DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment REG and psme3

DIOPT Version :9

Sequence 1:	NP_001259502.1	Gene:	REG / 32274	FlyBaseID:	FBgn0029133	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_571451.2	Gene:	psme3 / 30649	ZFINID:	ZDB-GENE-991110-19	Length:	256	Species:	Danio rerio

Alignment Length:	248	Identity:	116/248 - (46%)
Similarity:	177/248 - (71%)	Gaps:	5/248 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NDTVVKVQEYKDSLILKAELLITKGFPENIVRLNELLATPIFNERNFEEVHQDLNIPVLPPLLVK 67
            |:...||..:::.:..:||.|:...||:.::.|::.|..|..|....:|:|.::|:.|..|:|:.
Zfish     9 NEIKTKVDAFRERITSEAEDLVANFFPKKLLELDQFLKDPTINITELQEIHSEINLTVPDPILLT 73

  Fly    68 NELEDRDSLPTKRQRV-----DVIVSGQPVMGLPAGTVPCNKPLCEMIKVVKPIIRKLVEDSNLL 127
            :..:..:....|:::.     |..|.|..|..:|.|.:..|..|.|:|:.|||.||.|:|..|.:
Zfish    74 DIHDGIEGQNAKKRKFEDGAGDDKVGGTKVFVMPGGMMKSNGKLVELIEKVKPEIRTLMEKCNTV 138

  Fly   128 KMWISFMIPKIEDGNNFGVSIQEDTLAEIQTVESEAAAFFDQISRYFLSRAKVVSKVAKYPHIDD 192
            |||:..:||:|||||||||||||:|:||::|||.|||:|.||||||:::|||:|||:|||||::|
Zfish   139 KMWVQLLIPRIEDGNNFGVSIQEETVAELRTVEGEAASFLDQISRYYITRAKLVSKIAKYPHVED 203

  Fly   193 YRRAVVELDEKEYLSLWLVVCEVRNRYSSLHDIVIKNLEKLKKPRSSNTESLY 245
            |||.|.|:|||||:||.::|.|:||:|.:|||:::||:||:|:||||||::||
Zfish   204 YRRTVTEIDEKEYISLKIIVSELRNQYVTLHDMILKNIEKIKRPRSSNTDALY 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
REG	NP_001259502.1	PA28_alpha	5..60	CDD:280421	14/54 (26%)
REG	NP_001259502.1	PA28_beta	102..243	CDD:280422	89/140 (64%)
psme3	NP_571451.2	PA28_alpha	12..68	CDD:280421	15/55 (27%)
psme3	NP_571451.2	PA28_beta	113..253	CDD:280422	88/139 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593975
Domainoid	1	1.000	199	1.000	Domainoid score	I3015
eggNOG	1	0.900	-	-		E1_KOG4470
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2111
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3303
OMA	1	1.010	-	-		QHG56008
OrthoDB	1	1.010	-	-		D1251022at2759
OrthoFinder	1	1.000	-	-		FOG0007262
OrthoInspector	1	1.000	-	-		oto38642
orthoMCL	1	0.900	-	-		OOG6_104507
Panther	1	1.100	-	-	LDO	PTHR10660
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4154
SonicParanoid	1	1.000	-	-		X5366
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800