTAGLSP 411

  Fly   423 KPAQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQT 487
            :|:|.:::     .:|   |...||.::.|.||:|.|.|||:::|||.:....|..|:|::.:|.
 Frog   412 QPSQILES-----PLP---PPTQFGFALRGGTDIDGNGYPDLLVGAFEADKVFIFRAQPVVVLQA 468

  Fly   488 SVQRKELH--NMDPNTPGC-LDDPASNLTCFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLK- 548
            |:   ..|  .::|:...| |....:.::|||...|...   ..:|...:::.|.:.: .|.||
 Frog   469 SL---SFHPEALNPDVKLCKLPQSGAAVSCFTLHVCAQA---SGRNLPKKISLSADLQ-LDRLKS 526

  Fly   549 KFSRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANT--RDIQTPVRFRLKYSLVEPPL 611
            :|:|..||...::.:..:.  :.:|:|....|..:|.|::|.:  :|..:|:...:.:|||:...
 Frog   527 RFARRTFFLDSSQPSKTID--MELHSNSAQLCHNLTAYLRAESEFKDKLSPIAVSVNFSLVKEQS 589

  Fly   612 ADSALVRLNPILDQTQAHVDFEGTFQK-------DCGDDDLCESNLIIRVEPNITESSGNEYTLI 669
            .|:    :.|.|..|        ||.:       |||||::|..:|      ::..:...:..||
 Frog   590 PDT----VQPTLHGT--------TFLQEQTNILLDCGDDNVCIPDL------HLNANWSADPLLI 636

  Fly   670 LDETELEVRINVSNLADSAYEAQLFI-----AHQAGVSYVATKKPTNATCNSYNTTLVACSLGNP 729
            ..:..:.|:.|.:|..:.||||:|.:     ||...|...|.:|...:......:.:|.|.||||
 Frog   637 GIDNLVHVQFNATNFGEGAYEAELHVWLPQGAHYMQVLGEAEEKILCSPKKGNESEIVVCELGNP 701

  Fly   730 M----------------LRDTTTFVTIRFQPK---GLEPSEKIMLFHIFAN--TTSKLVGPERPE 773
            |                |.|:.:.||.:.|.|   .:..:..:.|..:..|  .|.:|.|...|
 Frog   702 MKNGAKIHADLQLSFSNLEDSGSTVTFQMQIKSRNSINSNSPVFLVKMAVNVAATLELRGSSHP- 765

  Fly   774 RDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIF 838
                ..||    |....|...|:|                        ..:.|.|.:|.|::.:.
 Frog   766 ----AEVV----LPLPNWEPREES------------------------RKVQDYGEEVTHVYELH 798

  Fly   839 NEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGS 903
            |.|||:. .||:|:..|.:...|        ||||              .::.|..:.:|..:.|
 Frog   799 NAGPSSV-HVQLVLQSPETYQGD--------YLLY--------------PLSLEVDDKMNCKNQS 840

  Fly   904 RENPAYL------SAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSF 962
            :.||..|      .||..   :.:.|.|..:|..:..:.:       ||..|:.:::.
 Frog   841 KLNPLQLDMFIATEAPVS---YSTGSNHRLDKRDVRKETT-------DDFIDERKNHT------- 888

  Fly   963 LERVTRLERLMYDPESSNAANGKKQDI-----VELDCNKGATNCVRIECDILNMPALSEAQVVVK 1022
                                  ||::.     |.|:|:  :..|..:.|.:.|:.....|.|.:.
 Frog   889 ----------------------KKEETHQKHPVLLNCS--SAPCWEVICSMENLDRGERATVKLH 929

  Fly  1023 ARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYPELRNQQRDTSIPWLI 1087
            :.||..:|:.. |:.:.: :.|..:.|:.   ||..    .|:.||....|   ...:|::.|:.
 Frog   930 SILWIPSLLKR-PQQQFI-LLSQGSFQVT---GVPY----KIQPETLLTGE---AAANTTVLWVS 982

  Fly  1088 -----------IILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPT 1121
                       ||:|.:||||||||..:|:||:|||||.||  ||
 Frog   983 PVGQKEIPLWWIIVGALGGLLLLALFVFVMWKLGFFKRTRP--PT 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	17/62 (27%)
		Int_alpha	317..368	CDD:214549	21/63 (33%)
		Int_alpha	378..428	CDD:214549	24/52 (46%)
		Int_alpha	446..491	CDD:214549	18/44 (41%)
		Integrin_alpha2	479..1006	CDD:285619	122/576 (21%)
itga2b.1	XP_004918702.1	Int_alpha	31..85	CDD:214549	18/68 (26%)
		VCBS	256..319	CDD:404411	17/65 (26%)
		Int_alpha	296..357	CDD:214549	21/62 (34%)
		Int_alpha	363..417	CDD:214549	25/57 (44%)
		Int_alpha	423..>459	CDD:214549	15/35 (43%)
		Integrin_alpha2	460..913	CDD:400650	122/576 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010