Protein Alignment REG and PSME1

DIOPT Version :10

• Sequence 1: NP_572866.1
• Gene: REG / 32274
• FlyBaseID: FBgn0029133
• Length: 245
• Species: Drosophila melanogaster
• Sequence 2: NP_788955.1
• Gene: PSME1 / 5720
• HGNCID: 9568
• Length: 250
• Species: Homo sapiens
• Alignment Length: 212
• Identity: 80/212 - (37%)
• Similarity: 118/212 - (55%)
• Gaps: 1/212 - (0%)

  Fly     8 KVQEYKDSLILKAELLITKGFPENIVRLNELLATPIFNERNFEEVHQDLNIPVLPPLLVKNELED 72
            ||..:::.|..|.|.|:...||:.|..|:..|..|..||.|...:...|:|||..|:..| |.|:
Human    13 KVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAPLDIPVPDPVKEK-EKEE 76

  Fly    73 RDSLPTKRQRVDVIVSGQPVMGLPAGTVPCNKPLCEMIKVVKPIIRKLVEDSNLLKMWISFMIPK 137
            |.....|..:.:.........|.|.|.|.||:.:..:::.:||.|:.::|..||:..|:...||:
Human    77 RKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPR 141

  Fly   138 IEDGNNFGVSIQEDTLAEIQTVESEAAAFFDQISRYFLSRAKVVSKVAKYPHIDDYRRAVVELDE 202
            |||||||||::||.....:.::.::...|..|||:||..|...|:|.||.||:.|||:.|.||||
Human   142 IEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSERGDAVTKAAKQPHVGDYRQLVHELDE 206

  Fly   203 KEYLSLWLVVCEVRNRY 219
            .||..:.|:|.|:||.|
Human   207 AEYRDIRLMVMEIRNAY 223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
REG	NP_572866.1	PA28_alpha	3..63	CDD:460507	19/54 (35%)
		PA28_beta	99..243	CDD:460508	52/121 (43%)
PSME1	NP_788955.1	PA28_alpha	8..68	CDD:460507	19/54 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..102		12/42 (29%)
		PA28_beta	103..224	CDD:460508	52/121 (43%)