DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and itgav

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_012825487.1	Gene:	itgav / 100144691	XenbaseID:	XB-GENE-488969	Length:	1034	Species:	Xenopus tropicalis

Alignment Length:	1181	Identity:	315/1181 - (26%)
Similarity:	523/1181 - (44%)	Gaps:	219/1181 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ILIILQCVLT----CYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQ 81
            ::::||.:|.    |:|.:::.  |.||.|...|:||::|     ...|..:..:.:|||||...
Frog     6 LVLLLQFLLIRLSFCFNLDVDN--PFVKSGSEGSYFGFAV-----DFLNSDSSGSYLLVGAPKAN 63

  Fly    82 NRQPNTTHSGALWRCPMTQRFDDCEQVITD--GRRNFD-SEILSPPGNDEIKEDQWMGVTVRSNP 143
            ..||.....|.:.:|..  :..:|..|:.|  |.||:. :|.:      |.|..||.|.:||:
Frog    64 TSQPGIIEGGDVIKCDW--KNSECRSVVFDPNGNRNYAVNESI------EFKSHQWFGASVRA-- 118

  Fly   144 LQANGSGGKVIVCAHRYMY--IVRENRYGQGLCYLLTNDLQFEEVHEPCKGRPVQRQHEDYGLCQ 206
                 ...|::.||..|.:  .:::.|...|.|||  ||......:.||:.. .:...::.|.||
Frog   119 -----KHNKIMACAPLYHWRTEIKQEREPVGTCYL--NDGITVVEYAPCRSN-AKTDAQEQGFCQ 175

  Fly   207 AGTSAALLDDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYS---DHSDLNSPVD-KY--S 265
            .|.|....:|:.::||.||.:.|:|.:...|| .|.:::.|...||   ::.....|.. .|  |
Frog   176 GGFSIDFTEDNRVLLGGPGSFYWQGQLISDQV-DEIVKKYKPEKYSITYENQLATRPASLSYDDS 239

  Fly   266 YLGMSVTGGRFFGH--MSYAAGAPR-SEGHGQVVIFDKSTDNPIPVHSILD--GEQFGSSFGYEL 325
            |||.|||.|.|.|.  ..:.:|.|| ::..|.|.|:|..|     :.|:.:  |||..:.|||.:
Frog   240 YLGYSVTVGDFSGDNIEDFVSGVPRAAKTLGMVSIYDGKT-----MTSLYNFTGEQMAAYFGYSV 299

  Fly   326 ATADINGDHRPDLIVAAPLYFTK------TEGGAVYVYQNIQDTLPMKYTLKLTG-PLESRFGLA 383
            ||:|||||...||.:.|||:..:      .|.|.|.||.......| ::.:|||| .:.:||...
Frog   300 ATSDINGDGLVDLFIGAPLFMDRGSDGKLQELGQVSVYLQHSTNGP-QHLIKLTGFEIFARFSSC 363

  Fly   384 LANIGDLNKDNCEDLAVGAPYEG---NGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRT 445
            :..:||::.|...|||:.|||.|   .|:||||.|...|::..|:|.::.......:|:     :
Frog   364 IGPLGDIDGDGFNDLAIAAPYGGVNKKGLVYIYNGRPNGMSIVPSQILEGQWASQHMPS-----S 423

  Fly   446 FGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPNTPGCLDDPAS 510
            ||.|:.|.||:|:|.|||:::|||.:..|::..|||:|:: ||:.......::|.:..|.....|
Frog   424 FGYSLKGATDVDENGYPDLLVGAFGADKAILYRARPVITV-TSLLEVNPTILNPESKTCSLPSGS 487

  Fly   511 NLTCFTFRACCSI-----EPYDEKNKELRLAYSVEAETFDHLKK--FSRVFFFDRENKRTNVLSR 568
            .::||..:.|...     .|.|       |.:.|:.....|.:|  ..|..|.   :.|.:..|:
Frog   488 KVSCFYVKFCLKAVGKGRVPQD-------LPFRVDVMLDKHKQKGAIRRALFL---HTRLSSHSK 542

