DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment REG and Y66D12A.9

DIOPT Version :9

Sequence 1:	NP_001259502.1	Gene:	REG / 32274	FlyBaseID:	FBgn0029133	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_499493.1	Gene:	Y66D12A.9 / 176588	WormBaseID:	WBGene00013435	Length:	248	Species:	Caenorhabditis elegans

Alignment Length:	247	Identity:	120/247 - (48%)
Similarity:	176/247 - (71%)	Gaps:	7/247 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPNDTVVKVQEYKDSLILKAELLITKGFPENIVRLNELLATPIFNERNFEEVHQD--LNIPVLPP 63
            ||.:.  ::.|||..|..:||.|:.:.||:.::..:.||.:|..:.....|:..|  ||||: |.
Worm     7 MPENK--ELVEYKQKLFAEAERLVKEEFPKKVIEFDALLKSPKLSYDRLAEILPDKSLNIPI-PD 68

  Fly    64 LLVKNELEDRDSLPTKRQRVDVIVSGQPVMGLPAGTVPCNKPLCEMIKVVKPIIRKLVEDSNLLK 128
            .|  |...|.|....||||||....|.|:....:||||||:.|.:::.:|:|.:|..||..|.:|
Worm    69 AL--NGTTDSDEPAVKRQRVDEKPKGAPIFAFSSGTVPCNENLAQLMDLVRPKLRDAVEQCNNVK 131

  Fly   129 MWISFMIPKIEDGNNFGVSIQEDTLAEIQTVESEAAAFFDQISRYFLSRAKVVSKVAKYPHIDDY 193
            |||:.:||:|||||||||.|||:||:|::.||||||:|.||:||||.:|.|:::|:|||||:|||
Worm   132 MWITLLIPRIEDGNNFGVGIQEETLSEVRNVESEAASFLDQMSRYFTTRGKLITKIAKYPHVDDY 196

  Fly   194 RRAVVELDEKEYLSLWLVVCEVRNRYSSLHDIVIKNLEKLKKPRSSNTESLY 245
            |||::::|||:::::.|||.|:||.:|:|||:::||.||:|.||:||||.||
Worm   197 RRAILDMDEKQFINIRLVVLEMRNHFSTLHDMIMKNYEKIKVPRTSNTEHLY 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
REG	NP_001259502.1	PA28_alpha	5..60	CDD:280421	17/56 (30%)
REG	NP_001259502.1	PA28_beta	102..243	CDD:280422	80/140 (57%)
Y66D12A.9	NP_499493.1	PA28_alpha	11..68	CDD:280421	18/59 (31%)
Y66D12A.9	NP_499493.1	PA28_beta	105..246	CDD:280422	80/140 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165905
Domainoid	1	1.000	194	1.000	Domainoid score	I1855
eggNOG	1	0.900	-	-		E1_KOG4470
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2111
Inparanoid	1	1.050	246	1.000	Inparanoid score	I2042
Isobase	1	0.950	-	0	Normalized mean entropy	S2675
OMA	1	1.010	-	-		QHG56008
OrthoDB	1	1.010	-	-		D1251022at2759
OrthoFinder	1	1.000	-	-		FOG0007262
OrthoInspector	1	1.000	-	-		oto19109
orthoMCL	1	0.900	-	-		OOG6_104507
Panther	1	1.100	-	-	LDO	PTHR10660
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4154
SonicParanoid	1	1.000	-	-		X5366
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790