DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment REG and Aoc3

DIOPT Version :9

Sequence 1:	NP_001259502.1	Gene:	REG / 32274	FlyBaseID:	FBgn0029133	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_033805.1	Gene:	Aoc3 / 11754	MGIID:	1306797	Length:	765	Species:	Mus musculus

Alignment Length:	139	Identity:	29/139 - (20%)
Similarity:	46/139 - (33%)	Gaps:	46/139 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 QRVDVIVSGQPVMGLPAGTVPCNKPLCEMI------KVVKPIIRKLVEDSNLLKMWISFMIPKIE 139
            :||...:|.|..:.|..|..|.:...|.:.      |...|:||.:  |...|..::.:..
Mouse   357 ERVAYEISVQEAIALYGGNSPASMSTCYVDGSFGIGKYSTPLIRGV--DCPYLATYVDWHF---- 415

  Fly   140 DGNNFGVSIQEDTLAEIQTVESEAAAF--FDQ-------------ISRYF------LSRAKVVSK 183
                         |.|.|..::...||  |:|             .|.||      :...:.||.
Mouse   416 -------------LLESQAPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVGTVLVVRSVST 467

  Fly   184 VAKYPHIDD 192
            :..|.:|.|
Mouse   468 LLNYDYIWD 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
REG	NP_001259502.1	PA28_alpha	5..60	CDD:280421
REG	NP_001259502.1	PA28_beta	102..243	CDD:280422	22/118 (19%)
Aoc3	NP_033805.1	TynA	40..716	CDD:226256	29/139 (21%)
		Cu_amine_oxidN2	66..152	CDD:280823
		Cu_amine_oxidN3	169..269	CDD:280824
		Cu_amine_oxid	315..721	CDD:279515	29/139 (21%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P19801	384..394		0/9 (0%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P19801	468..473		1/4 (25%)
		Heparin-binding. /evidence=ECO:0000250	578..585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2675
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950