  Fly   569 VVRVHTNGRTECQAVTGYIKANT--RDIQTPVRFRLKYSLVEPPLADSALVRLNPILDQ-TQAHV 630
            .:.:.......|:.:..:::.::  ||..||:...:::.:.....|||:  .|.|||:| |..::
Frog   543 NMTIQNGSGMRCEELQAFLRDDSEFRDKLTPITIFMEFQMDYKSTADSS--GLLPILNQFTPTNI 605

  Fly   631 DFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRINVSNLADSAYEAQLFI 695
            ..:.....|||:|::|:.:|.:.||      |..:...|.|::.|.:.:|..|..:.||||:|.:
Frog   606 TKQAHILLDCGEDNICKPSLKLSVE------SEQKKIFIGDDSPLTLIVNAQNQGEGAYEAELVV 664

  Fly   696 AHQAGVSYVATKKPTNATCNSYN--------TTLVACSLGNPMLRDTTTFVTIRFQPKGLEPSEK 752
            .......::...: .|.|.:..:        |.||.|.|||||...|.....:.|....|...:.
Frog   665 QMPPETDFIGVIR-NNETFSRLSCAFKTENKTHLVVCDLGNPMKAGTQIKAALLFSVHQLTEMDN 728

  Fly   753 IMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIE 817
            .:.|.:...::::.......: .:.:.:...|.:..||.:.|.:.|.       .:||..    :
Frog   729 SVKFDLQIQSSNQYENSSTVQ-SIEIALAVLAAVEVRGVSTPNEVFL-------PIANWE----Q 781

  Fly   818 GHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEV 882
            ...|...:|:|..|.|:|.:.|.|||...|..:.:.|||...:|.        |||:
Frog   782 KMNPETEEDIGPLVQHIFELRNNGPSGFSKAILNLQWPYRYNNDT--------LLYI-------- 830

  Fly   883 SQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDH 947
                  |..|...|:|..|....|      |..:::..|||... |:|.:
Frog   831 ------VKYEIDGPMNCTSDVEIN------PLNVKISASQSNEK-NESRV--------------- 867

  Fly   948 SDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNMP 1012
                ..||.|.||..                 .|.||..|   .|.|  |..:|::|||.:..:.
Frog   868 ----PDNRQRNRRDL-----------------TAMNGHLQ---TLGC--GQADCLKIECHVGRLD 906

  Fly  1013 ALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYPELR-- 1075
            ....|.:.|::|||..|.:....:.....:.|:|      |:.|....:.||.:     |:::
Frog   907 KGKSAILYVRSRLWTLTFLKNGNQNHSYSLKSSA------SFSVLEFPYKNIHI-----PDIQNS 960

  Fly  1076 ----------NQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGNLEKMN 1130
                      ||.....:|..:|||.::.|||||:|:.::::|:|||||:||..       |:..
Frog   961 TVVTTNILWVNQAASLPVPVWVIILAVLSGLLLLSLMVFIMYKLGFFKRVRPPQ-------EEAE 1018

  Fly  1131 EEKPFLAPSKN 1141
            .|:  |.|.:|
Frog  1019 REQ--LQPQEN 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	16/62 (26%)
		Int_alpha	317..368	CDD:214549	21/56 (38%)
		Int_alpha	378..428	CDD:214549	21/52 (40%)
		Int_alpha	446..491	CDD:214549	21/44 (48%)
		Integrin_alpha2	479..1006	CDD:285619	121/544 (22%)
itgav	XP_012825487.1	Int_alpha	36..>80	CDD:214549	14/48 (29%)
		WD40 repeat	177..230	CDD:293791	15/53 (28%)
		Int_alpha	237..>277	CDD:214549	16/39 (41%)
		WD40 repeat	243..287	CDD:293791	15/48 (31%)
		Int_alpha	291..344	CDD:214549	20/52 (38%)
		WD40 repeat	296..352	CDD:293791	21/56 (38%)
		Int_alpha	356..411	CDD:214549	21/54 (39%)
		WD40 repeat	361..412	CDD:293791	19/50 (38%)
		Int_alpha	420..466	CDD:214549	21/51 (41%)
		Integrin_alpha2	457..900	CDD:369878	121/544 (22%)
		Integrin_alpha	1003..1017	CDD:334029	9/20 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11372
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920